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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Markwell on March 4, 2008, at 7:46:54
I asked this question previously but does anyone have any information on when Agomelatin might be available in the US. Anyone hear any good reports on efficacy?
Posted by rgb on March 10, 2008, at 10:54:39
In reply to Agomelatin, posted by Markwell on March 4, 2008, at 7:46:54
Sorry, can't answer your question directly, but just a thought on agomelatine:
Wikipedia specifically says that it's a 5-HT2C antagonist. If it's really selective for 5-HT2C as opposed to 5-HT2A, this would be a quite interesting add-on to an SSRI. In my dilettantish understanding, 5-HT2C is the main culprit in dopamine inhibition; correct me if I'm wrong. Unfortunately, all other 5-HT2C antagonists I know also block histamine and/or dopamine. I also wouldn't like to antagonize 5-HT2A.
Are there any legal ways of obtaining "no-mans-land" compounds like this? I hope this isn't against the rules, feel free to delete this last paragraph otherwise :)
Posted by Questionmark on April 27, 2008, at 22:29:27
In reply to Agomelatin and 5-HT2C, posted by rgb on March 10, 2008, at 10:54:39
(This would be better on PBabble, no?)
I'm 97% certain that agomelatine is a 5-HT2C antagonist and primarily if not solely selective for that receptor (vs. other 5-HT subtypes).
Yes it would be incredibly interested in trying this and it is a d*** shameful tragedy that the FDA did not approve it. I was looking forward to trying it so much. AHH!
Oh, but i always forget whether 5-HT2C or 5-HT2A receptors are more responsible-- or both relatively equally-- for dopamine inhibition with 5HT-ergic drugs. I believe it's kind of confusing based on a lot of the literature, though, if i remember correctly. Some talk about 5-ht2a being primarily responsible; others 5-ht2c. And then many simply speak of 5-HT2 receptors in general. Ah sorry, yeah that was real helpful.
> Sorry, can't answer your question directly, but just a thought on agomelatine:
>
> Wikipedia specifically says that it's a 5-HT2C antagonist. If it's really selective for 5-HT2C as opposed to 5-HT2A, this would be a quite interesting add-on to an SSRI. In my dilettantish understanding, 5-HT2C is the main culprit in dopamine inhibition; correct me if I'm wrong. Unfortunately, all other 5-HT2C antagonists I know also block histamine and/or dopamine. I also wouldn't like to antagonize 5-HT2A.
>
> Are there any legal ways of obtaining "no-mans-land" compounds like this? I hope this isn't against the rules, feel free to delete this last paragraph otherwise :)
Posted by Markwell on May 22, 2008, at 13:36:56
In reply to Re: Agomelatin and 5-HT2C » rgb, posted by Questionmark on April 27, 2008, at 22:29:27
What do you mean that the FDA hasn't approved it? Have they rejected it or is it still in the approval process? I think this is one I want to try. What phase is it in?
Posted by Negcreep on July 21, 2008, at 6:55:04
In reply to Re: Agomelatin and 5-HT2C, posted by Markwell on May 22, 2008, at 13:36:56
http://en.wikipedia.org/wiki/Agomelatine
Its VERY close to being approved by the EMEA in europe, and is in phase III trials is the US.
This is the end of the thread.
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