Psycho-Babble Medication Thread 577021

Shown: posts 1 to 15 of 15. This is the beginning of the thread.

 

..::: Parnate augmentation? (Nardil other meds)

Posted by Muad' Dib on November 9, 2005, at 5:47:10

Ok I've been taking through august till october - 90mg of "old" Nardil for my social phobia and depression. It has worked WONDERS!!! I mean I never would have believed that a legal med could work in such a way.
Right now I have no more access to Nardil so I started using Parnate for a month. It increases my motivation, I have higher self-esteem but it is NOT Nardil at all! So, I'm thinking of augmenting it with something else. Here is the list of things I've tried and things I would like to try:

- ECA Stack (Ephedrine + Caffeine) = increases sociability and energy
- Klonopin = from 0.5mg-3mg = no effect, at 3mg I get very sleepy
- Alcohol (beers/vodka at reasonable doses) = no effect on sociability (!), without Parnate alcohol makes me *VERY* pro-social and on Nardil it would make me *EXTREMELY PRO-SOCIAL*. But on Parnate it strangely doesn't work.

I haven't tried anything else, but I'm *pretty sure* that following things would work well on sociability with Parnate:

- Xanax or Xanax XR
- Xyrem (GHB)
- amphetamine in low dose

What do you think about augmenting Parnate with:

- Trivastal (piribedil) = potent dopamine agonist D2/D3
- Stablon (tianeptine) = selective serotonin reuptake enhancer - would it be good? or is there a problem with serotonin syndrome?
- Amisulpride = dopamine antagonist D2/D3 and GHB agonist - in the past it worked wonderfully for my social-anxiety, but it pooped out. Do you think it would be wise to use with Parnate?
- any kind of SSRI, especially Prozac ? SSRI alone didn't work at all for me = no good/bad effects.
- Ultram (tramadol) = dangerous or OK at low doses?
- Baclofen = GABA(B) agonist - similar to GHB
- Lyrica (pregabalin)
- Survector (amineptine) = dopamine reuptake inhibitor ? (I guess that would be not so wise because of too much dopamine)
- Adrafinil ?
- Concerta/Ritalin ?
- Gotu Kola? Picamilon? Phenibut?
- "smart drugs" ?


And one last thing - how dangerous is to use Parnate (around 60mg/day) with:

- low dose MDMA
- LSD (200-400 ug)
- psylocybine mushrooms, also low dose

Could I lower my Parnate dose and add DEPRENYL (selegiline) at 5mg/day ? How would such combination work?

I really appreciate your input and take care guys!!!

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by willyee on November 9, 2005, at 13:26:13

In reply to ..::: Parnate augmentation? (Nardil other meds), posted by Muad' Dib on November 9, 2005, at 5:47:10

Wow you post is so similiar to how i feel about parnate,even the augment strategies.Just fyi...


Ive trie


Parnate/Caffiene....Has worked

Parnate/ Gotu Kola..... Has worked

Parnate /Klonopin .... Is not the best,but it has a unique calming affect on the brain that sometimes is needed after a few days.

Parnate/xanax/klonopin.... Usualy much better than anyone benzo alone,the three togther actualy have at times provided social benifit.

Parnate/THC .....After thc is wearing,parnate on occasion blasted a surge of energy along with thc created a wonderful effect.

Parnate/xyrem/ritalin....WHOA,INCREDABLE INTENSE EFFECT,indulgent,total bliss.Parnate and ritalin taken first,then low increments of xyrem are added per 30 min for biuld up,result is total disinhibtition,relaxation,depression oblivated,anxiety gone,warmth,confidence,bliss.

Problem is its too good,and u know its not a feeling u can have constantly.Good news is having parnate and klonopin on hand taken at the end there is actualy no chrash,thank god.

Bad news,when u are no longer able to coninute this combo,parnate and just about everything else becomes instantly INEFFECTIVE,and it can take 2 weeks to achieve statisfactory effect from anything else,its like having a taste of steak and then going back to plain crackers.The two weeks where after where nothing that used to help no longer does squat is just horrid and not worth the bliss of the parnate/ritalin/xyrem combo,least with me.

I freaked when none of my emergency methods pentrated,so i gave up ever doing the awesome threesome again.But i enjoyed a good remission time on it.

