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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by Thomas4779 on October 2, 2015, at 13:32:13
I have been on Luvox since 2008. At first it worked remarkably well. Stopped my panic and helped my depression significantly. However around 2011 i started to have a return of symptoms. I tried to go up to the max of 300mg but sexual dysfunction kicked in also extreme fatigue and lower back pain. Since then I have tried adding different drugs to help the Luvox kick back in. Nothing has really helped yet. My doctor is really pushing to add seroquel to the mix. But I have taken that prior to Luvox in the past and it made me feel like a zombie. So i talked him in to giving me a script for imipramine. Hoping that i could eventually cross taper on to the imipramine. I am looking to have the antipanic and antidepressant effects of a drug without the sexual dysfunction. Any thoughts? I am currently on 200mg of Luvox and 25mg imipramine. Already noticed it helped my back pain
Posted by phidippus on October 16, 2015, at 0:15:34
In reply to From Luvox to imipramine, posted by Thomas4779 on October 2, 2015, at 13:32:13
>So i talked him in to giving me a script for imipramine. Hoping that i could eventually cross taper on to the imipramine. I am looking to have the antipanic and antidepressant effects of a drug without the sexual dysfunction. Any thoughts? I am currently on 200mg of Luvox and 25mg imipramine. Already noticed it helped my back pain
my thoughts are that you are switching from an SSRI that's been FDA approved for OCD to a TCA, Imipramine, which is considered one of the most effective antidepressants ever made.
Imipramine is very strong reuptake inhibition. Imipramine has the second highest attraction for the serotonin transporter (SERT) in the tricyclic antidepressant class behind clomipramine. This provides a very strong and proportional effect on the blockade of serotonin reuptake. Moderating this effect, however, is imipramine's continual conversion in the body to its metabolite desipramine, which has extremely strong and relatively selective noradrenergic effects. This blend of imipramine and desipramine circulating together within the body provides a powerful one-two punch in simultaneously blockading both serotonin and norepinephrine reuptake.
BUT, this comes at a price. Imipramine is antiholergenic, so you get all the side effects associated with...such as: dizziness, drowsiness, confusion, seizures, headache, anxiety, tremors, stimulation, weakness, insomnia, nightmares, extrapyramidal symptoms in geriatric patients, increased psychiatric symptoms, paresthesia, orthostatic hypotension, ECG changes,tachycardia, hypertension, palpitations, dysrhythmias, blurred vision, tinnitus, mydriasis, dry mouth, nausea, vomiting, paralytic ileus, increased appetite, cramps, epigastric distress, jaundice, hepatitis, stomatitis, constipation, taste change, urinary retention, agranulocytosis, thrombocytopenia, eosinophilia, leukopenia, rash, urticaria, diaphoresis, pruritus, photosensitivity
I know the list is long...Just know that you're probably going to experience more side effects.
Imipramine is a great tool for battling depression and anxiety associated with depression.
Eric
This is the end of the thread.
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