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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Lonely on March 25, 2007, at 0:31:34
I just got started on Xolair shots - a humanized monoclonal anitbody that's designed for people with moderate to severe asthma. It prevents IgE, which is found in high levels in very allergic people, from attaching to mast cells thereby reducing or eliminating allergic symptoms.
Is any one else on this or contemplating? I've been to another related board about this too.
I've often wondered if severe allergies plus asthma (and affecting digestion) don't have some impact on one's cognitive processing including mood but most of what I've read seems to deny this. Not sure I'm in agreeement though. Anyone else have experience or insight along these lines?
Posted by Larry Hoover on March 25, 2007, at 10:38:14
In reply to Xolair - New Anti IgE Treatment, posted by Lonely on March 25, 2007, at 0:31:34
> I just got started on Xolair shots - a humanized monoclonal anitbody that's designed for people with moderate to severe asthma. It prevents IgE, which is found in high levels in very allergic people, from attaching to mast cells thereby reducing or eliminating allergic symptoms.
>
> Is any one else on this or contemplating? I've been to another related board about this too.I've not actively considered this therapy, although I've had moderate success with desensitization a decade ago. I'd sure be interested in hearing how you do.
My psych state does correlate rather well with my ability to resist the effects of allergens. I.e., when I'm having a bad allergy season, I'm struggling with mood. A good allergy season is generally part of a more general sense of well-being. I'm pretty sure that my niacinamide/NADH intake might have some influence on this, but I'll need more experimental evidence to really be sure. This year should provide that for me.
> I've often wondered if severe allergies plus asthma (and affecting digestion) don't have some impact on one's cognitive processing including mood but most of what I've read seems to deny this. Not sure I'm in agreeement though. Anyone else have experience or insight along these lines?
I'm surprised you can't find support for this, as there is ample evidence in Pubmed. Here's a couple samples:
Am J Epidemiol. 1999 Nov 15;150(10):1107-16.
Cross-sectional associations of asthma, hay fever, and other allergies with major depression and low-back pain among adults aged 20-39 years in the United States.
Hurwitz EL, Morgenstern H.
Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA.Although low-back pain and depression are common comorbidities, the mechanisms responsible for their association remain unclear. The effects of proinflammatory cytokines on the hypothalamic-pituitary-adrenal (HPA) axis lead to the hypothesis that allergic reactions, as markers for inflammation-associated activation of the HPA axis, result in aberrant responses to subsequent stressors. Data from 6,836 US adults 20-39 years old from the Third National Health and Nutrition Examination Survey (1988-1994) were used. Subjects responded to questions regarding low-back pain in the past 12 months and history of asthma, hay fever, and other allergies. The history and onset of major depression were obtained from the Diagnostic Interview Schedule. Logistic regression modeling was used to estimate the associations between allergies and depression and low-back pain. Subjects with a history of any allergy were more likely to report low-back pain (odds ratio = 1.51; 95% confidence interval: 1.16, 1.96), to be diagnosed with major depression (odds ratio = 1.58; 95% confidence interval: 1.13, 2.21), and much more likely to have both major depression and low-back pain (odds ratio = 3.03; 95% confidence interval: 1.32, 6.92). Hypersensitivity reactions may prime the HPA axis to respond aberrantly to stressors, resulting in physical and behavioral consequences.
Psychother Psychosom. 1991;55(1):24-31.
Depression and allergies: survey of a nonclinical population.
Bell IR, Jasnoski ML, Kagan J, King DS.
Harvard Medical School Department of Psychiatry, McLean Hospital, Belmont, Mass.The possible association between depression and type I allergies (i.e. immunoglobulin E-mediated hay fever, asthma, eczema, hives) was examined in a nonclinical sample of 379 college students. Measures included self-reports of depression, tiredness, fearfulness, allergic disorders, and environmental allergens and irritants. Seventy-one percent of the subjects who had ever received a professional diagnosis of depression also indicated a history of allergy: those with greater self-rated current depression overall reported a significantly higher prevalence of asthma (p less than 0.05). Type I allergic (43%) and nonallergic subjects did not differ in self-rated frequency of depression, fatigue, or anxiety. However, type I subjects reported significantly worse mood after the flu than did nonallergic subjects (p less than 0.001). The data support the hypothesis that individuals prone to clinical depression have more allergies than nondepressives. Allergics may experience more postflu mood worsening but not current depression in comparison with nonallergics.
