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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 74 to 98 of 98. Go back in thread:
Posted by Brainbeard on June 2, 2010, at 2:47:03
In reply to Re: Brainbeard, babblemail me!, posted by Brainbeard on May 29, 2010, at 15:10:44
Posted by CrAzYmEd on June 2, 2010, at 8:58:02
In reply to I have ordered lisuride (nm), posted by Brainbeard on June 2, 2010, at 2:47:03
Nice man! Keep us updated!
What other meds are on again? (that used to be in your sig i think but i accidenly turned that off).
Posted by Brainbeard on June 2, 2010, at 13:10:17
In reply to Re: I have ordered lisuride, posted by CrAzYmEd on June 2, 2010, at 8:58:02
> Nice man! Keep us updated!
> What other meds are on again? (that used to be in your sig i think but i accidenly turned that off).Erm, 125mg of sertraline (obn Zoloft), 20mg of pipamperone (Dipiperone), one quarter of a Deanxit pill (10mg melitracene + 0.5mg flupentixol), 0.3mg melatonin. Occasionally: methylphenidate (obn Ritalin) 10mg, 5-10mg oxazepam, 2.5-5mg diazepam.
Posted by g_g_g_unit on June 5, 2010, at 20:49:38
In reply to My Bloody Regimen, posted by Brainbeard on June 2, 2010, at 13:10:17
> Erm, 125mg of sertraline (obn Zoloft)this is the only SSRI i'm still interested in trying. are you finding that it has a more favourable side-effect profile to the others as far as cognition goes? i've read it's the least likely to have an impact on memory, etc.
Posted by SLS on June 6, 2010, at 0:21:24
In reply to Re: My Bloody Regimen » Brainbeard, posted by g_g_g_unit on June 5, 2010, at 20:49:38
>
> > Erm, 125mg of sertraline (obn Zoloft)
>
> this is the only SSRI i'm still interested in trying. are you finding that it has a more favourable side-effect profile to the others as far as cognition goes? i've read it's the least likely to have an impact on memory, etc.
Zoloft is the SSRI that produced the most "brain fog" for me. I was taking 200mg.
- Scott
Posted by g_g_g_unit on June 6, 2010, at 0:23:25
In reply to Re: My Bloody Regimen » g_g_g_unit, posted by SLS on June 6, 2010, at 0:21:24
>
>
>
> Zoloft is the SSRI that produced the most "brain fog" for me. I was taking 200mg.
>
>
> - Scottoh strange .. did the effect vary at different doses? which produced the least?
Posted by Conundrum on June 6, 2010, at 1:18:10
In reply to Re: My Bloody Regimen » g_g_g_unit, posted by SLS on June 6, 2010, at 0:21:24
Isn't 200mg the highest dose?
Posted by Brainbeard on June 6, 2010, at 1:19:56
In reply to Re: My Bloody Regimen » Brainbeard, posted by g_g_g_unit on June 5, 2010, at 20:49:38
>
> > Erm, 125mg of sertraline (obn Zoloft)
>
> this is the only SSRI i'm still interested in trying. are you finding that it has a more favourable side-effect profile to the others as far as cognition goes? i've read it's the least likely to have an impact on memory, etc.
>
>Sertraline doesn't produce any cognitive debilitation for me. In a study with elderly folks, it actually improved cognition. The SSRI's usually don't impair cognition much, if at all. When I was starting up fluvoxamine (Luvox), it made me terribly slow at work, but that disappeared once my brain got used to the drug.
Posted by Conundrum on June 6, 2010, at 1:22:11
In reply to Re: My Bloody Regimen, posted by g_g_g_unit on June 6, 2010, at 0:23:25
Other options are effexor and nefazodone for OCD. Might be less dulling.
