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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by qqqsimmons on January 21, 2007, at 19:58:51
i can't say for certain that riboflavin boosts MAO activity, but riboflavin's relative FAD (flavin adenine dinucleotide) is a cofactor of MAO...
and, after a week of tinkering with riboflavin, i can say that i'm feel more anxious, and pangs of despair have been more frequent the past couple of days.
perhaps riboflavin-induced low serotonin levels are to blame? best boosters i have on hand are fish oil or st johns wort...
i'm just guessing here...this is what happens when you're take too many supps at one time...
Posted by guardianangel on January 26, 2007, at 12:08:11
In reply to re: riboflavin / monoamine oxidase, posted by qqqsimmons on January 21, 2007, at 19:58:51
B2 is necessary for the activation of B6 to pyridoxal-5phosphate coenzyme.This cofactor then catalyzes the formation of dopamine and serotonin from LDOPA and tryptophan resp. so your anxiety is more likely to be the result of increased monoamine neurotransmitters than anything else....
Posted by qqqsimmons on January 26, 2007, at 17:48:08
In reply to re: riboflavin / monoamine oxidase, posted by qqqsimmons on January 21, 2007, at 19:58:51
interesting, but B2 is also a precursor to FAD, a primary cofactor for MAO. not sure which wins out in the end.
Posted by guardianangel on January 29, 2007, at 4:48:57
In reply to re: riboflavin / monoamine oxidase, posted by qqqsimmons on January 26, 2007, at 17:48:08
what could be happening here is that whilst P5P is acting to upregulate DA biosynthesis, FAD-induced MAO stimulation is accelerating catabolism or conversion of DA to the anxiogen NA...
5HT levels would also be expected to suffer from MAO activity in favour of its (methylated) tryptamine or kynurenine(?) derivatives which are also anxiogens
Afterall without enough dietary P5P tryptophan gets converted into the anxiogen kynurenine...
Just a thought
Posted by linkadge on January 30, 2007, at 16:03:29
In reply to re: riboflavin / monoamine oxidase, posted by guardianangel on January 29, 2007, at 4:48:57
Increased monoamine oxidase would decrease bioactivity of PEA which can be highly anxiogenic. MAO inhibitors are notorious for causing insomnia.
Wouldn't increaseing MAO also decrease brain levels of tryptamine as MAO inhibitors prolong the biological activity of tryptamine?
There are a number of other trace amines with high binging to the amygdala which are elevated with monoamine oxdiase inhibition.
Dispite the efficacy of Nardil in GAD, monoamine oxidase inhibitors can be highly anxiogenic. Consider the endogenious MAO inhibitor isatin. It is increased by stress, and can prolong the psychological response to stress.
My main reason for wanting to increase monoamine oxidase was to counteract the decrease in monoamine oxidase caused by exercise indused isatin increase.
Linkadge
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