PMID: 1866437
I think that some allergists just can't see the forest for the trees. They're like the blind men and the elephant, able to interpret only their narrow view of human physiology. Histamine H2 and H4 receptors mediate cytokine release, and we know that cytokines influence mood. It's really not a stretch to link the two. Your beliefs do have scientific support.
Lar
Posted by Lonely on March 25, 2007, at 22:03:04
In reply to Re: Xolair - New Anti IgE Treatment » Lonely, posted by Larry Hoover on March 25, 2007, at 10:38:14
Thanks, Larry. You went to a significant effort to supply me with great information and it is certainly appreciated. I especially found it interesting that people with allergies reported significant depression after the flu - that really describes me to a "T." Unfortunately, with autoimmune problems (for lack of a better description) I have more bouts of flu in a year than most people and it's a real downer.
But, back at Xolair. It's been about 50 hours now since my first dose consisting of two injections - 300 mgs. total. It's based on weight and IgE. My weight is up there after years of gluccocorticoid treatment and my last IgE was 350 - 405 a couple years ago. The desensitization shots were a minor disaster for me during my teens with many bad reactions. They did not help. I had NO problem at all w/Xolair - no swelling at the injection site which surprised me.
So far, the good news is that it seems like, although I don't know if I'm imagining it, that I'm a bit more under control. I spent half of 2 days stomping around in the country and the woods with heavy pollen and dust and bugs and so forth that would normally send me into rashes, sneezing, sinusitis and gasping for breath. I'm not too bad at all and am not taking any extra allergy or asthma med either.
The treatments for allergic asthma are quite toxic, especially after many years so I'm hoping this will eliminate the need either altogether or at least greatly reduce it.
I'm happy to share my experiences with you - just let me know what and when you want to hear about them!
Posted by Declan on April 9, 2007, at 18:56:22
In reply to Re: Xolair - New Anti IgE Treatment » Larry Hoover, posted by Lonely on March 25, 2007, at 22:03:04
I have an IgE of round about 450. I hardly ever have asthma fortunately, but do have the sinus thing which I control with herbs.
Apart from this Xolair stuff, there seems to be no easy way to bring down a high IgE.
I didn't like the sound of the side effects from Xolair, but asthma is no fun either.My doc had a patient with an IgE over 80,000 (if I remember correctly). Her skin was a mess.
With a VERY strict diet and some supplements he got it down to 800.If I really wanted to get mine down I would STRICTLY avoid anything that aggravated my condition.
In particular this means no drugs of any sort, no pullutants. So as you can imagine, it's rather difficult.
I already try to live a healthy life.
Posted by Lonely on April 9, 2007, at 21:55:01
In reply to Re: Xolair - New Anti IgE Treatment, posted by Declan on April 9, 2007, at 18:56:22
Hi -
Thanks for sharing your experiences. I've had two rounds (4 injections) of Xolair now - once every two weeks I have two injections and each injection is 150 mgs. It's been 2+ weeks since I started. Xolair is really complicated and tricky to mix up (no bubbles - took me 40 mins last time) but I've really gotten into the injection part. I like the control of injecting myself and do it at home. Tough part is trying to make sure hubby is around for two hours afterward and *awake*!!They give you a lot of extra sterile water so the last time when I was through with everything I loaded up the big syringe and shot sterile water across the kitchen to see how far it would go .... <big grin>
The first time I had some mild bruises that really did not hurt. This last time I can't even find the injection site on my arm and the one on my tummy is almost microscopic! As far as I can tell there has been no reaction, just my usual allergies which are life altering. My doc says to give it 6 months (some say 3 or 4 months) although I've seen where some people took a year to get relief. Some patients can go off their old meds completely.
I really hope it works as I cannot avoid allergies - I'm allergic to everything in the air and on the earth including molds. I've been diagnosed with allergic bronchopulmonary aspergillosis. The lifetime of treatment has already damaged my lungs and my heart is enlarged so the no-side-effects of xolair is appealing at least so far. It's true that no one knows what will happen 20 years down the road but that's true of many life decisions. Make the best choice with the info at hand.
Posted by Declan on April 10, 2007, at 4:09:58
In reply to Re: Xolair - New Anti IgE Treatment » Declan, posted by Lonely on April 9, 2007, at 21:55:01
I'm allergic to moulds and yeasts too.
