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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by tensor on December 20, 2006, at 9:26:59
I've been on Remeron 15mg + Zoloft 50mg + Lamictal 100mg for recurring TR depression(2mg clon for anxiety). The Lamictal trial ends today, I have been up to 200mg but no success. Now starting Zyban(Wellbutrin) 150mg + 50mg Zoloft. Zyban is only indicated for nicotine addiction here, so maybe I'm the first in the nordic to use it for depression. My pdoc was enthusiastic about trying it because he had never heard of it before I overwhelmed him with articles and docs about the med.
I hope it will work. A bit disappointing Lamictal didn't for work 'cause it could been good for preventing relapses. I've read that it's probably more effective for bipolar depression than for unipolar./Mattias
Posted by tensor on December 20, 2006, at 10:51:22
In reply to New treatment regime today, posted by tensor on December 20, 2006, at 9:26:59
Just noticed that bupropion is an inhibitor of CYP-2D6 and sertraline is a substrate for the same enzyme. I can't find anything in my literature that mentions any interaction between them neither do the online drug interaction checkers. Any ideas about this?
/Mattias
Posted by Phillipa on December 20, 2006, at 11:45:01
In reply to Re: New treatment regime today, posted by tensor on December 20, 2006, at 10:51:22
Good luck Tensor. My thoughts are with you. Love Phillipa
Posted by stargazer on December 20, 2006, at 23:02:18
In reply to New treatment regime today, posted by tensor on December 20, 2006, at 9:26:59
I liked Wellbutrin and it helped me when I took it with Celexa and Adderall. It was used for depression here in the States long before used for smoking cessation.
I think it could work very well for you with the combination you are on.
I too hated Lamictal. I didn't even know it until I started to trip and fall down, not once but multiple times and neither my pdoc or myself thought of Lamictal causing that. It wasn't until I went to a neurologist who said that could be causing my unsteadiness. Also it made my mind turn to mush, not ability to think beyond the surface level.
Good luck with Buproprion, aka Wellbutrin
Stargazer
Posted by rosa63 on December 21, 2006, at 4:53:09
In reply to New treatment regime today, posted by tensor on December 20, 2006, at 9:26:59
> Zyban(Wellbutrin) 150mg + 50mg Zoloft.
I know LOTS of people who have had tremendous success with Welbutrin - myself included. The combo is quite popular(aka "Welloft"). Welbutrin should help improve your motivation and energy and you will DEFINITELY lose the weight you may have gained with Remeron. Good luck!!!!
Posted by tensor on December 21, 2006, at 10:27:48
In reply to Re: New treatment regime today » tensor, posted by Phillipa on December 20, 2006, at 11:45:01
Posted by tensor on December 21, 2006, at 10:51:34
In reply to Re: New treatment regime today/Good luck, posted by stargazer on December 20, 2006, at 23:02:18
>I too hated Lamictal. I didn't even know it until I started to trip and fall down
I have heard others say the same about Lamictal, strange s/e.
>I know LOTS of people who have had tremendous success with Welbutrin - myself included. The combo is quite popular(aka "Welloft"). Welbutrin should help improve your motivation and energy and you will DEFINITELY lose the weight you may have gained with Remeron. Good luck!!!!
Thanks, I have no experience from this med. This much I know though, it IS stimulating. I used to smoke when I was younger and currently this med is giving me the same feeling as the first cigarette did. I swear, if I took a cigarette now I would puke. Will this nauseous feeling pass? I have only taken two doses but it would be nice to know what to expect, I guess the nausea/insomnia is a side effect from increased dopamine. And yeah, some weight loss is welcomed after long periods of Remeron and nortriptyline.
I'm familiar with term "Welloft" :-), I hope it will work well for me.>Good luck with Buproprion, aka Wellbutrin
StargazerThank you. Are you guys still on Wellbutrin or has it pooped-out or discontinued for some other reasons?
/Mattias
Posted by rosa63 on December 21, 2006, at 12:50:44
In reply to Stimulating, indeed., posted by tensor on December 21, 2006, at 10:51:34
> Thanks, I have no experience from this med. This much I know though, it IS stimulating. I used to smoke when I was younger and currently this med is giving me the same feeling as the first cigarette did. I swear, if I took a cigarette now I would puke. Will this nauseous feeling pass? I have only taken two doses but it would be nice to know what to expect, I guess the nausea/insomnia is a side effect from increased dopamine. And yeah, some weight loss is welcomed after long periods of Remeron and nortriptyline.
> I'm familiar with term "Welloft" :-), I hope it will work well for me.
>
> >Good luck with Buproprion, aka Wellbutrin
> Stargazer
>
> Thank you. Are you guys still on Wellbutrin or has it pooped-out or discontinued for some other reasons?I recently started back (a month ago) on Wellbutrin after being off of it for several years. I take it with 60 mg of Cymbalta. When I first started taking it again, I was extremely agitated and edgy, but the agitation is fading and I have lots of wanted energy and the motivation is coming slowly. Hopefully you will not experience the agitation. I think that the Zoloft would complement Wellbutrin very well.
