Psycho-Babble Alternative Thread 577825

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what is the precursor to BDNF

Posted by linkadge on November 11, 2005, at 17:42:16

What sorts of nutrients does your body need to synthesize BDNF ?

Linkadge

Re: what is the precursor to BDNF

Posted by nolvas on November 11, 2005, at 22:13:27

In reply to what is the precursor to BDNF, posted by linkadge on November 11, 2005, at 17:42:16

The following may facilitate, stimulate or increase production of BDNF. Studies provided below as well.

Hormones

Estradiol may facilitate the production of BDNF. references

Minerals

Lithium may increase the production of BDNF.

Zinc may increase the production of BDNF.
Pharmaceutical Drugs

Memantine may increase the production of BDNF.

Smart Drugs

Deprenyl may stimulate the production of BDNF.

Hydergine may stimulate the release of BDNF.

Dubal, D. B., et al. Estradiol: a protective and trophic factor in the brain. Alzheimer’s Disease Review. 4:1-9, 1999.

Several studies suggest that estradiol may exert growth promoting effects by influencing the expression of brain-
derived neurotrophic factor.

· Singh, M. The effect of overiectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology. 136(5):2320-2324, 1995.

When the ovaries of female rats were removed (ovariectomized) in order to suppress the endogenous production of estradiol, lowered brain-derived neurotrophic factor (BDNF) occurred.

Hashimoto, R., et al. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology. 43(7):1173-1179, 2002.

Nowak, G., et al. Zinc treatment induces cortical brain-derived neurotrophic factor gene expression. Eur J Pharmacol. 492(1):57-59, 2004.

Marvanova, M., et al. The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Mol Cell Neurosci. 18(3):247-258, 2001.

Mizuta, I., et al. Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes. Biochem Biophys Res Commun. 279(3):751-755, 2000.

Pearson, D., et al. Enriched environment may reduce apoptosis in the brain. The Durk Pearson & Sandy Shaw Life Extension News. 2(4), 1999.

Re: what is the precursor to BDNF

Posted by RedSoxFan79 on November 12, 2005, at 9:40:14

In reply to Re: what is the precursor to BDNF, posted by nolvas on November 11, 2005, at 22:13:27

You failed to mention the most powerful stimulant of BDNF; exercise. I know you asked about precursors and I didnt see any but exercise has proven effects on BDNF.

Re: what is the precursor to BDNF

Posted by linkadge on November 12, 2005, at 16:16:19

In reply to Re: what is the precursor to BDNF, posted by RedSoxFan79 on November 12, 2005, at 9:40:14

Yes I exercise all the time, but I was trying to think about it in a different way.

I read somewhere that exercise induced BDNF expression may be dependant on estrogen.

Interesting to note that exercise can lower zinc levels, so supplementation might be wise.

Linkadge

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