Posted by Lonely on April 24, 2007, at 21:43:12
In reply to Re: Xolair - New Anti IgE Treatment » Lonely, posted by Larry Hoover on March 25, 2007, at 10:38:14
Have had 3 series of Xolair shots so far (1-1/2 months) and didn't think it was helping yet at all. Have miserable sinusitis, coughing, stopped up head, running nose, burning tongue, throat, nose, - just misery.
Today I saw my pulmo and my FEV1/I is up from 69.53 back in Oct. to 72.90 today. That means today it was 88.7 % pred and last Oct. it was 84.6%. My FEV1 was up today at 71.5 % Pred from 66.3 % Pred last Oct. My pulmo was delighted although I of course am going "WHAT"? I feel lousy and you're telling me I'm getting better ??? <grin>
Maybe there is something to this - I've heard I should expect 6 months to see improvement and some take a year. The regular treatments for asthma have had significant side effects for me and the naturopathic herbs are often things to which I am allergic!
I heard they're testing Xolair on allergic rhinitis. Although I'm not in a research trial I certainly have all the symptoms and am on Xolair1
Posted by sdb on July 27, 2007, at 17:22:06
In reply to Re: Xolair - New Anti IgE Treatment » Declan, posted by Lonely on April 9, 2007, at 21:55:01
> Hi -
>
> Thanks for sharing your experiences. I've had two rounds (4 injections) of Xolair now - once every two weeks I have two injections and each injection is 150 mgs. It's been 2+ weeks since I started. Xolair is really complicated and tricky to mix up (no bubbles - took me 40 mins last time) but I've really gotten into the injection part. I like the control of injecting myself and do it at home. Tough part is trying to make sure hubby is around for two hours afterward and *awake*!!
>
> They give you a lot of extra sterile water so the last time when I was through with everything I loaded up the big syringe and shot sterile water across the kitchen to see how far it would go .... <big grin>
>
> The first time I had some mild bruises that really did not hurt. This last time I can't even find the injection site on my arm and the one on my tummy is almost microscopic! As far as I can tell there has been no reaction, just my usual allergies which are life altering. My doc says to give it 6 months (some say 3 or 4 months) although I've seen where some people took a year to get relief. Some patients can go off their old meds completely.
>
> I really hope it works as I cannot avoid allergies - I'm allergic to everything in the air and on the earth including molds. I've been diagnosed with allergic bronchopulmonary aspergillosis. The lifetime of treatment has already damaged my lungs and my heart is enlarged so the no-side-effects of xolair is appealing at least so far. It's true that no one knows what will happen 20 years down the road but that's true of many life decisions. Make the best choice with the info at hand.
>
>
>
>
>If your heart is enlarged concentrically or already eccentrically hypertrophied (?) it makes sense to lower your pulmonary resistence. Take care of pulmonary infections (pneumonia). Antibody treatments are still experimental. If there's only one aminoacid structure, glycolisation more thus inconsistency it will have an effect on cells next by.
Good luck with Xolair.
warm regards
sdb
Posted by Lonely on July 28, 2007, at 14:58:46
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely, posted by sdb on July 27, 2007, at 17:22:06
Wow! It's great to have this information and thank you for posting.
On the report it says: "Findings: The heart size is enlarged. There is left atrial enlargement with calcification of the mitral valve. The main pulmonary artery diameter measures 25 mm. The right pulmonary artery diameter measures 19 mm and the left pulmonary artery diameter measures 22 mm." The test was done without contrast and it goes on to describe the lungs.
So, I have no idea if the enlargement was just referring to the left atrial or the whole heart. Is there any way to tell?
If you wouldn't mind, could you explain about the aminoacid structure and glycolisation and the inconsistency it would have on cells nearby? Does this mean that the ultimate effect could be like many meds, that is, cause effects not really intended - i.e., commonly referred to as side effects?
My hubby is on another monoclonal antibody - it's approved by the FDA for limited use in a few centers across the country for MS. Xolair was approved about 3 years ago although many doctors don't seem to really know what I'm talking about when I mention it. I'm still wondering about possible side effects as it seems like body & joint pains were getting worse but ironically responded somewhat to antibiotic for respiratory infection!!!! I've seen a slight improvement in the asthma although every time I get a cold it seems to completely set me back. Sinuses are not helped at all so far. I've also gone up to the max dose - 375 mgs every 2 weeks.
Thanks so much for your insights!
> If your heart is enlarged concentrically or already eccentrically hypertrophied (?) it makes sense to lower your pulmonary resistence. Take care of pulmonary infections (pneumonia). Antibody treatments are still experimental. If there's only one aminoacid structure, glycolisation more thus inconsistency it will have an effect on cells next by.
