Shown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Prefect on October 26, 2016, at 20:05:55
I've read grapefruit juice can affect the absorption of Luvox. But what about limes and lemons, which I consume almost everyday in my salad/sparkling water? I take 100 mg of Luvox/day
Posted by rjlockhart37 on October 26, 2016, at 23:40:48
In reply to Lime 'n' Luvox, posted by Prefect on October 26, 2016, at 20:05:55
that's the same thing with xanax, i used to drink grapefruit juice with xanax and it boosted it's effect, but in a way it was wierd, it was not like more of it, it had a wierd effect on my if took xanax with grapefruit juice, it's not healthy really do it, the effect was not euphoric, it just increased the sedation
but lime and lemon i think don't have the chemical that grapefruit juice has in it, but still you could give it a try, but try small amounts
Posted by SLS on October 27, 2016, at 6:50:34
In reply to Lime 'n' Luvox, posted by Prefect on October 26, 2016, at 20:05:55
> I've read grapefruit juice can affect the absorption of Luvox. But what about limes and lemons, which I consume almost everyday in my salad/sparkling water? I take 100 mg of Luvox/day
It's not absorption that is acting on Luvox here. It is a reduction of metabolism in the liver that occurs after absorption that creates the higher levels of Luvox. After absorption from the digestive tract, Luvox is carried in the blood to the liver. In the liver, the furanocoumarin contained in grapefruits slows things down for Luvox metabolism by inhibiting an enzyme know as CYP3A4. Sweet oranges and lemons don't have appreciable amounts of furanocoumarins in them, and would not react with Luvox. In general, limes have low levels of furanocoumarindo, but I don't know for sure to what extent it affects Luvox levels.
Sorry I couldn't have been more help.
- Scott
Posted by Phillipa on October 27, 2016, at 9:30:55
In reply to Re: Lime 'n' Luvox, posted by SLS on October 27, 2016, at 6:50:34
Drink tons of green tea and have to add lots of pure lemon juice to it as no taste otherwise. Take only 25mg of luvox but been doing same for years. Don't notice a thing. Phillipa
Posted by Lamdage22 on October 27, 2016, at 12:39:58
In reply to Re: Lime 'n' Luvox, posted by Phillipa on October 27, 2016, at 9:30:55
The reaction with grapefruit is pretty nasty. Been there done that.
Posted by Prefect on October 27, 2016, at 18:25:02
In reply to Re: Lime 'n' Luvox, posted by SLS on October 27, 2016, at 6:50:34
Holly crap check out these links! It looks like limes are almost as bad as grapefruit?...Or am I reading this wrong? So if they slow down the Luvox metabolism, does that increase or decrease its positive effects? I eat an insane amount of limes!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641707/figure/pone.0142757.g002/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641707/figure/pone.0142757.g003/
Posted by Phillipa on October 27, 2016, at 18:42:24
In reply to Re: Lime 'n' Luvox, posted by Prefect on October 27, 2016, at 18:25:02
Says coumadin? Where is the name luvox?
Posted by Prefect on October 27, 2016, at 19:29:09
In reply to Re: Lime 'n' Luvox » Prefect, posted by Phillipa on October 27, 2016, at 18:42:24
I doesn't mention Luvox, I'm talking about the ingredient in limes that causes the same effect as grapefruit
Posted by Phillipa on October 27, 2016, at 20:08:44
In reply to Re: Lime 'n' Luvox, posted by Prefect on October 27, 2016, at 19:29:09
Oh that makes sense then. Thanks
Posted by Prefect on October 28, 2016, at 19:27:09
In reply to Re: Lime 'n' Luvox, posted by SLS on October 27, 2016, at 6:50:34
Scott, does it mean it would increase the effect of the drug or decrease it?
Posted by SLS on October 28, 2016, at 21:49:18
In reply to Re: Lime 'n' Luvox » SLS, posted by Prefect on October 28, 2016, at 19:27:09
> Scott, does it mean it would increase the effect of the drug or decrease it?
Grapefruit juice will cause the blood levels of certain drugs to increase. It is important to understand that these drugs are not made more effective or less effective. There is simply more of it flowing through the blood stream because less of it is being metabolized and eliminated.
Grapefruit juice will cause the blood levels of Luvox to increase unpredictably. It will not make Luvox work any better. In order to best manage the dosage of Luvox, it is better to not consume grapefruit.
- Scott
This is the end of the thread.
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