Posted by g_g_g_unit on June 6, 2010, at 1:41:56
In reply to SSRI's Easy On The Ol' Cognition, posted by Brainbeard on June 6, 2010, at 1:19:56
>
> Sertraline doesn't produce any cognitive debilitation for me. In a study with elderly folks, it actually improved cognition. The SSRI's usually don't impair cognition much, if at all. When I was starting up fluvoxamine (Luvox), it made me terribly slow at work, but that disappeared once my brain got used to the drug.i guess i shouldn't been more patient, though i did give each SRI the requisite 8 weeks. Lexapro and Luvox, in particular, made me feel really foggy; Prozac was neutral, though the sleep disruption at 20mg produced more cognitive s/e's overall.
Posted by Conundrum on June 6, 2010, at 10:46:00
In reply to Re: SSRI's Easy On The Ol' Cognition » Brainbeard, posted by g_g_g_unit on June 6, 2010, at 1:41:56
Maybe 20mg prozac was too high? Many do well at 10 or even 5 mg.
Zoloft, I don't think it is as dulling as lexapro for most ppl.
Posted by SLS on June 8, 2010, at 6:05:52
In reply to Re: My Bloody Regimen, posted by g_g_g_unit on June 6, 2010, at 0:23:25
> >
> >
> >
> > Zoloft is the SSRI that produced the most "brain fog" for me. I was taking 200mg.
> >
> >
> > - Scott
>
> oh strange .. did the effect vary at different doses? which produced the least?
I don't recall the brain fog as being dose-dependent. Perhaps my reaction is atypical.
- Scott
Posted by SLS on June 8, 2010, at 6:10:57
In reply to Re: My Bloody Regimen » SLS, posted by Conundrum on June 6, 2010, at 1:18:10
> Isn't 200mg the highest dose?
Supposedly. I am surprised by how infrequently people reach that dosage. Doctors seem to like 50-100mg. I would continue to increase the dosage of Zoloft to 200mg if it is being tolerated.
- Scott
Posted by Conundrum on June 8, 2010, at 9:33:52
In reply to Re: My Bloody Regimen » Conundrum, posted by SLS on June 8, 2010, at 6:10:57
Perhaps they are aware that too much serotonin is a bad thing and has a flattening effect on mood? Or maybe most patients just do well on 50-100 mg and there is no reason to increase it.
Posted by g_g_g_unit on June 8, 2010, at 10:06:00
In reply to Re: My Bloody Regimen » SLS, posted by Conundrum on June 8, 2010, at 9:33:52
> Perhaps they are aware that too much serotonin is a bad thing and has a flattening effect on mood? Or maybe most patients just do well on 50-100 mg and there is no reason to increase it.
i think you get more DRI at higher doses. im curious about Zoloft. i know someone who is seeing positive gains on just 25mgs. it sounds atypical as far as SSRI's go
Posted by Brainbeard on June 8, 2010, at 11:40:18
In reply to Re: My Bloody Regimen, posted by g_g_g_unit on June 8, 2010, at 10:06:00
The 'S' in 'SSRI' is a bit of a joke.
Prozac is a dopamine and noradrenaline disinhibitor.
Luvox is a potent sigma-1 agonist.
Zoloft is a DRI and also acts on sigma-1 receptors.
Celexa is an antihistaminergic.
Lexapro acts on sigma-1 receptors as well.
Paxil has antihistaminergic and anticholinergic properties and acts on dopamine in higher doses.'RSSRI' would have been a more appropiate name: ' R' for 'Relatively'...
How I love to go off-topic with you guys and gals.
Posted by Brainbeard on June 9, 2010, at 11:35:10
In reply to Truth Is, All SSRI's Are Atypical, posted by Brainbeard on June 8, 2010, at 11:40:18
The online pharmacy wasn't able to deliver my 'Dipergon' (=lisuride) pills since they were 'off the market'. They retransmitted the money. I would like to have known in advance wether my order would be available or not. Big thumb down for this firm. I'm not sure if I'm gonna try again. Maybe I'll just resort to good ol' buspirone for some 5HT1A-agonism.
