Psycho-Babble Medication Thread 602475

Shown: posts 1 to 13 of 13. This is the beginning of the thread.

 

best augmentation agents to use with Parnate

Posted by TylerJ on January 24, 2006, at 19:55:07

I have had treatment resistant depression and social anxiety disorder for about 24 years. I've tried nearly every medication available with little success. In 1997 I was hospitalized and given 24 ECT treatments that barely helped for a short while. I also tried the maoi's and had a good initial response with Parnate. It made me feel better by far than any other drug i had tried. The problem was that it didn't last. The only drug used at that time for augmentation was cytomel, and I was also taking and still am taking 6 mgs. of ativan a day. I felt great for a few days then Parnate would "poop-out" and my pdoc would increase the dose And I would do great for a few days, etc. finally I was up to 140 mgs. of parnate 100 mg. a.m. and 40mg early afternoon. when it quit working my doc took me off it. I also experienced insomnia, and afternoon parnate fatigue. Anyway, it's now 2006 and my same pdoc thinks we should try Parnate again. I agree, but what I have learned is that you must augment parnate with other drugs-mood stabilizers etc. to keep it working. My pdoc agrees with this. So anyone with knowledge of the best augmentation drugs to combine with parnate please help me out. My pdoc says he's open to most things except stimulants. Any suggestions will be appreciated- I'm so tired of feeling lousy!!

sincerely,

TylerJ

 

Re: best augmentation agents to use with Parnate » TylerJ

Posted by shasling on January 24, 2006, at 20:29:01

In reply to best augmentation agents to use with Parnate, posted by TylerJ on January 24, 2006, at 19:55:07

ohmigosh exact same history as me, except I just now started parnate a couple months ago. Its great then leaves, great then leaves. We added Lamictal and I had a very very good response to that. That left as well, but it was a llittle bitty dose, like 12.5 mg. Have to titrate Lamictal very slowly if prone to the dreaded rash, so I am just now up to 40 mg parnate and like 37.5 Lamictal. Might be worth a shot. At 100-200 mg Lamictal has AD properties of its own, so it probably can't hurt anyway. See what your doc thinks, if you all try it, let me know how it goes for you.

Also, Pergolide has been shown to be a good augmentation drug for some people. I'll probably try that next if I can't get a consistent response from the parnate/lamictal.

Best of luck. 24 years is a long time...

Suzie

 

Re: best augmentation agents to use with Parnate

Posted by WeeWilly on January 24, 2006, at 20:33:35

In reply to best augmentation agents to use with Parnate, posted by TylerJ on January 24, 2006, at 19:55:07

> I have had treatment resistant depression and social anxiety disorder for about 24 years. I've tried nearly every medication available with little success. In 1997 I was hospitalized and given 24 ECT treatments that barely helped for a short while. I also tried the maoi's and had a good initial response with Parnate. It made me feel better by far than any other drug i had tried. The problem was that it didn't last. The only drug used at that time for augmentation was cytomel, and I was also taking and still am taking 6 mgs. of ativan a day. I felt great for a few days then Parnate would "poop-out" and my pdoc would increase the dose And I would do great for a few days, etc. finally I was up to 140 mgs. of parnate 100 mg. a.m. and 40mg early afternoon. when it quit working my doc took me off it. I also experienced insomnia, and afternoon parnate fatigue. Anyway, it's now 2006 and my same pdoc thinks we should try Parnate again. I agree, but what I have learned is that you must augment parnate with other drugs-mood stabilizers etc. to keep it working. My pdoc agrees with this. So anyone with knowledge of the best augmentation drugs to combine with parnate please help me out. My pdoc says he's open to most things except stimulants. Any suggestions will be appreciated- I'm so tired of feeling lousy!!
>
> sincerely,
>
> TylerJ

Tyler, you and I are two of a kind. I have struggled like you for many years trying to find a lasting treatment. Parnate works for 3 months for me. Raising the dose up to 100mg's never worked. I am currently on Nardil 75mg's it worked at 60mg's for 3 months then failed. I have decided to switch back to Parnate and augment with Lithuim or Lamictal first. I read where others have added Wellbutrin, Vivactil, stimulants and various other meds. My current Pdoc will not likely prescribe many things like that with the Parnate, but will prescribe Lithium or Lamictal. If those don'nt work I will have to search around for a more helpfull Pdoc. Best wishes.

 

Re: best augmentation agents to use with Parnate

Posted by TylerJ on January 24, 2006, at 20:37:21

In reply to Re: best augmentation agents to use with Parnate » TylerJ, posted by shasling on January 24, 2006, at 20:29:01

Thankyou Suzie, I will definitely tell my doc about Lamictal. I will be starting Parnate on Feb. 10th-I'll let you know how it goes and please stay in touch to let me know how you are doing also.
Best wishes,
TylerJ

 

Re: best augmentation agents to use with Parnate

Posted by TylerJ on January 24, 2006, at 20:42:17

In reply to Re: best augmentation agents to use with Parnate, posted by WeeWilly on January 24, 2006, at 20:33:35

WeeWilly,
Thanks for responding to my thread. I feel for you and wish you the best also. My Doctor says that he will probably add in a thyroid hormone T3. Stay in touch and God bless.
TylerJ

 

Re: best augmentation agents to use with Parnate » TylerJ

Posted by shasling on January 24, 2006, at 20:45:50

In reply to Re: best augmentation agents to use with Parnate, posted by TylerJ on January 24, 2006, at 20:37:21

> Thankyou Suzie, I will definitely tell my doc about Lamictal. I will be starting Parnate on Feb. 10th-I'll let you know how it goes and please stay in touch to let me know how you are doing also.
> Best wishes,
> TylerJ

Okay, Tyler. You, too.

