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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 21 of 21. This is the beginning of the thread.
Posted by mogger on February 13, 2021, at 21:41:24
I am surprised I havent seen more posts regarding ketamine. Specifically I have had four infusions and can definitively say after the fourth treatment my depression was twice as bad if not more than when I started. I can only surmise that added glutamate is not what I need. An awful experience for me but of course I hope others the opposite.
Posted by Lamdage22 on February 14, 2021, at 4:26:49
In reply to Ketamine infusion, posted by mogger on February 13, 2021, at 21:41:24
I have never heard that, but I too sometimes get worse by things that are supposed to make people better. I refrain from Ketamine because I am vulnerable for psychosis.
Posted by mogger on February 14, 2021, at 10:45:52
In reply to Re: Ketamine infusion, posted by Lamdage22 on February 14, 2021, at 4:26:49
I am shocked too as I thought it would be a guaranteed ticket to feeling better. So frustrating.
Posted by beckett2 on February 14, 2021, at 16:58:41
In reply to Ketamine infusion, posted by mogger on February 13, 2021, at 21:41:24
Ketamine doesn't increase or enhance glutamate, does it? I thought it was the opposite.
Posted by beckett2 on February 14, 2021, at 16:59:29
In reply to Ketamine infusion, posted by mogger on February 13, 2021, at 21:41:24
> I am surprised I havent seen more posts regarding ketamine. Specifically I have had four infusions and can definitively say after the fourth treatment my depression was twice as bad if not more than when I started. I can only surmise that added glutamate is not what I need. An awful experience for me but of course I hope others the opposite.
Btw, I'm sorry you had this outcome :(
Posted by mogger on February 14, 2021, at 18:16:36
In reply to Re: Ketamine infusion » mogger, posted by beckett2 on February 14, 2021, at 16:58:41
It increases glutamate big time but is also an nmda antagonist.
Posted by beckett2 on February 14, 2021, at 18:20:51
In reply to Re: Ketamine infusion » beckett2, posted by mogger on February 14, 2021, at 18:16:36
> It increases glutamate big time but is also an nmda antagonist.
So weird (and interesting) bc I thought (obviously incorrectly) that excess glutamate is implicated in chronic pain (which I have) and I did very well w a transfusion, which helped my mood and my pain level.
So now you know it does not work for you. Have you tried a medication that affects glutamate in an 'opposite' way? Maybe through a psychopharmacologist.
Posted by Lamdage22 on February 15, 2021, at 0:08:02
In reply to Re: Ketamine infusion » Lamdage22, posted by mogger on February 14, 2021, at 10:45:52
When I was in hospital, they claimed that 70% respond.
> I am shocked too as I thought it would be a guaranteed ticket to feeling better. So frustrating.
Posted by mogger on February 15, 2021, at 8:21:14
In reply to Re: Ketamine infusion, posted by Lamdage22 on February 15, 2021, at 0:08:02
I am a true non responder in every sense!
Posted by Lamdage22 on February 15, 2021, at 8:31:51
In reply to Re: Ketamine infusion » Lamdage22, posted by mogger on February 15, 2021, at 8:21:14
Well, it was a negative response. I hate those. I always ask myself if i wil return back to my old normal or if the negative changes will stick.
> I am a true non responder in every sense!
Posted by linkadge on February 15, 2021, at 9:26:36
In reply to Re: Ketamine infusion » mogger, posted by beckett2 on February 14, 2021, at 16:58:41
>Ketamine doesn't increase or enhance glutamate, >does it? I thought it was the opposite.
The actions are complex (some enhancement and some inhibition).
Linkadge
Posted by mogger on February 15, 2021, at 14:56:38
In reply to Re: Ketamine infusion, posted by linkadge on February 15, 2021, at 9:26:36
Felt like enhancement and I dont do well with glutamate
Posted by undopaminergic on February 16, 2021, at 2:39:28
In reply to Re: Ketamine infusion » linkadge, posted by mogger on February 15, 2021, at 14:56:38
> Felt like enhancement and I dont do well with glutamate
How did you know what enhancement feels like?
-undopaminergic
Posted by alchemy on February 16, 2021, at 21:14:42
In reply to Re: Ketamine infusion » Lamdage22, posted by mogger on February 15, 2021, at 8:21:14
> I am a true non responder in every sense!
me too :( sorry for your struggle. glad i'm not alone.
i just tried a week of microdosing and i think it made me worse.
i've explored all avenues.
Posted by mogger on February 16, 2021, at 21:50:47
In reply to Re: Ketamine infusion, posted by undopaminergic on February 16, 2021, at 2:39:28
Its like a wired too bright rush of depression and anxiety that comes in waves. Totally the opposite of relaxed and uplifting.
Posted by mogger on February 16, 2021, at 21:53:15
In reply to Re: Ketamine infusion » mogger, posted by alchemy on February 16, 2021, at 21:14:42
I did microdosing too and it was awful. Made me worse. So sorry about your situation.
Posted by undopaminergic on February 17, 2021, at 3:20:52
In reply to Re: Ketamine infusion » undopaminergic, posted by mogger on February 16, 2021, at 21:50:47
> Its like a wired too bright rush of depression and anxiety that comes in waves. Totally the opposite of relaxed and uplifting.
>Yes, but how do you know it has to do with excess glutamate?
-undopaminergic
Posted by mogger on February 17, 2021, at 8:09:05
In reply to Re: Ketamine infusion, posted by undopaminergic on February 17, 2021, at 3:20:52
Identical feeling when I took high dose of glutamine.
Posted by Patrick35660 on February 23, 2021, at 22:14:02
In reply to Ketamine infusion, posted by mogger on February 13, 2021, at 21:41:24
Ketamine infusions didnt work well for me either after 6 months. I did really well for those 6 months (I thought) after taking an initial 12 infusions with 2 boosters. I crashed and took 9 more infusions hoping to get back to where I was for those 6 months and my anxiety and depression are worse now than they were before I took the treatments. I wish the best for you - the clinic I went to didnt mention anything about previous bouts with psychosis on my intake forms that I remember but Ive seen articles since I took the treatments that say it can make psychosis worse and I was diagnosed with a psychotic break in 2001. Spent a whole lot of money to get worse!
Posted by mogger on February 23, 2021, at 23:15:51
In reply to Re: Ketamine infusion, posted by Patrick35660 on February 23, 2021, at 22:14:02
I am so sorry to hear this what a nightmare. It certainly aggravated my situation a huge amount. I cut off after four as I was heading down hill quickly. The fourth treatments disassociation was awful. I believe it will wear off for you in time. Hang in there.
Posted by Lamdage22 on February 24, 2021, at 5:33:34
In reply to Re: Ketamine infusion, posted by Patrick35660 on February 23, 2021, at 22:14:02
!!!! Thanks for sharing here. It is important to do so!
>and my anxiety and depression are worse now than they were before I took the treatments. I wish the best for you - the clinic I went to didnt mention anything about previous bouts with psychosis on my intake forms that I remember but Ive seen articles since I took the treatments that say it can make psychosis worse and I was diagnosed with a psychotic break in 2001. Spent a whole lot of money to get worse!
This is the end of the thread.
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