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Posted by porkpiehat on December 11, 2015, at 13:01:53
In reply to ADs and hostility, posted by Lamdage22 on December 11, 2015, at 11:19:22
> I think i may get on a combination of St Johns Wort, Cannabidiol and Lithium Orotate.
>
> Perhaps a little Metformin for lifestyle purposes.
>
> Things that will certainly not make me hostile. Almost every antidepressant makes me hostile or anxious or both.
Adrenergics make me both nervous and hostile. I see you're taking effexor and buspar (both did this to me)...Are you able to narrow it down to a particular pathway?
>
Posted by Lamdage22 on December 11, 2015, at 13:04:50
In reply to Re: ADs and hostility » Lamdage22, posted by porkpiehat on December 11, 2015, at 13:01:53
Not really a specific pathway.
Mirtazapine, Effexor, Brintellix, Nardil, Parnate...
There may be others i forgot.
Posted by SLS on December 11, 2015, at 13:10:39
In reply to ADs and hostility, posted by Lamdage22 on December 11, 2015, at 11:19:22
Hello, Lamdage.
> I think i may get on a combination of St Johns Wort, Cannabidiol and Lithium Orotate.
>
> Perhaps a little Metformin for lifestyle purposes.
>
> Things that will certainly not make me hostile. Almost every antidepressant makes me hostile or anxious or both.
>Let's see how hostile you can get at me.
Diagnosis: schizo-affective, type depressive
Your current regime:
Seroquel 700mg
Zyprexa 12.5mgThese drugs suck when it comes to weight gain and diabetes. How did you discover that you absolutely need both of them? I would consider dropping one or both of them and trying Saphris (asenapine). It shouldn't increase anxiety or produce akathisia.
Effexor 75 mgYou might get hostile from serotonin reuptake inhibitors. If this is true, you would have to discontinue the Effexor. I wouldn't do that right away, though. I would push the dosage gradually to 300 mg/day. 75 mg/day is *usually* far too little. Try it now and get it over with.
Metformin 2000mgIf you switch to Saphris, you would not need metformin. Metformin is not without side effects, as I'm sure you are aware. Besides, I think it tends to lose its effects over time.
Buspar 5mgIf this drug is not having the desired effect, discontinue it.
Lithium orotate 360mgI would try lithium carbonate 300 mg/day for 1 - 2 weeks with the option to increase the dosage. If you don't like it, you can always switch back. Lithium carbonate is well studied and has been proven effective since 1947. The 300 mg/day is primarily for depression. Higher dosages are used for bipolar disorder *and* schizophrenia.
Some Vitamin DThis is barely worth taking unless you go with 50,000 IU.
Are you pissed off yet?
- Scott
Posted by SLS on December 11, 2015, at 13:14:29
In reply to Re: ADs and hostility » Lamdage22, posted by porkpiehat on December 11, 2015, at 13:01:53
> > I think i may get on a combination of St Johns Wort, Cannabidiol and Lithium Orotate.
> >
> > Perhaps a little Metformin for lifestyle purposes.
> >
> > Things that will certainly not make me hostile. Almost every antidepressant makes me hostile or anxious or both.
>
>
> Adrenergics make me both nervous and hostile. I see you're taking effexor and buspar (both did this to me)...Are you able to narrow it down to a particular pathway?Buspar becomes 1-PP in the body after it is metabolized. 1-PP acts exactly like the noredrenergic property of Remeron - NE alpha2 antagonism. Drugs that do this make me feel worse and produce anxiety.
- Scott
Posted by Lamdage22 on December 11, 2015, at 13:19:38
In reply to Re: ADs and hostility, posted by SLS on December 11, 2015, at 13:10:39
Why would i be? Effexor makes me anxious (psychotic) at higher dosages. I am currently on "Pascoe neurapas balance". (St Johns Wort) This is the only thing that has ever worked, that has not changed me in any negative way.
Its day 2 or 3 and i feel good. I even went lower with the Effexor (half 37.5 mg pill) with no ill effects. Before, i would be suicidal as sh*t so i think the neurapas is working.
I take Vitamin D only to maintain the recommended blood level.
Buspar made me wake up later and thats a NO-NO for me.
Saphris didnt make it through german trials for schizophrenia. It is only approved for Mania over here.
"I would try lithium carbonate 300 mg/day for 1 - 2 weeks with the option to increase the dosage. If you don't like it, you can always switch back. Lithium carbonate is well studied and has been proven effective since 1947. The 300 mg/day is primarily for depression. Higher dosages are used for bipolar disorder *and* schizophrenia."
Will do, but first i want to be a bit lower with the Seroquel and Zyprexa so i dont get any extra weight gain.
"Seroquel 700mg
Zyprexa 12.5mgThese drugs suck when it comes to weight gain and diabetes. How did you discover that you absolutely need both of them?"