Suzie

 

Re: best augmentation agents to use with Parnate

Posted by naughtypuppy on January 25, 2006, at 14:30:38

In reply to Re: best augmentation agents to use with Parnate » TylerJ, posted by shasling on January 24, 2006, at 20:45:50

Well, It's round number two for Parnate and it doesn't seem to be going too well this time. Last time it calmed me down and made me very motivated. This time around I'm still quite irritable, spaced out and tired. I'm a little reluctant to go with a med like Lamictal, since my previous two attempts with mood stabilizers made me lethargic and stupid. One of Lamictal's more common side effects is rash, and I am batteling one nasty case of hives that the Parnate gave me. Tegrol also gave me a rash. By the way, a real killer combination for any kind of allegic reaction is Doxepin and Ranitidine. It seems that there is a synergistic relationship between H1 and H2 antagonists that makes the combo much more effective than either one alone. Excellent combo for people that are suffering from edema or other allergic reactions to their meds.

 

Re: best augmentation agents to use with Parnate

Posted by TylerJ on January 25, 2006, at 16:12:09

In reply to Re: best augmentation agents to use with Parnate, posted by naughtypuppy on January 25, 2006, at 14:30:38

Sorry it's not going well for you. How much are you taking? Are you augmenting it with any other meds? I've been told that Lithium works very well, and T3 is also supposed to be effective. Have also been told some anti-psychotics, and anti-siezure meds can help i.e., Zyprexa and Geodon . I don't know about you but I'm so tired of this crap that I'm willing to try almost anything. Please let me know how your doing- I wish you all the best.
TylerJ

 

Re: best augmentation agents to use with Parnate » TylerJ

Posted by naughtypuppy on January 25, 2006, at 18:15:14

In reply to Re: best augmentation agents to use with Parnate, posted by TylerJ on January 25, 2006, at 16:12:09

Thanks for your interest. I'm on 40mg per day. Don't think I can go much higher without becoming one giant red ulcer from the allergic reaction. I'm not really taking any augmention meds right now, just doxepin for the hives and oxazapam and trazodone to help me sleep. As far as anticonvulsants go, I've taken valproate and tegrol by themselves and they made me so dozy that I couldn't get off the couch or think clearly. Zyprexa isn't covered by my medical except if you are diagnosed as psycotic and it's so expensive. I know how you feel about trying everything. I've been though SSRI's TCA's MAOI's anti-convulsants and just got crappy side effects from most of them. Makes you want to become a drug addict. At least you'll feel good for a while, which is the best that the anti-depressants have done. The T3 is an interesting idea. In spite of all this nobody has bothered to do a thyroid test or any other tests to eliminate any physical causes. Best wishes to you as well.

"Welcome to my Nightmare"
Alice Cooper

 

Re: best augmentation agents to use with Parnate » naughtypuppy

Posted by shasling on January 25, 2006, at 19:14:43

In reply to Re: best augmentation agents to use with Parnate » TylerJ, posted by naughtypuppy on January 25, 2006, at 18:15:14

Naugtypuppy, you are kidding! Ruling out thyroid dysfunction should have been the very first thing they did. You might want to see a regular doc to see if you can a thyroid panel done - they ought to do that at the very suggestion. A whole metabolic panel would be even better, but that's often harder to talk them into. What is UP with doctors anymore, anyway??....

Suzie

 

Re: best augmentation agents to use with Parnate » shasling

Posted by naughtypuppy on January 25, 2006, at 21:20:01

In reply to Re: best augmentation agents to use with Parnate » naughtypuppy, posted by shasling on January 25, 2006, at 19:14:43

What's down with them is a better question. 5 minutes with my gp telling him I think I have depression and he hands me a prescription and some samples of Paxil. Send the next patient in please! It's almost my tee off time! I think I really should mention to my pdoc that I've never had any physical work done. At least he listens.

 

Re: best augmentation agents to use with Parnate » naughtypuppy

Posted by shasling on January 25, 2006, at 22:13:14

In reply to Re: best augmentation agents to use with Parnate » shasling, posted by naughtypuppy on January 25, 2006, at 21:20:01

I agree. Its a long shot, but what if you didn't have to take these psych meds? You ought to SEE the tests I've made them give me : )

Please think about following through on that.

 

Re: best augmentation agents to use with Parnate

Posted by rose45 on September 1, 2019, at 9:26:04

In reply to best augmentation agents to use with Parnate, posted by TylerJ on January 24, 2006, at 19:55:07

augmenting tith low dose olanzapine worked for me:

https://www.psychiatrictimes.com/bipolar-disorder/augmentation-atypical-antipsychotics


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