Ive also use liquid deprenyl,and a parnate/liquid deprenyl/old anti-pyshcotic combo has worked in the past.The new atypical ones not so,but the older ones did with the parnate/deprenyl.

Your list souns like one id have myself,im very intersted if u would share what u r using now,and ur success with it.Myself........

Parnate/caffiene/ritalin/nuerotion/klonopin/beta blocker.

P.s unless u know something i dont,are u aware the ssri/maoi combo is the one combo u really should not mess with,were talking some horrable reactions there.

 

Re: ..::: Parnate augmentation? (Nardil other meds) willyee

Posted by Phillipa on November 9, 2005, at 20:12:00

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by willyee on November 9, 2005, at 13:26:13

Willyee is that pdoc prescribing all these combose for you? Fondly, phillipa

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by willyee on November 9, 2005, at 21:18:32

In reply to Re: ..::: Parnate augmentation? (Nardil other meds) willyee, posted by Phillipa on November 9, 2005, at 20:12:00

It sounds worse than it is,this is over an extension of 5 years.Also i have brought my mom in to let her know im am watched in the case of emergency.

I also have taken my own steps many many times in obtaining some of the combos.

Also she does so because i go in with papers and data all the time,since i have not called her office in 5 years with any problems she is leaneant.

She has said no on things,many things.She also does not prescribe me many things she does with a smile.

What i do,is if she prescribes me something she had doubts with,ill call her office,leave a message for her on her machine and let her know my status and that it was ok.

Dont get the the wrong idea,she does not hand out stuff to anyone,i am prob a pest of a patient but i try to do the right things,i think calling her is one of them.

I also return medication upon failed trials.So she nows im not sitting with a draw full of them.

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by bigcat on November 9, 2005, at 21:26:47

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by willyee on November 9, 2005, at 21:18:32

Maud,
You should seriously read up on psilocybin with an maoi (google: erowid or the shroomery). apparently, maoi's drastically increase the effects of psilocybin. this could be extremely dangerous, and I highly advise you to resist this temptation. i've heard that some mushroom enthusiasts eat syrian rue seeds before tripping to jolt up the experience. but this is like adding coffee (a stimulant) as opposed to adding a mega dose of ampthetamine, and you could wind up in SERIOUS trouble.

 

Re: ..::: Parnate augmentation? (Nardil other meds) Muad' Dib

Posted by Declan on November 11, 2005, at 13:11:25

In reply to ..::: Parnate augmentation? (Nardil other meds), posted by Muad' Dib on November 9, 2005, at 5:47:10

Hi, you could take Parnate and deprenyl together IMO.

It wouldn't be much of a trip on Parnate and LSD or MDMA (for me). Even if the combination caused you no problems, you'd still be so watchful of your pulse, blood pressure and watchful for signs of seratonin syndrome. It'd be a nightmare to deal with if anything went wrong. (Where is my mind now that I need it? Is it time to take the nefedipine? Isn't cardiac failure a side effect of that. Where's my medical book?)

OTOH what do I know? I did take speed (not much) and Parnate together. You wouldn't want to take too much (BP went up, and I was only on Parnate 10mg/d). On Parnate my BP seemed more unstable generally.

Declan

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by OhYouKnow on May 14, 2018, at 16:32:28

In reply to ..::: Parnate augmentation? (Nardil other meds), posted by Muad' Dib on November 9, 2005, at 5:47:10

Not convinced that shrooms and MAOIs automatically cause a bad reaction. Esp. after one poster said to read Erowid and Shroomery, people are combining them in various ways.

However, I use 6mg Emsam daily. It's prescribed to me by a doctor for medical purposes (abates my CFS/FM symptoms 85%).

I typically am a lightweight and with other medical issues, I'm not very experimental. But I want to microdose mushrooms (no idea/preference what variety) for psychological "clarity" on some personal matters and issues. I'm looking for info about safety concerns of microdosing psylocibin while taking 6mg transdermal Emsam.

What do I need to look out for? Do I need a washout period?

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by Lamdage22 on May 23, 2018, at 13:24:01

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by OhYouKnow on May 14, 2018, at 16:32:28

I would advise against doing that. It may shoot you into psychosis, possibly irreversible schizophrenia.

