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Dr. Bob is Robert Hsiung, MD,
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Posted by rjlockhart37 on August 22, 2015, at 0:18:09
http://jpet.aspetjournals.org/content/335/2/401.full
i noticed this......i got on google and looked this up, for some reason when i vape, or smoke, or anything with nicotine the pleasure from nicotine is reduced from lamotragine.......i noticed it would block it's effect....not totally but significant part which makes nicotine pleasurable.....
Posted by SLS on August 22, 2015, at 5:53:22
In reply to lamotragine blocking nicotinic actions, posted by rjlockhart37 on August 22, 2015, at 0:18:09
Nice work.
"...[blocks] human α4β2-nAChRs [nicotinic acetylcholine receptors] heterologously expressed in the SH-EP1 cell line and on native α4β2-nAChRs in dopaminergic (DA) neurons in rat ventral tegmental area (VTA)."
This would pretty much explain your reduced sense of pleasure when smoking while taking lamotrigine (Lamictal).
- Scott
Posted by rjlockhart37 on August 22, 2015, at 12:00:20
In reply to Re: lamotragine blocking nicotinic actions » rjlockhart37, posted by SLS on August 22, 2015, at 5:53:22
it does......i noticed it even before i looked it up on google......maybe it can be a off label smoking aid medication lol
r
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