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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by rjlockhart37 on October 24, 2016, at 21:51:05
i've noticed the older generation meds, antidepressants, anti-psychotics, are defeintly strong but there harsh in their side effects.....parnate definetly is effective antidepressant, and i've read many posts here it's ability to relive depression along with Nardil and Marplan
but also the old generation anti-psychotics are strong, but their side effect profile i think is why the pharma companies have made newer ones that have less side effects......i've met 2 people who took thorazine and said it made their life and anxity better, i was in summer school in 05 and i noticed how smart he was in writing papers, and doing assingments, but he slept so much, and always told me he was going to take a nap when he got home, he told me he took Orap (pimozide), orap is a strong antipsychtotic and should not be messed with because of it's direct effects in blocking dopamine. Funny thing i was on large amounts of adderall, and he out did me in assignments, while he was taking a strong dopamine blocker, and was always sleepy, adderall increases dopamine makes you alert.....never understood that.....maybe too much dopamine makes you over think things
but also stelazine (trifluoperazine) i've read people on babble it's antianxiety effect was very good, no paranoia.....it seems like some of these older generation ones are very effective but they just are harsh in more side effects, just like MAOI's are so effective in treating depression, but they have signifant side effects.....
anyone notice that?
Posted by David1973 on October 25, 2016, at 16:20:57
In reply to older generation meds, posted by rjlockhart37 on October 24, 2016, at 21:51:05
I've been very lucky so it seems. Nearly 3 years on 75mg nardil and I haven't had one side effect.
Posted by rjlockhart37 on October 27, 2016, at 22:03:49
In reply to Re: older generation meds, posted by David1973 on October 25, 2016, at 16:20:57
nardil is very strong, and effective
but alot of the older anti-psychosis meds, like the old ones that made people shuffle and jerk, i think that's why they did away with those and came up with zyprexa and newer ones.....alot of the old ones made you jerk, and have movement disorders similar to Parkinson's disease....but still there effective but during the periods of the 1940's-1980's where the old generation anti-psychotics, im sure in all the hospitals there where alot of side effect with movement disorders
Posted by Zyprexa on October 28, 2016, at 22:29:24
In reply to Re: older generation meds, posted by rjlockhart37 on October 27, 2016, at 22:03:49
well, I took abilify for 6 months and it gave me really bad TD, shaky hands, so I couldn't solder at work. Later on I went of abilify and took perphenazine for 8 years and no where near the side effects of abilify. I now get the ocassional jerk but that is not often. the TD from abilify never totaly went away. I still can't solder very well with out shaky hands. But I don't think its as bad now.
Posted by Christ_empowered on October 29, 2016, at 9:00:10
In reply to Re: older generation meds, posted by Zyprexa on October 28, 2016, at 22:29:24
I had to take Haldol orally in a hospital. Akathisia, plus no concentration. I don't know how people take that stuff, or why its still somewhat popular...aren't there other older APs out there?
Abilify gets the job done for me. 30mgs/day, so that's a fairly big dose. I'm glad that Abilify and now the baby Abilifies are on the market. I got bad akathisia off zyprexa and seroquel, even though I was already on a full dose Klonopin. Not good. The D2 partial agonism makes it possible for me to take a therapeutic dose of a neuroleptic.
Posted by Zyprexa on October 31, 2016, at 8:37:04
In reply to Re: older generation meds, posted by Christ_empowered on October 29, 2016, at 9:00:10
perphenazine is from the same generation. It works pretty good. for some reason APs that are sedating seem to work best for me.
but ADs that are sedating don't, like remeron.
i always had a theory that seroquel would work for me. but i never tried it. because it would make me fat too.
i tried abilify and geodon. but both were bad. I guess they were not heavely sedating enough. Plus they just made me psychotic. risperdal too. On those three I had holucinations, voices and inability to function. But zyprexa, perphenazine, CBD, all worked.
Posted by Christ_empowered on October 31, 2016, at 10:54:23
In reply to Re: older generation meds » Christ_empowered, posted by Zyprexa on October 31, 2016, at 8:37:04
if you have significant agitation, anxiety, insomnia, etc., then lower potency, more sedating antipsychotics make a lot of sense. Zyprexa and perphenazine are, I think, more mid-potency. Seroquel and Thorazine are low-potency, which means fewer EPS, usually less tardive dyskinia over the long haul (unless its high dosed, of course), but (obviously) more sedation, sleeping too much, concentration problems.
Thorazine is notorious for sometimes causing depression. For me, Seroquel did the same thing, and I was irritable. Plus, I got weird twitches, especially at night, from seroquel, and nightmares. Not good.
Abilify does the heavy lifting in my combination. The Trileptal and Lamictal help with lingering mood problems and more than likely help calm me down, without causing signficant sedation. I take a lot (400mgs) of the 2x daily version of Wellbutrin, which seems to help with concentration, mood, and countering some of the sedation from the other medications.
Everybody is different. Bio-psycho-social differences=different responses to drugs, different needs, etc.
I hope your treatments continue helping you.
Posted by rjlockhart37 on November 1, 2016, at 1:15:42
In reply to Re: older generation meds, posted by Christ_empowered on October 29, 2016, at 9:00:10
there's tons of older antipychotics....ill google some of them, but they mainly where used from 1940's-to the 80s......then in the 90s when newer generation ones came into play
yea there's tons of them.....kinda like there forgotten about
Posted by rjlockhart37 on November 1, 2016, at 1:19:05
In reply to Re: older generation meds » Christ_empowered, posted by rjlockhart37 on November 1, 2016, at 1:15:42
https://en.wikipedia.org/wiki/List_of_antipsychotics
http://www.goodtherapy.org/drugs/anti-psychotics.html
http://psychopharmacologyinstitute.com/antipsychotics/first-generation-antipsychotics/typical antipychosis meds are the old ones
Posted by Lamdage22 on November 5, 2016, at 9:13:39
In reply to Re: older generation meds, posted by Christ_empowered on October 29, 2016, at 9:00:10
I got bad akathisia off zyprexa and seroquel,
And fine on abilify? I am just the opposite.
Posted by rjlockhart37 on November 5, 2016, at 23:39:27
In reply to Re: older generation meds, posted by Lamdage22 on November 5, 2016, at 9:13:39
the older ones had more extrapyramdal side effects, and there more serious than new gnereation ones, there effective but harsh, and have sometimes disabling side effects. It depends on the person, but i've read the older ones made you jerk, have movement disorders, you pace back and forth (restless, can't be content with staying still) because it blocks dopamine, similar to Parkinson's disease, and also cognitive dulling alot more than new ones like zyprexa .... zyprexa is sedating but it's effective for types of psychotic depression
but here's some info on the old generation antipsychotics (typical)
https://en.wikipedia.org/wiki/Extrapyramidal_symptoms
https://en.wikipedia.org/wiki/Typical_antipsychotic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004713/
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