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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by verne on February 25, 2006, at 8:29:46
http://store.yahoo.com/iherb/tryptozen.html
It looks like this has the milk protein peptide found in Pro Calm.
Is there anything like Pro Calm at iherb.com ?
Verne
Posted by nolvas on February 25, 2006, at 9:04:32
In reply to Tryptozen, posted by verne on February 25, 2006, at 8:29:46
I've searched iherb and found nothing :(
Pro calm and dolisos seriane are the only ones I know of. They do contain the studied peptides but again I don't know if the formulas are effective.
Heres a couple of studies I found, I don't have the text for the first study, but you get an idea from the title.
STUDY 1 > FASEB J. 2001 Aug;15(10):1780-2.
Characterization of alpha-casozepine, a tryptic peptide from bovine alpha(s1)-casein with benzodiazepine-like activity.STUDY 2 > Eur J Nutr. 2005 Mar;44(2):128-32. Epub 2004 Nov 2.
Effects of a tryptic hydrolysate from bovine milk alphaS1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations.
Messaoudi M, Lefranc-Millot C, Desor D, Demagny B, Bourdon L.
ETAP-Applied Ethology 13, rue du Bois de la Champelle, 54500, Vandoeuvre-les-Nancy, France. etap@etap-lab.com
BACKGROUND: Preclinical results in rats have demonstrated anxiolytic-like effects of a tryptic bovine alphaS1-casein hydrolysate. AIM OF THE STUDY: We investigated the putative effects of this tryptic hydrolysate on systolic (SBP), diastolic (DBP) blood pressures, heart rate (HR) values and plasma cortisol concentrations (CC) in human healthy volunteers facing successive stress situations. METHODS: The subjects were (double blind) randomly allocated to ingest three times, 12 hours apart, two capsules containing either 200 mg of alphaS1-casein hydrolysate (TS) or bovine skimmed milk powder as a placebo (CS). On the morning of the test day, a first blood sample for baseline measurement of CC was taken before the subjects were submitted to the Stroop test (ST) and, after a 30-min rest, to a Cold Pressor test (CPT). SBP, DBP, and HR were continuously recorded for 5 min before the ST and during each stress situation. A second blood sample was taken 15 min after the end of the CPT condition. RESULTS: ST and ST + CPT combined test situations increased SBP, DBP and HR. The significant "Treatment x SBP" and "Treatment x DBP" interactions indicated the lower percentage changes in SBP and DBP of the TS. In addition, the results showed a significant decrease of the CC in the TS but not in the CS throughout the ST + CPT combined stress tests. HR remained stable in TS between the initial rest period and the CPT unlike what happened in CS. CONCLUSION: On the basis of blood pressure and cortisol changes, these results suggest an antistress profile of this alphaS1-casein hydrolysate in human subjects.
Here's a link on anxiolytic compounds which has a link to Milk Protein Hydrolysatehttp://www.netriceuticals.com/articles.asp?id=16
and
http://www.netriceuticals.com/ingredients.asp?id=303
and they sell Pro Calm >
http://www.netriceuticals.com/listing.asp?id=503
Posted by nolvas on February 25, 2006, at 9:32:53
In reply to Re: Tryptozen, posted by nolvas on February 25, 2006, at 9:04:32
Just remembered another link
Lactium >
http://www.nutraingredients-usa.com/news-by-product/indexbyCpyEntry.asp?id=2740&k=lactium
Also this >
Whey protein is a mixture of some of the proteins naturally found in milk. The major proteins found in whey protein include beta-lactoglobulin and alpha-lactalbumin. Whey protein has one of the highest protein digestibility-corrected amino acid scores (PDCAAS; a measure of protein bioavailability) and is more rapidly digested than other proteins, such as casein (another milk protein). 1
Alpha-lactalbumin is a whey protein high in the amino acid tryptophan, which the body uses to make the neurotransmitter serotonin. A double-blind study found that supplementing the diet with alpha-lactalbumin helped improve scores on a memory test in people who were vulnerable to experiencing problems with stress.2 The researchers speculated that the alpha-lactalbumin raised brain serotonin levels in these subjects, which may have improved their tolerance to stress.
So it seems milk proteins have serotonin raising, and benzodiazepine type activity depending on the milk protein.
Milk Protein hydrolysate
(Each serving contains 2.5 mg of αSI casein decapeptide has benzodiazepine type activity in studiesAlpha-lactalbumin raises Serotonin levels according to studies.
It seems Milk Proteins are very interesting anxiolytic compounds.
Posted by nolvas on February 25, 2006, at 18:23:23
In reply to Re: Tryptozen, posted by nolvas on February 25, 2006, at 9:32:53
Sorry for third consecutive post in this thread but I've realised I didn't look at tryptozen. This stuff is very similar to using a casein peptide Dolisos Seriane and Pro Calm it is the milk protein hydrolysate that was tested in studies.
So yeah it seems to be the right stuff. 150mg was the tested dosage and Tryptozen seems to be the only product that has more at 167mg, but I think lipids account for the extra amount quoted.
This is the end of the thread.
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