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Dr. Bob is Robert Hsiung, MD,
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Posted by Robert Fairburn on November 25, 2003, at 16:53:44
Lar
have you any knowledge about what particular neurotrphin peptide is responsible for the growth of receptors
Regards Robert
Posted by NoMotic on November 25, 2003, at 21:14:04
In reply to Lar have you any knowledge about BDNF, posted by Robert Fairburn on November 25, 2003, at 16:53:44
There's a good chance you already know about what I'll say, but I'll add what I can to the topic of BDNF just in case someone out there doesn't know. I believe that all antidepressants increase BDNF, which is in part responsible for the growth of brain cells in certain key regions like the hippocampus and prefrontal cortex after 4 weeks or so of antidepressant therapy. I guess one of the theories is that serotonin or norepinephrine enhancement is kind of like a fertilizer for brain cells, and that directly modulating BDNF, rather than indirectly through standard antidepressants, is a new area of research. As I understand, stress and cortisol all lower BDNF, and this may be how cell loss occurs when humans and animals are under stress, and the depressed brain simply may be in a state of reduced cell growth due to too many toxic factors rather than in a state of growth. Increasing BDNF theoretically will override the stress induced cell loss, and BDNF "agonists", if you will, have been working in certain pre-clinical setting tests for depression, as I recall. I believe that therapies that encourage cell growth and lower stress hormone induced cell death is a very important area for future research. BDNF promoters seem to make perfect sense.
Posted by Larry Hoover on November 27, 2003, at 9:15:30
In reply to Lar have you any knowledge about BDNF, posted by Robert Fairburn on November 25, 2003, at 16:53:44
Yes....
The easiest way to increase BDNF is to exercise.
> have you any knowledge about what particular neurotrphin peptide is responsible for the growth of receptors
>
> Regards RobertReceptor synthesis is a complexly regulated phenomenon. There are membrane-linked regualators, RNA-linked regulators (many of those), DNA-linked regulators, chaperone effects...
maybe if you asked a more specific question....
Lar
This is the end of the thread.
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