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Dr. Bob is Robert Hsiung, MD,
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Posted by qqqsimmons on November 6, 2006, at 18:25:45
i took a bunch of mag yesterday and laid awake for hours before taking some benedryl&taurine to finally put me down.
i wonder if some of the reverse effects of magnesium (insomnia and uh...insomnia) aren't related to adrenaline suppression via COMT.
maybe it's like how beta blockers suppress adrenaline and inadvertedly wind up messing up folks melatonin...so that even though they're tired all the time, they can't fricking sleep at night.
is our melatonin release at night dependent on a certain amount of adrenal action during the day?
Posted by kiwiredbeach on November 7, 2006, at 3:08:27
In reply to magnesium insomnia, posted by qqqsimmons on November 6, 2006, at 18:25:45
> i took a bunch of mag yesterday and laid awake for hours before taking some benedryl&taurine to finally put me down.
>
> i wonder if some of the reverse effects of magnesium (insomnia and uh...insomnia) aren't related to adrenaline suppression via COMT.
>
> maybe it's like how beta blockers suppress adrenaline and inadvertedly wind up messing up folks melatonin...so that even though they're tired all the time, they can't fricking sleep at night.
>
> is our melatonin release at night dependent on a certain amount of adrenal action during the day?Very good question, Ive found the same thing with magnesium that my sleep was shorter. Ive now come to the conclusion taking a large dose of magnesium at one time is a bad idea. When I found out through blood tests that i was short of magnesium (and I have very low levels tested hair, sweat, plasma, blood cells) I started taking large doses which had the effect that It stoped my panic attacks dead, however the effect of this is that im feeling very depressed, because I suspect my addrenal system is now to low. Ive stoped taking magnesium for the moment (which has helped my depression) and will introduce it back into my system slowly, ie 50mg week one, 100 mg week 2 and 3, 150 mg week 4 and 5 etc etc. Im sure that being magnesium defient has played a major role in my problems with anxiety. I think that you have to let your body get use to a mineral that its been defient in. After 300 to 400 mg a day of magnesuim it put my whole system into reverse
depression never seemed to be my problem just anxiety. Ive also heard that some forms of magnesium can be very activating, whatever chemical is bounded to the magnesium makes a difference. I was taking magnesium phosphate which ive now heard is not the best, phosphate is activating so I will be trying another version.Cheers Kiwiredbeach
Posted by Meri-Tuuli on November 7, 2006, at 9:28:41
In reply to Re: magnesium insomnia, posted by kiwiredbeach on November 7, 2006, at 3:08:27
I was under the impression that mag was supposed to be a 'relaxing' mineral, and was best taken before bed, etc etc. ?
Posted by Tomatheus on November 9, 2006, at 18:25:29
In reply to magnesium insomnia, posted by qqqsimmons on November 6, 2006, at 18:25:45
> maybe it's like how beta blockers suppress adrenaline and inadvertedly wind up messing up folks melatonin...so that even though they're tired all the time, they can't fricking sleep at night.
>
> is our melatonin release at night dependent on a certain amount of adrenal action during the day?Actually, I remember reading a medical journal article stating that stimulation of the beta receptor is a necessary step in the synthesis of melatonin. I don't have the article with me right now, but if you need a citation, let me know, and I'll get you the info.
I personally suspect that the beta receptor's role in the production of melatonin could be part of the reason why meds that inhibit the reuptake of norepinephrine seem to have a paradoxical depressant effect (or at least an inconsistent antidepressant) effect in some individuals. That's basically just a wild theory of mine, though, not any kind of authoritative knowledge.
Tomatheus
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