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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by linkadge on April 29, 2006, at 19:11:20
Kindof like Tianeptine.
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The Ginkgo biloba extract, EGb761, increases synaptosomal uptake of 5- hydroxytryptamine: in-vitro and ex-vivo studies.
In: J Pharm Pharmacol (1992 Nov) 44(11):943-5
The Ginkgo biloba extract (EGb 761) added to a synaptosomal fraction prepared from mice cerebral cortex modified [3H]5-hydroxytryptamine ([3H]5-HT) uptake in a biphasic manner. Between 4 and 16 micrograms mL-1 EGb 761 increased significantly the [3H]5-HT uptake (maximum + 23%). A similar increase was also obtained when synaptosomes were prepared from the cortex of mice treated orally with EGb 761, either acutely (100 mg kg-1, 14 h and 2 h before death) or semi-chronically (2 x 100 mg-1 kg daily for 4 consecutive days). The in-vitro increase in [3H]5-HT uptake induced by EGb 761 was not observed in the presence of 10(-6) M clomipramine, a 5-HT-uptake inhibitor. EGb 761 did not increase [3H]dopamine uptake by synaptosomes prepared from striatum of mice. We investigated different fractions of EGb 761 in order to determine the compounds inducing the increase in [3H]5-HT uptake. The BN 52063 extract (corresponding to the EGb 761 devoid of flavonoid substances) did not increase [3H]5-HT uptake. The Cp 202 extract (corresponding to the EGb 761 devoid of terpenic substances and containing mostly flavonoid substances) increased [3H]5-HT uptake. Among the flavonoids, quercetin has been tested and had no effect on the [3H]5-HT uptake. Since at the usual therapeutic doses of EGb 761, the effective concentrations of the components responsible for this increase are likely to be reached in the brain, one may suggest that this effect could contribute to the therapeutic effect of EGb 761.
Linkadge
Posted by LOOPS on May 13, 2006, at 19:48:47
In reply to Ginkgo increase serotonin uptake, posted by linkadge on April 29, 2006, at 19:11:20
Do you know why ginkgo makes me so hungry? It also makes me really motivated (too much so!) - usually serotonin stuff makes me relaxed and non-interested. It must be very complicated.
Loops
Posted by Questionmark on May 21, 2006, at 1:03:34
In reply to Re: Ginkgo increase serotonin uptake, posted by LOOPS on May 13, 2006, at 19:48:47
Wow, interesting info. ... Wait, this was from 1992? Why hasn't it been more widely discussed that Gingko extract is/can be a serotonin reuptake enhancer?
> Do you know why ginkgo makes me so hungry? It also makes me really motivated (too much so!) - usually serotonin stuff makes me relaxed and non-interested. It must be very complicated.
>
> LoopsThis is totally compatible with the abstract. It shows that Ginkgo extract probably has serotonin uptake *increasing* properties, therefore resulting in less intrasynaptic serotonin (i.e., it works the opposite of SSRIs and similar to tianeptine/Stablon).
Posted by Larry Hoover on May 30, 2006, at 9:23:05
In reply to Re: Ginkgo increase serotonin uptake, posted by Questionmark on May 21, 2006, at 1:03:34
> Wow, interesting info. ... Wait, this was from 1992? Why hasn't it been more widely discussed that Gingko extract is/can be a serotonin reuptake enhancer?
Good question, but I bet the answer is right in front of us. The opening sentence of the abstract says: "The Ginkgo biloba extract (EGb 761) ... modified [3H]5-hydroxytryptamine ([3H]5-HT) uptake in a biphasic manner." Then they go on to only describe one phase.
They didn't tell us about the other dose-response effect. I'm going to have to presume it was not a positive effect, without having a chance to read the entire paper.
> > Do you know why ginkgo makes me so hungry? It also makes me really motivated (too much so!) - usually serotonin stuff makes me relaxed and non-interested. It must be very complicated.
> >
> > Loops
>
> This is totally compatible with the abstract. It shows that Ginkgo extract probably has serotonin uptake *increasing* properties, therefore resulting in less intrasynaptic serotonin (i.e., it works the opposite of SSRIs and similar to tianeptine/Stablon).A dose-dependent reuptake enhancement.
If you do a Pubmed search on "egb 761" you'll find over 500 hits. I am not negative about the use of ginkgo. It is "good medicine". It is the Western trend to isolate one characteristic of the herb that disturbs me. Herbs are "many drugs", all at the same time.
Lar
Posted by linkadge on June 3, 2006, at 1:34:50
In reply to Re: Ginkgo increase serotonin uptake » Questionmark, posted by Larry Hoover on May 30, 2006, at 9:23:05
The interesting thing is that tianeptine is not a very strong serotonin uptake acellerator. SSRI's may inhibit SERT like >%70, but comparitively Tianeptine is a weaker serotonin acellerator (in the 20-40% range if I recall)
So, if you found a dose of ginkgo that provided this degree of uptake acelleration, you may not be way off in comparison to tianeptine.
The acetylcholinesterase inhibition of ginkgo, may not be desired though.
Linkadge
Posted by Larry Hoover on June 6, 2006, at 6:38:43
In reply to Re: Ginkgo increase serotonin uptake » Larry Hoover, posted by linkadge on June 3, 2006, at 1:34:50
> The interesting thing is that tianeptine is not a very strong serotonin uptake acellerator. SSRI's may inhibit SERT like >%70, but comparitively Tianeptine is a weaker serotonin acellerator (in the 20-40% range if I recall)
>
> So, if you found a dose of ginkgo that provided this degree of uptake acelleration, you may not be way off in comparison to tianeptine.
>
> The acetylcholinesterase inhibition of ginkgo, may not be desired though.
>
> LinkadgeI wish you could tweak those parameters a bit. Wine varies with the grape. I have no doubt, so does the ginkgo.
Lar
Posted by linkadge on June 26, 2006, at 19:27:26
In reply to Re: Ginkgo increase serotonin uptake » linkadge, posted by Larry Hoover on June 6, 2006, at 6:38:43
I suppose you could try gingko with anticholinergic like cogentin. Perhaps thats getting a little too messy though.
Linkadge
Posted by Franz on October 10, 2006, at 14:36:14
In reply to Re: Ginkgo increase serotonin uptake » Larry Hoover, posted by linkadge on June 3, 2006, at 1:34:50
> The interesting thing is that tianeptine is not a very strong serotonin uptake acellerator. SSRI's may inhibit SERT like >%70, but comparitively Tianeptine is a weaker serotonin acellerator (in the 20-40% range if I recall)
>
> So, if you found a dose of ginkgo that provided this degree of uptake acelleration, you may not be way off in comparison to tianeptine.
>
> The acetylcholinesterase inhibition of ginkgo, may not be desired though.
>
> Linkadge
Damn cholinergic!.I was starting to get interested in ginkgo, also for the supposed alpha brain waves which seem to help in depression/anxiety.
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