Psycho-Babble Medication Thread 1107727

Shown: posts 1 to 8 of 8. This is the beginning of the thread.

 

Huperzine A undopaminergic?

Posted by Lamdage22 on January 6, 2020, at 14:09:46

I didn't want to hijack Limone's thread about PTSD.Couple of questions: Is huperzine A cool with Schizophrenia? Can it be anxiogenic? Does it help mood, too? Are there interactions with my meds?

I could use a little mental sharpness for studying.

My cocktail:
800mg Seroquel
25mg Zyprexa
37.5 mg Venlafaxin
75mg Trazodon
225mg Lithium
2000mg Metformin

 

Re: Huperzine A undopaminergic? Lamdage22

Posted by undopaminergic on January 7, 2020, at 3:27:32

In reply to Huperzine A undopaminergic?, posted by Lamdage22 on January 6, 2020, at 14:09:46

> I didn't want to hijack Limone's thread about PTSD.Couple of questions: Is huperzine A cool with Schizophrenia?
>

There's no reason why it shouldn't be. Acetylcholinesterase inhibitors have been investigated as a treatment for cognitive symptoms of schizophrenia, and while it didn't worsen psychosis, it had no notable benefit.

> Can it be anxiogenic?

I think it can, but it wasn't for me.

> Does it help mood, too?

Due to differences between individuals, I believe that is possible. However, I deem it as more likely to worsen mood than improve it. I've seen mention of a "hypercholinergic mouse model of depression". In my experience, it neither improved nor worsened my depression. You just have to try and see.

> Are there interactions with my meds?
>

Not as far as I can tell.

> I could use a little mental sharpness for studying.
>

I remember searching the literature (on PubMed) and I found that dextroamphetamine can be used in schizophrenia to mitigate cognitive and negative symptoms. It can worsen positive symptoms, but this was pretty easily addressed by raising the dose of antipsychotics.

I remember there was one abstract, from France, about a schizophrenic who used street amphetamine on and off, and interestingly, he got psychotic while *off* the amphetamines and killed his wife. The authors of the report suggested that the psychosis might be due neurotoxicity of the amphetamines. Personally, I suggest that amphetamines help you to better think "straight" and gives you self-control that helps impulsiveness. In this way, I believe amphetamines have certain indirect antipsychotic effects.

-undopaminergic

 

Re: Huperzine A undopaminergic?

Posted by sigismund on January 8, 2020, at 22:50:16

In reply to Re: Huperzine A undopaminergic? Lamdage22, posted by undopaminergic on January 7, 2020, at 3:27:32

Any feelings about brahmi / bacopa?

 

Re: Huperzine A undopaminergic? sigismund

Posted by undopaminergic on January 9, 2020, at 2:41:26

In reply to Re: Huperzine A undopaminergic?, posted by sigismund on January 8, 2020, at 22:50:16

> Any feelings about brahmi / bacopa?

I don't think I've heard of brahmi. I think I may have tried bacopa monnieri, but as I don't remember anything about it, there was nothing special about it (ie. it didn't work, as is usual for me).

-undopaminergic

 

Re: Huperzine A undopaminergic?

Posted by greg rizzo on January 9, 2020, at 21:04:46

In reply to Re: Huperzine A undopaminergic? Lamdage22, posted by undopaminergic on January 7, 2020, at 3:27:32

Just some babble from the net
_______________________________________________
Intra-Cellular Therapies announced early Monday morning lumateperone (CAPLYTA) had received approval from the FDA and the company expects the treatment to be available in late Q1 2020.
---------------------------------------------
Mechanism of action
Lumateperone affects multiple systems (serotonergic, dopaminergic and glutamatergic) in the central nervous system. It acts as a antagonist of 5HT2A 0.54nM receptor and modulates D1 4.1nM and D2 3.2nM dopamine receptors where it is a partial agonist at presynaptic and antagonist at postsynaptic receptors. Serotonin transporters at 3.3nM. Through the mTOR pathway, lumateperone aguments both NMDA and AMPA activity. Because of its complex pharmacology, it is not clear which of these activities are primarily responsible for its antidepressive and antipsychotic activities.[14]
----------------------------------------------------------------------------
. With approximately 2.4 million adults with schizophrenia in the United States, the potent serotonin 5-HT2A receptor antagonist, a DPPM acting as a presynaptic partial agonist and postsynaptic antagonist at dopamine D2 receptors, a dopamine D1 receptor-dependent indirect modulator of glutamate, and a serotonin reuptake inhibitor represents a new option to meet the ongoing unmet need for treatments.
-----------------------------------------------------------------
Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the treatment of schizophrenia.1 It has a unique receptor binding profile and differs from other antipsychotics in that it modulates glutamate, serotonin and dopamine, which are all neurotransmitters that contribute to the pathophysiology of schizophrenia.1,5

The data so far indicates that lumateperone can alleviate both positive and negative symptoms of schizophrenia.1 Further, not only is the new antipsychotic selective for dopamine (D2) receptors in the mesolimbic and mesocortical brain regions, but it also has minimal off-target activity.
--------------------
ALSO----Provigil, modafinil,nuvigil (extended release formula (all pretty much the same thing, were developed for narcolepsy (when people can't stay awake).
I have been using it for over a year and I cannot describe how truly amazing it is for depression. I am amazed more psych docs don't recommend it for other than narcolepsy,To save time just google it, but basically increases seratonin and dopamine. It works immediately, is entirely legal (usually need script but I have ways around that). Otherwise very expensive. Take early in am or you'll have trouble sleeping. I have told very few people about this drug--just joined psych-babble.
The source I use is a covert secret--"tell ya but then I'd have to kill ya." Kidding of
course!
On a scale of 1 to 10 for immediate relief of depression and more energy I give it a 10. It's that good.

 

Re: Huperzine A undopaminergic? greg rizzo

Posted by undopaminergic on January 10, 2020, at 2:36:07

In reply to Re: Huperzine A undopaminergic?, posted by greg rizzo on January 9, 2020, at 21:04:46

> --------------------
> ALSO----Provigil, modafinil,nuvigil .. basically increases seratonin and dopamine.
>

Modafinil/armodafinil has no known serotonergic actions.

> It works immediately, is entirely legal (usually need script but I have ways around that).
>

It is actually schedule IV in the US.

-undopaminergic

 

Re: Huperzine A undopaminergic?

Posted by greg rizzo on January 10, 2020, at 8:42:50

In reply to Re: Huperzine A undopaminergic? greg rizzo, posted by undopaminergic on January 10, 2020, at 2:36:07

What's your point. I previously posted all that you wrote.

 

Re: Huperzine A undopaminergic?

Posted by greg rizzo on January 10, 2020, at 8:44:30

In reply to Re: Huperzine A undopaminergic?, posted by greg rizzo on January 10, 2020, at 8:42:50

My bad --i'm mistaken. Sorry.


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