I didnt discover that, i was forced and now my body kind of seems to demand it.
Posted by Lamdage22 on December 11, 2015, at 13:22:19
In reply to Re: ADs and hostility, posted by Lamdage22 on December 11, 2015, at 13:19:38
Oh and i forgot to tell: I had palpitations on 600 and 900mg Lithium.
Are you mad at me now?
Posted by Lamdage22 on December 11, 2015, at 13:23:52
In reply to Re: ADs and hostility » porkpiehat, posted by SLS on December 11, 2015, at 13:14:29
> Buspar becomes 1-PP in the body after it is metabolized. 1-PP acts exactly like the noredrenergic property of Remeron - NE alpha2 antagonism. Drugs that do this make me feel worse and produce anxiety.
>
>
> - ScottPretty impressive what you know about this stuff.
Posted by Lamdage22 on December 11, 2015, at 15:22:42
In reply to Re: ADs and hostility, posted by Lamdage22 on December 11, 2015, at 13:23:52
maybe you should double check your vitamin d recommendation??
Posted by SLS on December 11, 2015, at 19:53:10
In reply to Re: ADs and hostility, posted by Lamdage22 on December 11, 2015, at 13:19:38
Hi, Lamdage.
You know yourself well. I guess potent SRI drugs (SSRI, SNRI) screw you up. Sorry.
Saphris is an interesting drug. A friend of mine had been on Navane (thiothixeine), an older AP, to control her more extreme delusions and psychoses. However, everything didn't come together for her until she added Saphris. It almost instantly cleared up her thinking and produced an energizing antidepressant effect. She has schizoaffective disorder (bipolar type), and is now in complete remission.
Keep trying. Whenever you doubt that drug therapy is worthwhile, remember the times, no matter how brief, when treatment made you feel unquestionably better.
- Scott
Posted by SLS on December 11, 2015, at 19:56:43
In reply to Re: ADs and hostility, posted by Lamdage22 on December 11, 2015, at 13:22:19
> Oh and i forgot to tell: I had palpitations on 600 and 900mg Lithium.
>
> Are you mad at me now?No.
I am mad at your illness.
You have been a perfect gentleman.
- Scott
Posted by SLS on December 11, 2015, at 20:03:42
In reply to Re: ADs and hostility, posted by Lamdage22 on December 11, 2015, at 15:22:42
> maybe you should double check your vitamin d recommendation??
Yes. My mistake. Thank you.
I meant to say 50,000 IU of D3 per week. It can be taken all at once as one dose, preferably with a meal that includes some fat. I take 35,000 IU per week. I might increase it.
- Scott
Posted by rjlockhart37 on December 11, 2015, at 21:12:26
In reply to ADs and hostility, posted by Lamdage22 on December 11, 2015, at 11:19:22
it depends on the anti-depressant, but mainly reason there causing to walk on egg shells is because they elevate serotonin and dopamine, depending on one.......
you may ask about Lithium Carbonate, (the presciption) it's much stronger than orotate form, and maybe adding it will produce equilibrium in the nuerotransmitters
Lithium is an old, and one the most effective medication's for the mood. Ask your doctor, another suggestion, there's 2 things online, adrafinil which is another version of provogil but it has hefty sie effects, but it may help with depression, that and stablon which you can order, there not controlled substnaces that i know of and they look like they could give a benefit without addiction, or serious side effects
Posted by Lamdage22 on December 12, 2015, at 3:11:10
In reply to Re: ADs and hostility, posted by rjlockhart37 on December 11, 2015, at 21:12:26
Made me anxious, hostile or paranoid:
Parnate, Nardil, Moclobemide, Effexor, Remeron
Made me suicidal:
Brintellix
Posted by Lamdage22 on December 12, 2015, at 8:35:34
In reply to Re: ADs and hostility, posted by Lamdage22 on December 12, 2015, at 3:11:10
i have updated my signature so there is no confusion.
St johns wort seemed to be pro-anxious/psychotic as well so i have cut the dosage down from 6 pills (highest recommended dosage) to two pills today.
I feel OK. Hope i can replace Effexor completely. Even if st johns wort didnt work better, it has the advantage of having no sexual side effects!
@Scott: My blood level of vitamin d3 was "37". What is a good target blood level? Last year the doctor had me take 40.000 iu weekly. I didnt have any winter blues whereas this year i totally have winter blues.
Posted by Christ_empowered on December 12, 2015, at 12:03:02
In reply to Re: ADs and hostility, posted by Lamdage22 on December 12, 2015, at 8:35:34
You're kind of on a lot of tranquilizers...sedating ones, at that, but...have you ever tried Surmontil? I think the generic is trimipramine. I would think that or amoxapine or even just adding some prozac (since you're on zyprexa already) might be good options.
Just a suggestion.
