Psycho-Babble Medication Thread 1107687

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Nardil formula

Posted by greg rizzo on January 4, 2020, at 17:11:58

I am in desperate need of help regarding the efficacy of Nardil. I fear for my life because the new nardil pales in comparison to the Parke Davis formula. I am planning to make it my mission in life to re-create the 'old' nardil but I need your help. I have the list of Parke Davis ingredients in the old nardil but I can't find the percentage amounts of each of them. Please help me find the percentages of each of the 15 ingredients. I can then take this to a compounder to make it and help all of us suffering! Thank you in advance!! Greg

 

Re: Nardil formula

Posted by undopaminergic on January 5, 2020, at 8:19:16

In reply to Nardil formula, posted by greg rizzo on January 4, 2020, at 17:11:58

Good luck! Sorry I can't help.

But what about starting with pure phenelzine? It is the main ingredient, and you don't necessarily need anything more than that. Maybe you could make an aqueous solution of it and take it with a pipette/eye-dropper.

-undopaminergic

 

Re: Nardil formula

Posted by undopaminergic on January 6, 2020, at 7:25:43

In reply to Re: Nardil formula, posted by undopaminergic on January 5, 2020, at 8:19:16

> Good luck! Sorry I can't help.
>
> But what about starting with pure phenelzine? It is the main ingredient, and you don't necessarily need anything more than that. Maybe you could make an aqueous solution of it and take it with a pipette/eye-dropper.
>
> -undopaminergic
>

Also, I want to add that it is not only the amounts of specific ingredients, but also the procedures through which the pills are prepared.

Maybe you could ask a compounding pharmacist?

-undopaminergic

 

Re: Nardil formula

Posted by greg rizzo on January 6, 2020, at 16:51:39

In reply to Re: Nardil formula, posted by undopaminergic on January 6, 2020, at 7:25:43

Thanks again for writing. Unfortunately bad news on both fronts. Went to two different compounding companies and neither could find a source to order pure phenelzine sulphate. Therefore no hope there.
However there is some possible good news. Since the new nardil is too quickly metabolized by the liver, we need to find a way to slow that down. According to the compounding pharmacist, one way is to place the nardil tablets into empty cellulose capsues (very cheap).
Another way according to the the literature, is too augment nardil with bioperine (also cheap and available on Amazon). "BioPerine is a natural ingredient, which significantly improves bioavailability and benefits of nutritive compounds" according to sources on the internet.

Giving up is not in my vocabulary and I am exploring other alternatives. Google 'psilocybin for depression.' Also provigil for depression. That's all I'm going to say about this subject for reasons that will become obvious to you after you google it.

 

Re: Nardil formula

Posted by undopaminergic on January 7, 2020, at 3:48:22

In reply to Re: Nardil formula, posted by greg rizzo on January 6, 2020, at 16:51:39

> Thanks again for writing. Unfortunately bad news on both fronts. Went to two different compounding companies and neither could find a source to order pure phenelzine sulphate. Therefore no hope there.
>

I wouldn't say there's no hope. In the worst case, you can order a "custom synthesis" of pretty much any (legal) substance. I believe the compounding pharmacies found no source because they (a) checked only their usual sources, or (b) limited their search to certified pharmaceutical grade phenelzine (sulphate).

Try to do a search on your own. It may help to search for the CAS-number. The CAS# for phenelzine is 51-71-8, and 156-51-4 for the sulphate salt.

> However there is some possible good news. Since the new nardil is too quickly metabolized by the liver, we need to find a way to slow that down.
>

Seems to me you can simply take a higher dose, or take it more frequently.

> According to the compounding pharmacist, one way is to place the nardil tablets into empty cellulose capsues (very cheap).
>

Seems to me that would slow the initial absorption, but not any longer once the capsule has been dissolved.

-undopaminergic

 

Re: Nardil formula

Posted by greg rizzo on January 7, 2020, at 8:49:15

In reply to Re: Nardil formula, posted by undopaminergic on January 7, 2020, at 3:48:22

Tried higher dose of 105 mg from 75mg. I remember the Parke Davis Nardil since I have been on Nardil since 1987.

Let me ask you:has a higher dose and more frequent intervals helped the Nardil become more effective for you

 

Re: Nardil formula

Posted by undopaminergic on January 7, 2020, at 9:00:55

In reply to Re: Nardil formula, posted by greg rizzo on January 7, 2020, at 8:49:15

> Tried higher dose of 105 mg from 75mg. I remember the Parke Davis Nardil since I have been on Nardil since 1987.
>
> Let me ask you:has a higher dose and more frequent intervals helped the Nardil become more effective for you
>

I've never taken Nardil (or generic phenelzine). I haven't tried a classic irreversible unselective MAOI at all.

I would be very interested in trying, in order of preference (a) tranylcypromine (Parnate), (b) isocarboxazid (Marplan), and (c) Nardil. This is because tranylcypromine is the most stimulating, and I do well on stimulants. Nardil is my third choice, because it has GABAergic effects that I think would only produce side-effects for me. It may be the best choice for people with anxiety.

-undopaminergic

 

Re: Nardil formula

Posted by greg rizzo on January 9, 2020, at 16:11:18

In reply to Re: Nardil formula, posted by undopaminergic on January 7, 2020, at 9:00:55

Wrote this request on FDA website under Freedom of Information Act but probably won't do any good.
--------------------------------------
TO: FDA UNDER FREEDOM OF INFORMATION ACT EFFECTIVE DATE JULY 4, 1967
I plan to compound the Parke Davis version of Nardil ( (phenelzine/phenelzine sulphate)
and am requesting the percentage of each excipient (inactive ingredients ONLY).
I DO NOT NEED THE LIST OF THE EXCIPIENTS, ONLY THE PERCENTAGES OF THE INACTIVE INGREDIENTS.
The reason I plan to compound the Park Davis version of nardil is due to the fact that
when Phizer acquired the manufacturing rights (2003) to nardil they changed the list of
excipients formula, and percentages of the excipients (inactive ingredients) as well that were essential,and previously used by Parke Davis. This change resulted in a tragic and dramatic reduction in efficacy. In short, Nardil no longer works even remotely like the Parke Davis formula of old.
--The Nardil using community (only 85,000 nation wide) was in an uproar with many written
and oral complaints to Phizer to no avail. They claimed they changed the formula and
moved the manufacturing to Paraguay only to extend shelf life. BULL! Profitabiliity of
Nardil for Nardil must have been so low that effective in 2019, they no longer
manufacture Nardil at all.
I desperately hope you can help me in my request. Since 'old nardil' was discontined I
and and thousands of others have suffered greatly, and continuely consider seriously
the notion of suicide. The situation is critical.

Thank You!!! GregRizzo


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