Posted by Brainbeard on June 10, 2010, at 16:02:29
In reply to Getting On-Topic Again: My Lisuride Order Failed, posted by Brainbeard on June 9, 2010, at 11:35:10
I couldn't restrain myself and ordered another brand of lisuride that ought to be available. Brand name is 'Dopergin'. Sounds dopey, eh?
Posted by Sendow on June 10, 2010, at 16:30:03
In reply to Couldn't help myself and ordered this sh*t again, posted by Brainbeard on June 10, 2010, at 16:02:29
i know dopergin but never tried,i dont had much luck with dopamine agonist... something with Requip maybe.
wut dosage are you start on?
Posted by Brainbeard on June 10, 2010, at 16:50:39
In reply to Re: Couldn't help myself and ordered this sh*t again, posted by Sendow on June 10, 2010, at 16:30:03
Posted by Brainbeard on June 20, 2010, at 13:15:53
In reply to Couldn't help myself and ordered this sh*t again, posted by Brainbeard on June 10, 2010, at 16:02:29
I have tried a small dose of lisuride two times now. A few days ago, I took 0.05mg in the evening. I got a little tense and nervous as I read through some articles in the paper. Later on, I felt mildly euphoric.
Later, I took another 0.05mg during my lunch break at work. Initially, I didn't notice much, but about an hour later, I began to suffer from severe OCD. This wore on well into the next day.
These are baby doses, and it's hard to tell how much of the effects are placebo or coincidence, or caused by some interaction with my other meds. But it seems that lisuride may not be all that easy to adapt to. I'm pretty unstable as it is right now, so I'll probably wait until I'm more stable before I'd start taking it regularly. There may also be the potential of exacerbating OCD..
Posted by CrAzYmEd on June 20, 2010, at 15:38:30
In reply to My first lisuride experiences, posted by Brainbeard on June 20, 2010, at 13:15:53
Low doses will preferentially agonize the presynaptic receptors wich would cause negative effects as it wll lower both serotonine and dopamine.
I know a few ppl that take pramipexole for social anxiety, and the first few weeks are a bit rough.
Anyway very interested to follow your experience
Posted by Brainbeard on June 30, 2010, at 3:08:19
In reply to My first lisuride experiences, posted by Brainbeard on June 20, 2010, at 13:15:53
I'm now taking 0.05mg of lisuride morning, afternoon and evening, so 0.15mg total. I've also started taking selegiline again, 2.5-10mg, and Ritalin every once in a while, 5-15mg, no more, since it is being potentiated by the selegiline.
My experience so far? Lisuride seems to depress mood a little when I don't have a specific task to concentrate on. It may boost libido somewhat. Ever since I take lisuride, I have a greater urge to binge eat to lift my mood, but during and after eating, I feel better only for a short while, and then I feel worse.
I guess I have to wait longer to reap the true benefits. I also consider taking 0.1mg doses instead of 0.05mg. But that's about my limit, since this stuff is too expensive for my taste to take higher doses..
Posted by shasling on July 5, 2010, at 20:56:52
In reply to Re: Also » CrAzYmEd, posted by SLS on May 24, 2010, at 22:42:04
> > My first link to the SAS forum contains evidence that nmda antagonists prevent tolerance to variaty of drugs a collection of all anecdotal reports i found regarding it.
>
> Thanks for all of the information! I'll have to read it later.
>
> Can memantine reverse tolerance after it occurs?
>
>
> - ScottNMDA antagonists being hard to find: memantine a little too mild, amantadine having other effects, on a man; but look at minocycline. It is a mild, easy to get acne antibiotic that happens to have substantial NMDA antagonist properties. Take with magnesium to potentiate.
Posted by Brainbeard on July 12, 2010, at 6:33:55
In reply to Further lisuride experiences, posted by Brainbeard on June 30, 2010, at 3:08:19
Well,I quit my lisuride experiment because of a change of p-doc. I finally have a brilliant p-doc willing to experiment, so I'm willing to adhere to his guidance. Lisuride isn't available on prescription in Holland, so I've ditched it for the time being.
This is the end of the thread.
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