>
> Good luck with Xolair.
>
> warm regards
>
> sdb
Posted by sdb on July 28, 2007, at 16:51:46
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely » sdb, posted by Lonely on July 28, 2007, at 14:58:46
> Wow! It's great to have this information and thank you for posting.
>
> On the report it says: "Findings: The heart size is enlarged. There is left atrial enlargement with calcification of the mitral valve. The main pulmonary artery diameter measures 25 mm. The right pulmonary artery diameter measures 19 mm and the left pulmonary artery diameter measures 22 mm." The test was done without contrast and it goes on to describe the lungs.
>
> So, I have no idea if the enlargement was just referring to the left atrial or the whole heart. Is there any way to tell?
>
> If you wouldn't mind, could you explain about the aminoacid structure and glycolisation and the inconsistency it would have on cells nearby? Does this mean that the ultimate effect could be like many meds, that is, cause effects not really intended - i.e., commonly referred to as side effects?
>
> My hubby is on another monoclonal antibody - it's approved by the FDA for limited use in a few centers across the country for MS. Xolair was approved about 3 years ago although many doctors don't seem to really know what I'm talking about when I mention it. I'm still wondering about possible side effects as it seems like body & joint pains were getting worse but ironically responded somewhat to antibiotic for respiratory infection!!!! I've seen a slight improvement in the asthma although every time I get a cold it seems to completely set me back. Sinuses are not helped at all so far. I've also gone up to the max dose - 375 mgs every 2 weeks.
>
> Thanks so much for your insights!
>
> > If your heart is enlarged concentrically or already eccentrically hypertrophied (?) it makes sense to lower your pulmonary resistence. Take care of pulmonary infections (pneumonia). Antibody treatments are still experimental. If there's only one aminoacid structure, glycolisation more thus inconsistency it will have an effect on cells next by.
> >
> > Good luck with Xolair.
> >
> > warm regards
> >
> > sdb
>
>Hi lonely!
The heart size is enlarged is unprecise. Did they mesure the ejection fraction (EF). Under <30% it is very bad. If you have difficulty breathing while walking and you have diffuse swelling around the ankles it could be a sign of a
insufficiency. What happen's when your pulmonary resistance is increased continuously? For a longer time your right ventricle will have to pump more until it is no more able to compensate and it will be first hypertrophied due to compensation and then dilated when it is insufficient. That's called cor pulmonale.If you have mitral valve calcification (what diameter (?)) that decreases the ejection fraction during the ventricles diastole into the left ventricle. That means the left atrial pressure increases and because of that it will increase the A. pulmonalis pressure (pap) too (backwards).
heartrate-Volume * pulmonary vascular resistance (pvr) + left atrial pressure (plvo) = mean pressure A. pulmonalis pressure (pap).
A chronic pulmonary hypertension leads to right ventricle insufficiency. But a single mitral valve problem (eg. calcification) or left heart insufficiency will cause pulmonary hypertension too. One thing is clear: If you have left atrial enlargement and calcification of the mitral valve this can cause atrial arrhythmias probably atrial thrombus et cetera. If the left atria is enlarged the lung capillary pressure will be elevated following a right heart stress again and lung oedemas (respiratory problems). Resembles to a vicious circle.
Speak with a good cardiologist but also with a lung specialist about this at best.
Probably first less invasive approach and if necessary there are some invasive approaches. If you have mitralstenosis 50% survive 10 years.
you never had rheumatic fever?
It makes sense to find out what is the reason for your respiratory problems. Theoretically it can be the chronic respiratory problems due to allergens but it could only be the mitral valve problem or both.
Thanks, very interesting information about Xolair.
Will listen to that later.Bye for now,
sdb
ps. i am here in probably a week again.
try to learn the anatomy to understand more.
it make sense to understand before you decide to treat something.http://www.clevelandclinic.org/heartcenter/pub/guide/heartworks/bloodflow.htm
Posted by sdb on July 28, 2007, at 17:01:34
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely, posted by sdb on July 28, 2007, at 16:51:46
corr; mitralstenosis: 50% people survive 10 years. This without treatment (!).
Posted by Lonely on August 1, 2007, at 23:38:26
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely, posted by sdb on July 28, 2007, at 16:51:46
Mmmmm, this sounds scarey! But, don't think my case is that bad, thankfully!