Posted by Lamdage22 on December 12, 2015, at 12:36:44
In reply to Re: ADs and hostility, posted by Christ_empowered on December 12, 2015, at 12:03:02
> You're kind of on a lot of tranquilizers...sedating ones, at that, but...
CE, i know but reducing them is a slow process, not something to do overnight. Once the doctors found it necessary to dose it so high. (Even higher than now).
have you ever tried Surmontil? I think the generic is trimipramine. I would think that or amoxapine or even just adding some prozac (since you're on zyprexa already) might be good options.
>
> Just a suggestion.Thanks but no more crazy pharmaceuticals... i am happy with what i have now.
Posted by Lamdage22 on December 12, 2015, at 13:13:50
In reply to Re: ADs and hostility, posted by Lamdage22 on December 12, 2015, at 12:36:44
This is my new signature. I will reduce the APs when its time.
I may take cannabidiol next year and drop Seroquel, Zyprexa and Metformin if i find it safe.
Posted by Lamdage22 on December 12, 2015, at 13:14:26
In reply to Re: ADs and hostility, posted by Lamdage22 on December 12, 2015, at 13:13:50
And i will also ditch Venlafaxine.
Posted by Lamdage22 on December 14, 2015, at 22:01:42
In reply to Re: ADs and hostility, posted by Lamdage22 on December 12, 2015, at 13:14:26
Hey yáll,
So i ditched Venlafaxine and i take 60mg of dry SJW extact. Its extremely low (otherwise i cant sleep without a horse tranquilizer), but it seems to be working better than Venlafaxine was.
I seem to have a more pronounced reaction to meds than "regular" people.
Now i am trying to make doctors read this: http://www.medicinalgenomics.com/wp-content/uploads/2013/01/Bergamaschi_2011.pdf
and tell me if Cannabidiol is advisable or not. My appointment with the cannabinoid doc is in April 2016.Cheers
Julian
Posted by SLS on December 14, 2015, at 22:31:02
In reply to Successfully weined off Venlafaxine with SJW, posted by Lamdage22 on December 14, 2015, at 22:01:42
> Hey yáll,
>
> So i ditched Venlafaxine and i take 60mg of dry SJW extact. Its extremely low (otherwise i cant sleep without a horse tranquilizer), but it seems to be working better than Venlafaxine was.Do you think the SJW made it easier to discontinue the Effexor?
> Now i am trying to make doctors read this: http://www.medicinalgenomics.com/wp-content/uploads/2013/01/Bergamaschi_2011.pdf
Thanks for the link.
- Scott
Posted by Lamdage22 on December 14, 2015, at 23:54:18
In reply to Re: Successfully weined off Venlafaxine with SJW, posted by SLS on December 14, 2015, at 22:31:02
> Do you think the SJW made it easier to discontinue the Effexor?
Absolutely. I was suicidal the last time i tried to stop Effexor. Now im not.
Its weird huh? That prescription SSRI have all these sexual side effects and SJW does not although it also has SSRI action. SSRI is seemingly not always the same.
Posted by Lamdage22 on December 15, 2015, at 0:03:32
In reply to Re: Successfully weined off Venlafaxine with SJW, posted by Lamdage22 on December 14, 2015, at 23:54:18
SJW is a blessing. I was up and awake today since 4!! 30! in the AM.
Motivation for goal directed activity raised a great deal.
Higher dosage would be even better. Have to ask pdoc.
Posted by SLS on December 15, 2015, at 6:41:29
In reply to Re: Successfully weined off Venlafaxine with SJW, posted by Lamdage22 on December 14, 2015, at 23:54:18
> > Do you think the SJW made it easier to discontinue the Effexor?
>
> Absolutely. I was suicidal the last time i tried to stop Effexor. Now im not.That's fascinating.
> Its weird huh? That prescription SSRI have all these sexual side effects and SJW does not although it also has SSRI action. SSRI is seemingly not always the same.
I don' think they know everything that SJW does on a biological level. Which constituent do you feel is most important? Hypericin? Hyperforin? Other?
https://en.wikipedia.org/wiki/Hypericum_perforatum#Mechanism_of_action
- Scott
Posted by Lamdage22 on December 15, 2015, at 6:53:24
In reply to Re: Successfully weined off Venlafaxine with SJW, posted by SLS on December 15, 2015, at 6:41:29
from what i have read hyperforin. Its a GABA/Glutamate/Dopamine-Norepinephrine-Serotonin reuptake inhibitor!
Posted by Lamdage22 on January 7, 2016, at 11:12:57
In reply to Re: Successfully weined off Venlafaxine with SJW, posted by Lamdage22 on December 15, 2015, at 6:53:24
Well like most things for depression these days, SJW made me pre-psychotic so i had to discontinue. Back to Venlafaxine.
This is the end of the thread.
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