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Dr. Bob is Robert Hsiung, MD,
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Posted by Tomatheus on November 25, 2006, at 15:44:38
Does anyone here know of any natural COMT inhibitors other than green tea and quercetin?
Green tea tends to make me feel sleepy, which I suspect may be due to the fact that it contains l-theanine. Of course, the fact that green tea tends to make me feel sleepy could be due to some mechanism that's unrelated to the effects of l-theanine or a combination of mechanisms. But whatever it is in green tea that causes me to feel sleepy, I don't think that it's the chemical that inhibits COMT; I suspect that the sleepiness-inducing effect is probably counteracting the effect that I would get from COMT inhibition.
I tried taking some quercetin yesterday (1800 mg worth), and it didn't seem to have much of an effect on me whatsoever. I suspect that this may be due to the possibility that the form of quercetin that I took may not be absorbed into the bloodstream as readily as isoquercitrin (quercetin-3-0-glucoside), which is supposedly the most bio-available form of quercetin. But there could be other explanations. Maybe I just haven't given the quercetin enough of a chance yet.
So, obviously green tea and quercetin and two options as far as natural COMT inhibition goes. But are there any others?
Tomatheus
Posted by blueberry on November 26, 2006, at 7:12:22
In reply to Natural COMT inhibitors, posted by Tomatheus on November 25, 2006, at 15:44:38
I saw somewhere that Rhodiola Rosea has COMT inhibition mechanisms. But it has other mechanisms too which may or may not be of interest to you.
Posted by Meri-Tuuli on November 26, 2006, at 12:46:20
In reply to Re: Natural COMT inhibitors, posted by blueberry on November 26, 2006, at 7:12:22
> I saw somewhere that Rhodiola Rosea has COMT inhibition mechanisms. But it has other mechanisms too which may or may not be of interest to you.
Yeah this is what I found too. They don't really know how rhodiola rosea works, they do reckon at COMT inhib. It feels rather like a stimulant through.
Posted by Tomatheus on December 1, 2006, at 0:18:14
In reply to Re: Natural COMT inhibitors, posted by Meri-Tuuli on November 26, 2006, at 12:46:20
Blueberry & Meri-Tuuli,
Thank you for the information on rhodiola rosea. I was not aware of the fact that rhodiola has been shown to have COMT-inhibiting properties -- my knowledge of the herb's mechanisms is rather limited -- and it's helpful to know that it does.
A while back, I did come across a study on rhodiola that suggested that the herb has cholinergic properties, which is the main reason why I haven't tried it as of yet. Cholinergic meds and supplements that I've taken in the past seem to aggravate the melancholic/anxious aspect of my depressive disorder (which I now believe is a double depression with both melancholic and atypical components), causing me to experience feelings of akathisia. But I guess it's conceivable that rhodiola's cholinergic effects might be relatively weak and that its benefits might outweigh its drawbacks.
So, I may consider giving rhodiola a try at some point in the future, considering that it has COMT-inhibiting properties. It's still not next on my list of things to try, but I think it might be worth a try if other options fail.
Thanks again for the info.
Tomatheus
> > I saw somewhere that Rhodiola Rosea has COMT inhibition mechanisms. But it has other mechanisms too which may or may not be of interest to you.
>
> Yeah this is what I found too. They don't really know how rhodiola rosea works, they do reckon at COMT inhib. It feels rather like a stimulant through.
Posted by linkadge on December 2, 2006, at 12:05:22
In reply to Re: Natural COMT inhibitors, posted by Tomatheus on December 1, 2006, at 0:18:14
resveratrol ?
Linkadge
Posted by Tomatheus on December 5, 2006, at 7:51:33
In reply to Re: Natural COMT inhibitors, posted by linkadge on December 2, 2006, at 12:05:22
> resveratrol ?
>
> LinkadgeHmmm...
That sounds like it might be worth considering. Thanks for the suggestion.
Tomatheus
This is the end of the thread.
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