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by rose45 on September 1, 2019, at 9:24:16

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by willyee on November 9, 2005, at 13:26:13

augmenting with low dose olanzapine - worked for me
https://www.psychiatrictimes.com/bipolar-disorder/augmentation-atypical-antipsychotics

 

Re: ..::: Parnate augmentation? (Nardil other meds) rose45

Posted by porkpiehat on November 19, 2019, at 7:58:43

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by rose45 on September 1, 2019, at 9:24:16

> augmenting with low dose olanzapine - worked for me
> https://www.psychiatrictimes.com/bipolar-disorder/augmentation-atypical-antipsychotics
>
> ROSE what were you effects were you seeking augment with the olanzapine: mood boost or stabilization? Also wondering how long it took for you.

thanks
>
>

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by rose45 on December 21, 2019, at 4:32:16

In reply to Re: ..::: Parnate augmentation? (Nardil other meds) rose45, posted by porkpiehat on November 19, 2019, at 7:58:43

> > augmenting with low dose olanzapine - worked for me
> > https://www.psychiatrictimes.com/bipolar-disorder/augmentation-atypical-antipsychotics
> >
> > ROSE what were you effects were you seeking augment with the olanzapine: mood boost or stabilization? Also wondering how long it took for you.
>
> thanks
> >
> >
> Sorry for the delay in replying porkpie hat. Ive only just seen your post. I had decreased the parnate, because I was feeling better and thought id be ok on a lower dose - and it just stopped working altogether even when I then increased it back up to 40mg per day. However, after a couple of weeks on olanzapine, it started working again! A total miracle ! I wish I could understand the chemistry of it, but the main thing is that parnate is now working even better than before (I was previously on 30mg).
>

 

Re: ..::: Parnate augmentation? (Nardil other meds) rose45

Posted by undopaminergic on December 21, 2019, at 9:12:51

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by rose45 on December 21, 2019, at 4:32:16

> > > augmenting with low dose olanzapine - worked for me
...
> > > ROSE what were you effects were you seeking augment with the olanzapine: mood boost or stabilization? Also wondering how long it took for you.

> Sorry for the delay in replying porkpie hat. Ive only just seen your post. I had decreased the parnate, because I was feeling better and thought id be ok on a lower dose - and it just stopped working altogether even when I then increased it back up to 40mg per day. However, after a couple of weeks on olanzapine, it started working again! A total miracle ! I wish I could understand the chemistry of it, but the main thing is that parnate is now working even better than before (I was previously on 30mg).
>
>

This goes to show, that there is a lot we still have to figure out about neurobiology. To me it is counter-intuitive that olanzapine would help for depression. Then again, olanzapine is more than just a dopamine-antagonist, so there are several mechanisms that could be at play.

-undopaminergic

 

Re: ..::: Parnate augmentation? (Nardil other meds) Muad' Dib

Posted by undopaminergic on December 21, 2019, at 9:51:56

In reply to ..::: Parnate augmentation? (Nardil other meds), posted by Muad' Dib on November 9, 2005, at 5:47:10

> Ok I've been taking through august till october - 90mg of "old" Nardil for my social phobia and depression. It has worked WONDERS!!! I mean I never would have believed that a legal med could work in such a way.
> Right now I have no more access to Nardil so I started using Parnate for a month. It increases my motivation, I have higher self-esteem but it is NOT Nardil at all!
>

Nardil (phenelzine) has a GABAergic effect that other MAOIs do not share. That may explain the difference, especially regarding social phobia.

> So, I'm thinking of augmenting it with something else. Here is the list of things I've tried and things I would like to try:
>
> - ECA Stack (Ephedrine + Caffeine) = increases sociability and energy
>

Ephedrine releases noradrenaline and with a MAOI, it could induce severe hypertension. As always, it is the dose that makes the poison, so if you start low and follow up on your blood pressure, you should be safe. If you have already tried this safely, it would suggest amphetamine can also be used safely.

> - Klonopin = from 0.5mg-3mg = no effect, at 3mg I get very sleepy
>

This is, along with other benzodiazepines, the most intuitive thing to try. Too bad that it didn't work.

> - Alcohol (beers/vodka at reasonable doses) = no effect on sociability (!), without Parnate alcohol makes me *VERY* pro-social and on Nardil it would make me *EXTREMELY PRO-SOCIAL*. But on Parnate it strangely doesn't work.
>

Yes, that is strange. As if the Parnate somehow keeps you sober.

