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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by rjlockhart on February 25, 2007, at 14:08:31
Well where talking about alot of smoking.
I was just wondering if chain smoking inhibits MAO-B. At high levels.
?
Posted by linkadge on February 25, 2007, at 14:08:31
In reply to Do ciggerettes act as a MAOI, posted by rjlockhart on February 23, 2007, at 14:23:02
Yes.
Linkadge
Posted by rjlockhart on February 25, 2007, at 14:08:31
In reply to Do ciggerettes act as a MAOI, posted by rjlockhart on February 23, 2007, at 14:23:02
How does it happen, when a person chain smokes does it really inhibit MAO-B, i have realized well i have smoked, when in high stress, increased smoking for me, but i realize sometimes at high smoking rates im in a altered mind set.
Can you explain?
Posted by linkadge on February 25, 2007, at 14:09:42
In reply to Re: tell me a little more, thanks, posted by rjlockhart on February 23, 2007, at 20:28:52
Cigarette smoke contains substances which are MAO inhibitors.
The substances appear to inhibit both MAO-A and MAO-B.
It is a little less powerfull than prescription MAO inhibitors, but the effect is still significant. Ie. Moderate smoker would inihibit ~50% of brain MAOa/b.
Here is a picture showing how smoking reduces MAO-A levels. (This would be similar for MAO-B levels)
It compares it to tranylcypromine (parnate) treatment,http://www.pnas.org/cgi/content/full/93/24/14065/F2
Linkadge
Posted by Ken Blades on February 25, 2007, at 14:09:43
In reply to Re: tell me a little more, thanks, posted by linkadge on February 24, 2007, at 8:46:39
After I quit smoking once and for all, my
depression deepened...it was the one aspect
of quitting that kept me on the verge of
re-starting. My being on Parnate has not
lifted my depression as much as it has
helped my social anxiety, but I will say
that it[the depression]is now at a level
comparable to the time when I was a 2 pack
a-day smoker.
Posted by linkadge on February 25, 2007, at 14:09:43
In reply to Re: tell me a little more, thanks » linkadge, posted by Ken Blades on February 25, 2007, at 0:37:17
Yeah, there is more to cigarettes that just MAO inhibition. The nicotine in cigarettes also has a strong effect. In some instances, nicotine alone has antidepressant properties. The MAO inhibition magnifies the pleasurable effects of nicotine.
Linkadge
Posted by Ken Blades on February 25, 2007, at 14:09:43
In reply to Re: tell me a little more, thanks, posted by linkadge on February 25, 2007, at 10:32:42
Oh for sure, nicotine has stimulant effects
on the old body chemistry beyond the MAO
inhibition. I definitely missed the effects
and I can't count the number of times I
either thought about smoking, even buying
cigarettes and finally giving them away.It was only learning that my grandfather
died of lung cancer after a lifetime of
heavy smoking could I remain an ex-smoker.
This is the end of the thread.
Psycho-Babble Substance Use | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
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