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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Netch on August 29, 2007, at 8:46:58
Glycine is known to be a major inhibitory neurotransmitter in the brainstem and spinal cord
but it's also known to function as a coagonist at the NMDA receptor.
Studies have shown that glycine alleviate negative symptoms in schizophrenia, possibly through NMDA receptor stimulation.
On the other hand NMDA receptor antagonists have antidepressant-like activity.Does this make sense?
Posted by nolvas on August 29, 2007, at 14:25:05
In reply to Glycine and the NMDA receptor, posted by Netch on August 29, 2007, at 8:46:58
Have a look at cycloserine (seromycin) side effects include depression. Cycloserine is a partial agonist of the NDMA receptor for glutamate Glycine could be described as poor man's cycloserine maybe? Large amounts of Glycine have to be ingested to have an effect on schizophrenia. I am interested in cycloserine with regard to fear extinction. However I imagine it's impossible to obtain in the UK where I live.
Posted by Netch on August 30, 2007, at 9:00:18
In reply to Re: Glycine and the NMDA receptor, posted by nolvas on August 29, 2007, at 14:25:05
Hi Nolvas
I just think it's weird that an agonist of the NDMA receptor could induce/worsen depression and at the same time be effective on negative symptoms of schizophrenia, which in many ways are similar to depressive symptoms.
Netch
> Have a look at cycloserine (seromycin) side effects include depression. Cycloserine is a partial agonist of the NDMA receptor for glutamate Glycine could be described as poor man's cycloserine maybe? Large amounts of Glycine have to be ingested to have an effect on schizophrenia. I am interested in cycloserine with regard to fear extinction. However I imagine it's impossible to obtain in the UK where I live.
Posted by linkadge on August 30, 2007, at 13:42:44
In reply to Re: Glycine and the NMDA receptor » nolvas, posted by Netch on August 30, 2007, at 9:00:18
From what I understand, glycine doesn't always act as an agonist of NMDA. Some studies show it acts as an agonist only under conditions of hypo-NMDA function.
Linkadge
Posted by Netch on August 31, 2007, at 3:39:03
In reply to Re: Glycine and the NMDA receptor, posted by linkadge on August 30, 2007, at 13:42:44
Link, it seems like glycine is only a co-agonist of glutamate at the NMDA receptor. So if glutamate is avoided maybe the potential depressive effect of glycine can be avoided.
I've read that glycine alleviates manic depressions in 'moderate' doses (1-3 gram)Netch
Posted by linkadge on August 31, 2007, at 11:47:31
In reply to Re: Glycine and the NMDA receptor » linkadge, posted by Netch on August 31, 2007, at 3:39:03
Yeah, glycine and taurine are good for bipolar disorder.
Linkadge
Posted by Alvin on August 31, 2007, at 14:46:55
In reply to Re: Glycine and the NMDA receptor, posted by linkadge on August 31, 2007, at 11:47:31
I have bipolar II rapid cycling; i have been on 100 mg lamictal, 20 mg geodon, 20 mg prozac, .25 mg requip 2x daily, and ativan as needed.
Recently, my pdoc has begun to look at alternative meds, and suggested tryptophan for me, which has helped my depression.
He also suggested I increase my lamictal to 200 mg, but before I do that, I want to try glycine and taurine. What dose would you suggest to start with? Can I get these at Vitamin World? I'd like to start as soon as possible before I see my pdoc on the 11th.
Posted by nolvas on August 31, 2007, at 17:54:03
In reply to Lars, Linkadge or Netch? Dose glycine taurine?, posted by Alvin on August 31, 2007, at 14:46:55
Hi Alvin, you will find Taurine easily. Glycine is a little harder. I would dispense with the idea of using vitamin world though and buy the powder in bulk from www.bulknutrition.com , www.jomarlabs.com (especially recommended) or even www.iherb.com.
