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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by rod on November 24, 2002, at 5:50:45
http://bipolar.about.com/library/weekly/aa-ssridiscon02.htm
...SSRIs, when discontinued or when the dosage is lowered, produce an "anticholinergic rebound," which is an interruption in production of the key neurotransmitter acetylcholine...
hmm, I wonder if an ACE Inhibitor (Acetylcholine Esterase Inhibitor) would help.
Posted by IsoM on November 24, 2002, at 12:47:30
In reply to SSRI Discontinuation Syndrome, posted by rod on November 24, 2002, at 5:50:45
I keep mentioning this but no one's ever commented on it yet.
I found that when I took adrafinil (Olmifon), it completely stopped the discontinuation symptoms I had. I now take modafinil (Provigil -USA or Alertec -Canada) instead & think it may have definite benefits in that regard. When I broached the idea to my pharmacist, he was quite interested. He felt I should write the pharmaceutical company & tell them my results. I really wish I would hear more about this possibility as modafinil does activate different areas of the brain & affects different neurotranmitters than SSRIs.
Posted by rod on November 28, 2002, at 5:48:11
In reply to Re: SSRI Discontinuation Syndrome » rod, posted by IsoM on November 24, 2002, at 12:47:30
> I keep mentioning this but no one's ever commented on it yet.
>
> I found that when I took adrafinil (Olmifon), it completely stopped the discontinuation symptoms I had. I now take modafinil (Provigil -USA or Alertec -Canada) instead & think it may have definite benefits in that regard. When I broached the idea to my pharmacist, he was quite interested. He felt I should write the pharmaceutical company & tell them my results. I really wish I would hear more about this possibility as modafinil does activate different areas of the brain & affects different neurotranmitters than SSRIs.I recently lowered my dosage of Effexor XR (although it is not an SSRI), and it is worsening many symptoms, which I _suspect_ result in disturbed acetylcholin system.
But, Adrafinil does not help (I took a single dose of 300mg). I also have to say that I never got a usefull effect from adrafinil in previous atteppts, tryouts.But interesting anyway to hear that you found this.
Posted by IsoM on November 28, 2002, at 11:31:05
In reply to Re: SSRI Discontinuation Syndrome, posted by rod on November 28, 2002, at 5:48:11
Thanks for reply, Rod. I can't speak about single doses of adrafinil. What happened was that I begin taking adrafinil for narcolepsy on my own (before my doctor prescribed modafinil, Provigil). I was taking adrafinil for a couple of months at the time I ran out of my Paxil. I was also on the max dose of adrafinil.
This is the end of the thread.
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