Psycho-Babble Medication Thread 1106003

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Metformin could help w/ Schizophrenia/Mania

Posted by PeterMartin on September 2, 2019, at 8:47:15

New study (Sept 2019). It is a rat study and doesn't specifically talk about bipolar, but I've read other recent ones that do. I've been taking Metformin for a yr and a half now to mitigate med wt gain. Hard to say if it's working for that reason but I haven't had any manic episodes. That's good!

Metformin seemingly does a lot of great things. My last pDoc wouldn't subscribe it ("talk to your GP"). Luckily he went back to running studies and my new one had no problem.

https://www.ncbi.nlm.nih.gov/pubmed/31121159

Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.

Abstract
Schizophrenia is known to be a complex and disabling psychiatric disorder. Dopamine receptor antagonists have a significant therapeutic effect in improving the positive symptoms that are associated with the illness. Therefore, dopamine receptor antagonists are commonly used in the treatment of schizophrenia; however, they do not achieve satisfactory results in improving negative symptoms and cognitive impairment. Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents. Metformin's neuroprotective effect has been well documented in several neurological disorders including Alzheimer's disease, Parkinson's disease, strokes, Huntington's disease, and seizures. In the present study, we used a rat model to explore the effect of metformin on schizophrenia-like behaviors induced by MK-801 (dizocilpine), an N-methyl-D-aspartate (NMDA) receptor antagonist. We found that the pre-pulse inhibition (PPI) deficit caused by MK-801 could be alleviated by metformin. The hyperlocomotion in the open field test induced by chronic treatment of MK-801 was reversed by administration of metformin. Metformin has no effect on the baseline level of anxiety in normal naive rats, while metformin could relieve the anxiety-like behaviors in MK-801-treatment rats, though this effect is not reaching a significant level. Additionally, metformin could significantly ameliorate working memory impairments induced by MK-801. Moreover, the increased level of phosphorylation of Akt and GSK3β in the frontal cortex induced by MK-801 was normalized by metformin. In conclusion, our results demonstrate that metformin improved schizophrenia-like symptoms in rats, and is therefore a potential agent for the treatment of schizophrenia.

Brain Res. 2019 Sep 15;1719:30-39. doi: 10.1016/j.brainres.2019.05.023. Epub 2019 May 20.

 

Re: Metformin could help w/ Schizophrenia/Mania

Posted by joe f on September 2, 2019, at 9:10:35

In reply to Metformin could help w/ Schizophrenia/Mania, posted by PeterMartin on September 2, 2019, at 8:47:15

i don't think metformin would do anything for schitzophrenia except maybe control the weight you may put on with a medication for that condition

 

Re: Metformin could help w/ Schizophrenia/Mania

Posted by Lamdage22 on September 2, 2019, at 14:53:27

In reply to Re: Metformin could help w/ Schizophrenia/Mania, posted by joe f on September 2, 2019, at 9:10:35

I have to say that i am doing better since taking metformin. However i have done so many things in attempt to make me better that i am not sure why exactly i am better. It may have to do with metformin, it may not. It certainly doesnt hurt mental health and it is a godsent against AP weight gain.

 

Re: Metformin could help w/ Schizophrenia/Mania

Posted by Lamdage22 on September 2, 2019, at 14:54:04

In reply to Re: Metformin could help w/ Schizophrenia/Mania, posted by Lamdage22 on September 2, 2019, at 14:53:27

"and it is a godsent against AP weight gain."

For me.

 

Re: Metformin could help w/ Schizophrenia/Mania

Posted by linkadge on September 2, 2019, at 17:38:00

In reply to Re: Metformin could help w/ Schizophrenia/Mania, posted by Lamdage22 on September 2, 2019, at 14:54:04

You never know (and perhaps an additional reason to use metformin with AAPs). I believe metformin has a neuroprotective effect and can lower brain inflammation. Same with pioglitazone.

Linkadge


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