Bulk powder is cheap, you know there's no fillers to bind the contents in to a pill, and it's quite easy to get the dosage ok even just using a teaspoon. Jomarlabs usually give you the approximate weight. For example "The powder weighs about 4.6 grams per level measuring teaspoon. "
Glycine > "The powder is soluble in water and weighs about 4.4 grams per level measuring teaspoon."
Posted by Netch on September 1, 2007, at 4:13:57
In reply to Lars, Linkadge or Netch? Dose glycine taurine?, posted by Alvin on August 31, 2007, at 14:46:55
Alvin, I would suggest starting with 500 mg x 3 of taurine and glycine. Total daily dose for each AA is usually 1-3 gram for bipolar disorders. Another alternative mood stabilizer is lithium orotate (5-20 mg elemental lithium)
Netch
> I have bipolar II rapid cycling; i have been on 100 mg lamictal, 20 mg geodon, 20 mg prozac, .25 mg requip 2x daily, and ativan as needed.
>
> Recently, my pdoc has begun to look at alternative meds, and suggested tryptophan for me, which has helped my depression.
>
> He also suggested I increase my lamictal to 200 mg, but before I do that, I want to try glycine and taurine. What dose would you suggest to start with? Can I get these at Vitamin World? I'd like to start as soon as possible before I see my pdoc on the 11th.
Posted by Alvin on September 5, 2007, at 16:08:37
In reply to Re: Lars, Linkadge or Netch? Dose glycine taurine? » Alvin, posted by Netch on September 1, 2007, at 4:13:57
Thanks Netch. Do you have any preference, for example you mentioned lithium orotate? Do you prefer that to taurine and glycine?
Have there been studies on the effectiveness of any of these AAs and lithium orotate for bipolar rapid cycling? Or is it mostly anecdotal?
> Alvin, I would suggest starting with 500 mg x 3 of taurine and glycine. Total daily dose for each AA is usually 1-3 gram for bipolar disorders. Another alternative mood stabilizer is lithium orotate (5-20 mg elemental lithium)
>
> Netch
>
> > I have bipolar II rapid cycling; i have been on 100 mg lamictal, 20 mg geodon, 20 mg prozac, .25 mg requip 2x daily, and ativan as needed.
> >
> > Recently, my pdoc has begun to look at alternative meds, and suggested tryptophan for me, which has helped my depression.
> >
> > He also suggested I increase my lamictal to 200 mg, but before I do that, I want to try glycine and taurine. What dose would you suggest to start with? Can I get these at Vitamin World? I'd like to start as soon as possible before I see my pdoc on the 11th.
>
>
Posted by Netch on September 8, 2007, at 3:17:17
In reply to Re: Lars, Linkadge or Netch? Dose glycine taurine?, posted by Alvin on September 5, 2007, at 16:08:37
Alvin, I actually recommend all of them. All have stimulating effects without the stress factor. I think the one helping me the least is probably glycine but I may be wrong, since glycine is the last AA I added it's kind of hard to tell.
Netch
> Thanks Netch. Do you have any preference, for example you mentioned lithium orotate? Do you prefer that to taurine and glycine?
>
> Have there been studies on the effectiveness of any of these AAs and lithium orotate for bipolar rapid cycling? Or is it mostly anecdotal?
>
> > Alvin, I would suggest starting with 500 mg x 3 of taurine and glycine. Total daily dose for each AA is usually 1-3 gram for bipolar disorders. Another alternative mood stabilizer is lithium orotate (5-20 mg elemental lithium)
> >
> > Netch
> >
> > > I have bipolar II rapid cycling; i have been on 100 mg lamictal, 20 mg geodon, 20 mg prozac, .25 mg requip 2x daily, and ativan as needed.
> > >
> > > Recently, my pdoc has begun to look at alternative meds, and suggested tryptophan for me, which has helped my depression.
> > >
> > > He also suggested I increase my lamictal to 200 mg, but before I do that, I want to try glycine and taurine. What dose would you suggest to start with? Can I get these at Vitamin World? I'd like to start as soon as possible before I see my pdoc on the 11th.
> >
> >
>
>
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