Oh, and for sleep I take 1mg of Klonopin and 50 mg Trazodone (and have for years). On Wellbutrin, I am only sleeping 5-7 hours a night. Keep us posted on your results!!!
Posted by tensor on December 21, 2006, at 15:22:03
In reply to Re: Stimulating, indeed. » tensor, posted by rosa63 on December 21, 2006, at 12:50:44
Hi Rosa,
I take regularly clonazepam 2mg daily for anxiety. I also have zopiclone for insomnia, usually works well, but it happens often that I wake up about 3h after intake, and it's often hard to fall asleep again. Could do better with a hypnotic with slightly longer halflife.
Energy and motivation is exactly what I'm lacking./Mattias
Posted by rosa63 on December 21, 2006, at 15:49:05
In reply to Re: Stimulating, indeed. » rosa63, posted by tensor on December 21, 2006, at 15:22:03
> Hi Rosa,
>
> I take regularly clonazepam 2mg daily for anxiety.Does Klonopin make you sleepy when you take it during the day? I wish I could take it during the day, but it always makes me sleepy.
Sleep is difficult on Wellbutrin at first, but for me, insomnia does go away after the first month or two. Have you tried Trazodone at night for sleep?
Posted by tensor on December 21, 2006, at 16:02:25
In reply to Re: Stimulating, indeed. » tensor, posted by rosa63 on December 21, 2006, at 15:49:05
>Does Klonopin make you sleepy when you take it during the day?
No, I take it in the morning and it has never been a problem for me. I have been taken it for years though.
>Have you tried Trazodone at night for sleep?
No I haven't actually, does it work well? Any hangover?
/Mattias
Posted by rosa63 on December 21, 2006, at 16:16:48
In reply to Re: Stimulating, indeed. » rosa63, posted by tensor on December 21, 2006, at 16:02:25
> No I haven't actually, does it work well? Any hangover?It is very effective for sleep and anxiety. For me, I am groggy the next day if I take more than 50 mg. Lots of people can take 150-250 mg a night with great success.
See how people rate it:
http://www.askapatient.com/viewrating.asp?drug=18207&name=DESYREL
Posted by tensor on December 21, 2006, at 16:29:45
In reply to Re: Stimulating, indeed., posted by rosa63 on December 21, 2006, at 16:16:48
Thanks, I will see how the insomnia develops during the first two months.
/Mattias
Posted by jimmygold70 on December 22, 2006, at 4:44:19
In reply to New treatment regime today, posted by tensor on December 20, 2006, at 9:26:59
Why haven't you tried taking the Zoloft dose up (100-150 MG is a good range)?
Assuming you did cosider that. Adding Zyban is a great idea. The combination is nicknamed "Well-Loft" (Wellbutrin + Zoloft). It's very popular. Watch for agaitation and irritability on this combination, as it may activate hidden Bipolar II.Good luck and give feedback,
Jimmy
> I've been on Remeron 15mg + Zoloft 50mg + Lamictal 100mg for recurring TR depression(2mg clon for anxiety). The Lamictal trial ends today, I have been up to 200mg but no success. Now starting Zyban(Wellbutrin) 150mg + 50mg Zoloft. Zyban is only indicated for nicotine addiction here, so maybe I'm the first in the nordic to use it for depression. My pdoc was enthusiastic about trying it because he had never heard of it before I overwhelmed him with articles and docs about the med.
> I hope it will work. A bit disappointing Lamictal didn't for work 'cause it could been good for preventing relapses. I've read that it's probably more effective for bipolar depression than for unipolar.
>
> /Mattias
Posted by tensor on December 22, 2006, at 7:05:49
In reply to Re: New treatment regime today » tensor, posted by jimmygold70 on December 22, 2006, at 4:44:19
>Why haven't you tried taking the Zoloft dose up (100-150 MG is a good range)?
We wanted to see if Lamictal would contribute with an antidepressant effect itself. A response from Zoloft would have masked that.
>Good luck and give feedback
Thanks, I will keep you posted.
/Mattias
Posted by Oppycat on December 26, 2006, at 9:28:06
In reply to Re: Stimulating, indeed. » rosa63, posted by tensor on December 21, 2006, at 16:02:25
> >Does Klonopin make you sleepy when you take it during the day?
>
> No, I take it in the morning and it has never been a problem for me. I have been taken it for years though.
>
> >Have you tried Trazodone at night for sleep?
>
> No I haven't actually, does it work well? Any hangover?
>
> /Mattias
My girlfriend has taken Wellbutrin and 100 mg of trazodone for sleep for years. She sleeps fine. I also took 100-150mg Trazodone with Parnate for years with success.Michael
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