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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Jimmyboy on December 30, 2006, at 14:35:03
NM
Posted by linkadge on December 30, 2006, at 17:58:30
In reply to Why would folic acid help depression?, posted by Jimmyboy on December 30, 2006, at 14:35:03
Folic acid is needed for the synthesis of ser/nor/dopamine, as well it is used in the synthesis of SAMe.
I think folic acid is also critical for neurogenesis. Supposedly slight deficiancies can reduce hippocampal proliferation.
Linakdge
Posted by dessbee on January 5, 2007, at 11:53:41
In reply to Why would folic acid help depression?, posted by Jimmyboy on December 30, 2006, at 14:35:03
Folate is needed to replicate DNA/RNA and may improve neurogenesis.
Folate deficiency will affect cell division, especially cells with rapid cycles like formation of red blood cells.Folate is used in the Methionine Metabolic Pathway to regenerate methionine from homocysteine, which is a risk factor for depression.
Folate may increase S-adenosylmethionine (SAMe) through the replenishment of methionine.
S-adenosylmethionine (SAMe) is used in the synthesis of epinephrine.Folate is not directly involved in synthesis of serotonin/dopamine/epinephrine
Folate can increase histamine levels, which may aggrevate sleep quality and increase inflammatory processes.
Posted by linkadge on January 5, 2007, at 16:42:16
In reply to Re: Why would folic acid help depression? » Jimmyboy, posted by dessbee on January 5, 2007, at 11:53:41
Acording to LEF.
http://www.lef.org/magazine/mag2005/jan2005_report_same_01.htm
SAMe:
As a methyl donor, it enables the brain to manufacture vital neurotransmitters, including dopamine, serotonin, and norepinephrine from substrate molecules.
Would this not implicate folate in the synthesis of serotonin?
Linkadge
Posted by dessbee on January 8, 2007, at 5:44:20
In reply to Re: Why would folic acid help depression?, posted by linkadge on January 5, 2007, at 16:42:16
You should not trust everything on the Internet.
Same is only involved in epinephrine synthesis.
Posted by linkadge on January 8, 2007, at 14:00:53
In reply to Re: Why would folic acid help depression? » linkadge, posted by dessbee on January 8, 2007, at 5:44:20
Do you have any references that suggest that SAMe is *only* involved in the synthesis of epiniephrine?
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http://www.cmaj.ca/cgi/reprint/166/2/205.pdf"There is a connection between SAMe and serotonin because folate deficiancy can decrease serotonin synthesis in rats and humans, wherase SAMe can increase serotonin synthesis in rats and humans"
"The mechanism of the link between SAMe and serotonin is unknown. SAMe is involved
in over 35 methylation reactions,16 so the possibilities are many."- Young SN, Ghadirian AM. Folic acid and psychopathology. Prog Neuropsychopharmacol
Biol Psychiatry 1989;13:841-63.-------
PubMedhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=543840
Administration of SAMe increases cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) in humans4 and brain serotonin in rats,5,6 although the mechanism of this connection between SAMe and serotonin is unknown.
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SAMe augmentation of clomipramine causing serotonin syndrome.
: Iruela LM, Minguex L, Merino J, et al. Toxic interaction of S-adenosylmethionine and clomipramine [letter]. Am J Psychiatry. 1993;150:522.
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http://www.psycom.net/depression.central.same.html
Folic acid deficiency causes a lowering of brain serotonin in rats,
and of cerebrospinal fluid 5-hydroxyindoleacetic acid in humans.-------
Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
http://www.psycom.net/depression.central.same.html
"and S-adenosylmethionine is an antidepressant that raises brain serotonin levels"...
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Affective illness and S-adenosyl methionine: a preliminary report
The indications are that SAM specifically affects folate, dopamine, and serotonin metabolism as well as activating and switching brain
mechanisms--------
U of Maryland Medical Centre:
http://www.umm.edu/altmed/ConsSupplements/SAdenosylmethionineSAMecs.html
http://biopsychiatry.com/samerev.htm
" SAMe is a methyl donor and is involved in the synthesis of various neurotransmitters in the brain."
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http://biopsychiatry.com/sameart.html
"SAMe may enhance the impact of mood-boosting messengers such as serotonin and dopamine—either by regulating their breakdown or by speeding production of the receptor molecules they latch on to. SAMe may also make existing receptors more responsive."
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"Methylation occurs a billion times a second throughout the body, affecting everything from fetal development to brain function. It regulates the expression of genes. It preserves the fatty membranes that insulate our cells. And it helps regulate the action of various hormones and neurotransmitters, including serotonin, melatonin, dopamine and adrenaline. As biochemist Craig Cooney observes in his new book, "Methyl Magic," "Without methylation there could be no life as we know it."
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http://www.wandb.com/cgi-bin/shop.pl/page=SAMe.htm
SAMe is necessary in the manufacture of neurotransmitter phospholipids, such as phosphatidylcholine and phosphatidylserine. Additionally, studies show that SAMe can increase levels of the important neurotransmitters serotonin, norepinephrine, dopamine and phosphatidylserine. It has been shown to improve the binding of neurotransmitters to receptor sites, thus increasing brain neurotransmitters, such as serotonin.
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Linkadge
Posted by dessbee on January 8, 2007, at 14:27:54
In reply to Re: Do you have references? » dessbee, posted by linkadge on January 8, 2007, at 14:00:53
This seems to concern you a great deal ;-)http://web.indstate.edu/thcme/mwking/aminoacidderivatives.html
Posted by linkadge on January 8, 2007, at 14:58:48
In reply to Re: Do you have references? » linkadge, posted by dessbee on January 8, 2007, at 14:27:54
Doesn't concern me that much, but I do think I am going to stick to what my own reading has led me to believe.
Linkadge
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