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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by linkadge on July 14, 2018, at 9:00:00
Has anybody else used this stuff. Technically, it is a supplement (related to arginine), but supposedly has rapid acting antidepressant effects, with a mechanism similar to ketamine.
I bought some (very cheap) and have been trying it out.
Linkadge
Posted by Lamdage22 on July 14, 2018, at 9:05:36
In reply to Agmatine, posted by linkadge on July 14, 2018, at 9:00:00
How did it go?
Posted by linkadge on July 14, 2018, at 9:43:47
In reply to Re: Agmatine, posted by Lamdage22 on July 14, 2018, at 9:05:36
I took 500mg. There was definitely an effect in a short period of time.
I will post follow ups. The medical cannabis is still helping (more so with somatic symptoms / insomnia). I have had depression creep back more recently. I have effexor, but wanted to try something else first.Linkadge
Posted by Lamdage22 on July 14, 2018, at 9:53:43
In reply to Re: Agmatine, posted by linkadge on July 14, 2018, at 9:43:47
I cant do this because i have some sort of schizo disorder.
Posted by sigismund on July 14, 2018, at 15:41:32
In reply to Agmatine, posted by linkadge on July 14, 2018, at 9:00:00
Worked immediately it seemed to me, and caused cold sores straight away too.
NAD+ precursors (NMN) did the same but not as quickly.
I liked both of them and would like to be able to take them.
Posted by linkadge on July 15, 2018, at 17:28:03
In reply to Re: Agmatine, posted by sigismund on July 14, 2018, at 15:41:32
Yes, agmatine does work immediately! I noticed an effect within about 20-30 min of taking.
Cold sores? Is there a mechanism for that? I have noticed no side effects whatsoever.
I'm very happy about findings this - cheap - and seems to have a positive effect.
Linkadge
Posted by sigismund on July 16, 2018, at 15:05:05
In reply to Re: Agmatine, posted by linkadge on July 15, 2018, at 17:28:03
I don't know why. A bit like arginine and ornithone?
I was especially disappointed by NMN doing that to me. I retried it and the same thing happened.
Posted by linkadge on July 16, 2018, at 17:16:57
In reply to Re: Agmatine, posted by sigismund on July 16, 2018, at 15:05:05
Strange. I'll keep an eye out for that.
The AD effect is very quick. However, I don't necessarily think it is a long lasting (i.e. days / weeks aka ketamine).
I seem to notice a dropoff after about 24 hours. But, its definately an antidepression effect (not like a stimulant).Seems to be agreeeing with me. Keep my fingers crossed.
Linkadge
Posted by beckett2 on July 17, 2018, at 8:59:03
In reply to Re: Agmatine, posted by linkadge on July 14, 2018, at 9:43:47
> I took 500mg. There was definitely an effect in a short period of time.
>
>
> I will post follow ups. The medical cannabis is still helping (more so with somatic symptoms / insomnia). I have had depression creep back more recently. I have effexor, but wanted to try something else first.
>
> Linkadge
>If taken daily, would this work like a regular antidepressant, creating a sustained (24 hour) effect?
Posted by linkadge on July 17, 2018, at 12:00:08
In reply to Re: Agmatine » linkadge, posted by beckett2 on July 17, 2018, at 8:59:03
>If taken daily, would this work like a regular
>antidepressant, creating a sustained (24 hour)
>effect?Not entirely sure. We'll see how it goes.
Linkadge
Posted by Mogger on July 22, 2018, at 23:17:20
In reply to Agmatine, posted by linkadge on July 14, 2018, at 9:00:00
Caused wicked depression for me. Used it for OCD for glutamate modulating properties. Same with Sarcosine.
Posted by linkadge on July 26, 2018, at 16:18:35
In reply to Re: Agmatine, posted by Mogger on July 22, 2018, at 23:17:20
Strange.
I used it a few times and haven't used it since (generally depression free for a few weeks) but not sure if it was due to the agmatine. I often have spontaneous remissions.
Linkadge
Posted by mogger on July 27, 2018, at 16:04:47
In reply to Re: Agmatine, posted by linkadge on July 26, 2018, at 16:18:35
There arent many supplements that work for me other than vitamin d, NAC and inositol. How is the CBD going?
Posted by linkadge on July 28, 2018, at 15:43:29
In reply to Re: Agmatine » linkadge, posted by mogger on July 27, 2018, at 16:04:47
There is still a benefit from the CBD. It's effect seems pretty broad spectrum.
However, the cost is a bit high, so I can't take as much as I likely benefit from.
Linkadge
Posted by TriedEveryMedication on July 3, 2022, at 21:54:30
In reply to Agmatine, posted by linkadge on July 14, 2018, at 9:00:00
Anyone else try this for depression?
I see some chatter about it on reddit - ranging from it is the greatest thing to it makes depression worse
This is the end of the thread.
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