![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by paulb on November 27, 2015, at 12:32:18
hi
i wanted to ask if anyone knew if tiagabine, a gaba re-uptake inhibitor is selective for GABAA or GABAB or both. reason im asking is would it augment a benzo which are gaba a selective. any references to books or pages on the web that support your answer would be helpful
kind vregards
paulb
Posted by linkadge on November 27, 2015, at 17:11:24
In reply to is tiagabine gaba-a or b selective, posted by paulb on November 27, 2015, at 12:32:18
Tiagabine is a gaba reuptake inhibitor. Thus is will increase gaba at all gaba receptor subtypes.
Linkadge
Posted by linkadge on November 27, 2015, at 17:15:07
In reply to is tiagabine gaba-a or b selective, posted by paulb on November 27, 2015, at 12:32:18
Have you ever tried phenbut?
Linkadge
Posted by paulb on November 27, 2015, at 18:07:29
In reply to Re: is tiagabine gaba-a or b selective, posted by linkadge on November 27, 2015, at 17:15:07
I havent tried phenibut but i have tried picamilon which is a similar nootropic. I dont really believe in natural supplements for great effect unless they are taken in higher than recommeneded doses but thats just my opinion. I really appreciate the information you passed on regardiung tiagabine but what was the source. is it a page on the net or in a book. could you provide a link or a book that details this information because it was my understanding that tiagabine was selective for GAT1 which must mean it is selective for certain subtypoes of GABA receptor. BYW have you bried it. is it like a benzo or more llike pregabalin.
good to hear from you cheers paulb
Posted by linkadge on November 28, 2015, at 8:06:13
In reply to Re: is tiagabine gaba-a or b selective, posted by paulb on November 27, 2015, at 18:07:29
Hi,
For tiagabine, I just looked on Wikipedia.
As for supplements. I have tried many. Phenibut is very good comparatively. It has primary actions on calcium channels (chemically related to gabapentin) and gaba-b receptors. Actually, it was just discovered this year, that phenebut is active and stronger on calcium channels than gaba-b.
Linkadge
Posted by paulb on November 28, 2015, at 8:27:03
In reply to Re: is tiagabine gaba-a or b selective, posted by linkadge on November 28, 2015, at 8:06:13
phenibut work probably work well with gabapentin or npregabalin as for it blocking calcium cannels that could help as a mood stabiliser
Posted by phidippus on December 4, 2015, at 0:24:33
In reply to is tiagabine gaba-a or b selective, posted by paulb on November 27, 2015, at 12:32:18
both
eric
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.