My ejection fraction is 62. My chest does feel a bit tight when walking but think part of it is a chubby tummy pushing against everything else. Also, legs are weak and perhaps getting weaker - not sure why. Legs and ankles not swollen unless shoes are too tight. It says MR "mild." I'm not sure what all this means but LA is 3.0. IVS (d) is 1.2, LPVW is 1.0, IVS (s) is 1.4, LVID(s) is 3.1, and LPVW(s) is 1.2. It also says Normal LV wall motion normal diastolic function. However, the lab that did that test (echocardiogram) missed the fact that my heart was enlarged or else it enlarged over a period of about 4 months. I don't know what the above numbers mean so don't know if atrial is involved in a negative way or not.
As far as I know, I never had rheumatic fever but it's always possible I had a mild case and it was overlooked.
I just had another pft and am now considered "normal." (!!!) But, I take a lot of pseudoephedrine for chronic sinusitis - sure hope xolair helps out there. ...wondering what pseudoephedrine does to my heart.
I'm still curious, though, about the effect antibodies have on nearby cells. Could you elaborate a bit more? I'm always wondering what more xolair could be doing!
Thanks and welcome back when you arrive!
Posted by sdb on August 8, 2007, at 20:08:22
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely » sdb, posted by Lonely on August 1, 2007, at 23:38:26
Dear Sir
This with the cells nearby is difficult to explain here.
LA = Left Atrium
IVS = Interventricular Septum
LVEDV = Relative left ventricular end-diastolic volume
rel.LVID = Relative left ventricular internal diameter
Take care and be sure to be in a good treatment. Educate yourself a little bit about all these parameters.There is a very easy understandable book about primarily lungs and heart (always connected these two organs):
You're free to babble-mail your e-mail address so I can send you a standard not clinical book in *.pdf file format about "immunology". There is a chapter about allergies and so on. But it's not about treatment is only to understand the things with the cells. I have some other books also.
I will be here in a week again.
Always warm regards
sdb
> Mmmmm, this sounds scarey! But, don't think my case is that bad, thankfully!
>
> My ejection fraction is 62. My chest does feel a bit tight when walking but think part of it is a chubby tummy pushing against everything else. Also, legs are weak and perhaps getting weaker - not sure why. Legs and ankles not swollen unless shoes are too tight. It says MR "mild." I'm not sure what all this means but LA is 3.0. IVS (d) is 1.2, LPVW is 1.0, IVS (s) is 1.4, LVID(s) is 3.1, and LPVW(s) is 1.2. It also says Normal LV wall motion normal diastolic function. However, the lab that did that test (echocardiogram) missed the fact that my heart was enlarged or else it enlarged over a period of about 4 months. I don't know what the above numbers mean so don't know if atrial is involved in a negative way or not.
>
> As far as I know, I never had rheumatic fever but it's always possible I had a mild case and it was overlooked.
>
> I just had another pft and am now considered "normal." (!!!) But, I take a lot of pseudoephedrine for chronic sinusitis - sure hope xolair helps out there. ...wondering what pseudoephedrine does to my heart.
>
> I'm still curious, though, about the effect antibodies have on nearby cells. Could you elaborate a bit more? I'm always wondering what more xolair could be doing!
>
> Thanks and welcome back when you arrive!
>
>
>
Posted by sdb on August 8, 2007, at 20:15:42
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely, posted by sdb on August 8, 2007, at 20:08:22
> Dear Sir
>
> This with the cells nearby is difficult to explain here.
>
> LA = Left Atrium
>
> IVS = Interventricular Septum
>
> LVEDV = Relative left ventricular end-diastolic volume
>
> rel.LVID = Relative left ventricular internal diameter
>
>
> Take care and be sure to be in a good treatment. Educate yourself a little bit about all these parameters.
>
> There is a very easy understandable book about primarily lungs and heart (always connected these two organs):
>
> http://www.amazon.com/Respiratory-System-Glance-Oxford-England/dp/1405134488/ref=sr_1_1/102-9423039-0704945?ie=UTF8&s=books&qid=1186620181&sr=8-1
>
> You're free to babble-mail your e-mail address so I can send you a standard not clinical book in *.pdf file format about "immunology". There is a chapter about allergies and so on. But it's not about treatment is only to understand the things with the cells. I have some other books also.
>
> I will be here in a week again.