> I haven't tried anything else, but I'm *pretty sure* that following things would work well on sociability with Parnate:
>
> - Xanax or Xanax XR

Yes, like I said, a benzo is an intuitive addition. And it's safe. It's worth trying.

> - Xyrem (GHB)

If you can stay awake, yes, it may work for sociability. It has been called the liquid ecstasy.

> - amphetamine in low dose
>

With caution, this can be a powerful augmentation.

> What do you think about augmenting Parnate with:
>
> - Trivastal (piribedil) = potent dopamine agonist D2/D3
>

Or pramipexole or ropinirole.

> - Stablon (tianeptine) = selective serotonin reuptake enhancer - would it be good? or is there a problem with serotonin syndrome?
>

There's no obvious reason why this wouldn't be safe. It does the opposite of SSRIs.

> - Amisulpride = dopamine antagonist D2/D3 and GHB agonist - in the past it worked wonderfully for my social-anxiety, but it pooped out. Do you think it would be wise to use with Parnate?
>

Excellent idea in my mind. Sulpiride is an alternative. So is flupenthixol.

> - any kind of SSRI, especially Prozac ? SSRI alone didn't work at all for me = no good/bad effects.
>

This is very dangerous. Better experiment with tryptophan first, and then 5-hydroxytryptophan (5-HTP). Be careful.

> - Ultram (tramadol) = dangerous or OK at low doses?
>

At low enough doses yes, but at normal doses it could induce serotonin syndrome.

> - Baclofen = GABA(B) agonist - similar to GHB
> - Lyrica (pregabalin)

Both of these should be safe.

> - Survector (amineptine) = dopamine reuptake inhibitor ? (I guess that would be not so wise because of too much dopamine)
>

Yes, right. You could possibly get a psychotic or manic reaction. This substance is also hard to get your hands on.

> - Adrafinil ?

Safe enough, but why not modafinil instead?

> - Concerta/Ritalin ?

Should be safe, but caution is warranted. There is some evidence that methylphenidate can elevate adrenaline.

> - Gotu Kola? Picamilon? Phenibut?
> - "smart drugs" ?

Most of them should be safe, but you need to research specific options more carefully.

> And one last thing - how dangerous is to use Parnate (around 60mg/day) with:
>
> - low dose MDMA

Extremely dangerous.

> - LSD (200-400 ug)
> - psylocybine mushrooms, also low dose

These should be safe, but the tranylcypromine (Parnate) (and other drugs taken at the same time) could alter your "trip", possibly in a bad way.

> Could I lower my Parnate dose and add DEPRENYL (selegiline) at 5mg/day ? How would such combination work?
>

Adding selegiline should be equivalent to low doses of amphetamines. Otherwise, adding a MAO-B inhibitor to a potent unselective MAOI would be pointless. Note that the amphetamines you get from selegiline are the l-isomers, and there is a reason why the d-isomers (dextro-) are usually preferred in most amphetamine preparations -- only Adderall contains any l-amphetamine at all.

> I really appreciate your input and take care guys!!!
>

I hope you're still around to read this!

-undopaminergic

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by greg rizzo on January 9, 2020, at 20:30:58

In reply to Re: ..::: Parnate augmentation? (Nardil other meds) Muad' Dib, posted by undopaminergic on December 21, 2019, at 9:51:56

UNDOPAMINERGIC---SO HAPPY nARDIL IS WORKING FOR YOU1 fACT IS HOWEVER, "OLD NARDIL" WAS DISCONTINUED IN 2003 WHEN pHIZER BOUGHT THE MANUFACTURING RIGHTS FROM PARKE DAVIS AND ALSO CHANGED THE FORMULA ADVERSLY IN MOST PEOPLE'S OPINION.
Been on nardil since 1988 so made it my mission to learn as much as I can about it's efficacy.

 

Re: ..::: Parnate augmentation? (Nardil other meds)

Posted by undopaminergic on January 10, 2020, at 3:48:28

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by greg rizzo on January 9, 2020, at 20:30:58

> UNDOPAMINERGIC---SO HAPPY nARDIL IS WORKING FOR YOU ...
>

I'm sorry, but I never tried Nardil. I would like to.

-undopaminergic


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.