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Dr. Bob is Robert Hsiung, MD,
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Posted by RedSoxFan79 on December 16, 2005, at 0:16:16
Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial.
Smeraldi E, Benedetti F, Barbini B, Campori E, Colombo C.
Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy.
Total sleep deprivation (TSD) shows powerful but transient clinical effects in patients affected by bipolar depression. Pindolol blocks the serotonergic 5-HT1A autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. We evaluated the interaction of TSD and pindolol in the treatment of acute episodes of bipolar depression. Forty bipolar depressed inpatients were randomized to receive pindolol 7.5 mg/day or placebo for nine days in combination with three consecutive TSD cycles. Pindolol significantly improved the antidepressant effect of TSD, and prevented the short-term relapse after treatment. The response rate (HDRS scores < 8) at the end of treatment was 15/20 for pindolol, and 3/20 for placebo. Coadministration of pindolol and TSD resulted in a complete response, which could be sustained for six months with lithium salts alone, in 65% of cases. This results suggest a major role for serotonergic transmission in the mechanism of action of TSD, and makes TSD treatment more effective in the treatment of bipolar depression.
Posted by linkadge on December 16, 2005, at 20:08:27
In reply to Total sleep deprivation + Pindolol, posted by RedSoxFan79 on December 16, 2005, at 0:16:16
I have heard of lithium carbonate being used in a similar way. Pindolol blocks 5-ht1a autorceptors, and lithium blocks the 5-h1b autoreceptors.
I wonder what sort of effect the combination of lithium and pindolol might be.
Linkadge
Posted by linkadge on December 24, 2005, at 21:49:55
In reply to Re: Total sleep deprivation + Pindolol, posted by linkadge on December 16, 2005, at 20:08:27
Went through a course of sleep deprivation a few days ago. For me, the night of, is generally a very disagreeable experience.
My mood lifts about 5 in the morning, and is good for the rest of the day.
Kind of a sleepy antianxiety effect, but there is a richness to the world that morning, kind of a beautiful otherworldly feeling.
I have noticed that it generally survives one night of sleep, but rarely two.
It seems to have the strongest effect on my sence of worth. It is impossable for me to feel worthless.
Sleep deprivation doesn't have a purely serotonergic effect. I remember reading that it slows the metabolism of all three biogeneic amines.
Linkadge
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