>
> Always warm regards
>
> sdb
>
> > Mmmmm, this sounds scarey! But, don't think my case is that bad, thankfully!
> >
> > My ejection fraction is 62. My chest does feel a bit tight when walking but think part of it is a chubby tummy pushing against everything else. Also, legs are weak and perhaps getting weaker - not sure why. Legs and ankles not swollen unless shoes are too tight. It says MR "mild." I'm not sure what all this means but LA is 3.0. IVS (d) is 1.2, LPVW is 1.0, IVS (s) is 1.4, LVID(s) is 3.1, and LPVW(s) is 1.2. It also says Normal LV wall motion normal diastolic function. However, the lab that did that test (echocardiogram) missed the fact that my heart was enlarged or else it enlarged over a period of about 4 months. I don't know what the above numbers mean so don't know if atrial is involved in a negative way or not.
> >
> > As far as I know, I never had rheumatic fever but it's always possible I had a mild case and it was overlooked.
> >
> > I just had another pft and am now considered "normal." (!!!) But, I take a lot of pseudoephedrine for chronic sinusitis - sure hope xolair helps out there. ...wondering what pseudoephedrine does to my heart.
> >
> > I'm still curious, though, about the effect antibodies have on nearby cells. Could you elaborate a bit more? I'm always wondering what more xolair could be doing!
> >
> > Thanks and welcome back when you arrive!
> >
> >
> >
>
>I can send you cardiovascular system at a glance per e-mail. It is very easy to understand and costless (it's support...). Other books are complicated.
sdb, busy
Posted by sdb on August 17, 2007, at 6:05:50
In reply to Re: Xolair - New Anti IgE Treatment }} Lonely, posted by sdb on August 8, 2007, at 20:15:42
> > Dear Sir
> >
> > This with the cells nearby is difficult to explain here.
> >
> > LA = Left Atrium
> >
> > IVS = Interventricular Septum
> >
> > LVEDV = Relative left ventricular end-diastolic volume
> >
> > rel.LVID = Relative left ventricular internal diameter
> >
> >
> > Take care and be sure to be in a good treatment. Educate yourself a little bit about all these parameters.
> >
> > There is a very easy understandable book about primarily lungs and heart (always connected these two organs):
> >
> > http://www.amazon.com/Respiratory-System-Glance-Oxford-England/dp/1405134488/ref=sr_1_1/102-9423039-0704945?ie=UTF8&s=books&qid=1186620181&sr=8-1
> >
> > You're free to babble-mail your e-mail address so I can send you a standard not clinical book in *.pdf file format about "immunology". There is a chapter about allergies and so on. But it's not about treatment is only to understand the things with the cells. I have some other books also.
> >
> > I will be here in a week again.
> >
> > Always warm regards
> >
> > sdb
> >
> > > Mmmmm, this sounds scarey! But, don't think my case is that bad, thankfully!
> > >
> > > My ejection fraction is 62. My chest does feel a bit tight when walking but think part of it is a chubby tummy pushing against everything else. Also, legs are weak and perhaps getting weaker - not sure why. Legs and ankles not swollen unless shoes are too tight. It says MR "mild." I'm not sure what all this means but LA is 3.0. IVS (d) is 1.2, LPVW is 1.0, IVS (s) is 1.4, LVID(s) is 3.1, and LPVW(s) is 1.2. It also says Normal LV wall motion normal diastolic function. However, the lab that did that test (echocardiogram) missed the fact that my heart was enlarged or else it enlarged over a period of about 4 months. I don't know what the above numbers mean so don't know if atrial is involved in a negative way or not.
> > >
> > > As far as I know, I never had rheumatic fever but it's always possible I had a mild case and it was overlooked.
> > >
> > > I just had another pft and am now considered "normal." (!!!) But, I take a lot of pseudoephedrine for chronic sinusitis - sure hope xolair helps out there. ...wondering what pseudoephedrine does to my heart.
> > >
> > > I'm still curious, though, about the effect antibodies have on nearby cells. Could you elaborate a bit more? I'm always wondering what more xolair could be doing!
> > >
> > > Thanks and welcome back when you arrive!
> > >
> > >
> > >
> >
> >
>
> I can send you cardiovascular system at a glance per e-mail. It is very easy to understand and costless (it's support...). Other books are complicated.
>
> sdb, busyI mean (it's support...) because of copyright reasons also. But if you're trying to give people information to understand more about a suffering I am sure some companies don't need the money for a 22th edition.
This is the end of the thread.
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