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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Lamdage22 on November 1, 2016, at 11:43:47
Hey Scott,
i have seen you changed from abilify to brexpiprazole! How is the tardive dyskinesia, tardive akathisia and tardive dementia risk compared to my meds?
I sure could use the "less weight gain" aspect of brexpiprazole and some antidepressant effects wouldnt hurt either. What are you thinking?
THX
Posted by Lamdage22 on November 1, 2016, at 11:49:52
In reply to Brexpiprazole, posted by Lamdage22 on November 1, 2016, at 11:43:47
does it keep you awake at night?
Posted by SLS on November 1, 2016, at 15:57:35
In reply to Brexpiprazole, posted by Lamdage22 on November 1, 2016, at 11:43:47
> Hey Scott,
>
> i have seen you changed from abilify to brexpiprazole! How is the tardive dyskinesia, tardive akathisia and tardive dementia risk compared to my meds?
>
> I sure could use the "less weight gain" aspect of brexpiprazole and some antidepressant effects wouldnt hurt either. What are you thinking?
>
> THXHi Lamdage.
I switched from Abilify 10 mg/day to Rexulti 2.0 mg/day. I experience a more robust antidepressant effect now. Abilify left me somewhat flat. Rexulti has given me increased mental energy and motivation.
I'm sure you know that brexpiprazole (Rexulti) and aripiprazole (Abilify) are chemical cousins. They are very similar pharmacologically. However, brexpiprazole has a lower dopamine D3/D2 receptor binding ratio. The lower ratio should translate to a reduced risk of akathisia. My guess is that movement side effects are lower with both drugs when compared to most other antipsychotics. I base this guess on the fact that both drugs are DA receptor partial agonists (rather than full antagonists).
I am not convinced that brexpiprazole has a reduced risk of weight-gain relative to aripiprazole. Although my doctor has not seen weight gain with brexpiprazole, I am not losing any weight since switching between them. My appetite is not different. I am trying to change my eating habits a bit, so we'll see how that goes.
- Scott
Posted by SLS on November 1, 2016, at 16:03:10
In reply to Re: Brexpiprazole, posted by Lamdage22 on November 1, 2016, at 11:49:52
> does it keep you awake at night?
No. I've been taking Rexulti for about 6 weeks. At no time have I experienced sleep disturbances. Abilify didn't bother me either.
- Scott
This is the end of the thread.
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