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Dr. Bob is Robert Hsiung, MD,
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Posted by phidippus on March 13, 2015, at 13:27:56
J Clin Psychiatry. 2006 Nov;67(11):1735-40.
Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder.
Moreno FA1, Wiegand CB, Taitano EK, Delgado PL.
Author information
Abstract
BACKGROUND:Anecdotal reports suggest that psychedelic agents may relieve symptoms of obsessive-compulsive disorder (OCD). This modified double-blind study investigated the safety, tolerability, and clinical effects of psilocybin, a potent 5-HT(1A) and 5-HT(2A/2C) agonist, in patients with OCD.
METHOD:Nine subjects with DSM-IV-defined OCD and no other current major psychiatric disorder participated in up to 4 single-dose exposures to psilocybin in doses ranging from sub-hallucinogenic to frankly hallucinogenic. Low (100 microg/kg), medium (200 microg/kg), and high (300 microg/kg) doses were assigned in that order, and a very low dose (25 microg/kg) was inserted randomly and in double-blind fashion at any time after the first dose. Testing days were separated by at least 1 week. Each session was conducted over an 8-hour period in a controlled environment in an outpatient clinic; subjects were then transferred to a psychiatric inpatient unit for overnight observation. The Yale-Brown Obsessive Compulsive Scale (YBOCS) and a visual analog scale measuring overall obsessive-compulsive symptom severity were administered at 0, 4, 8, and 24 hours post-ingestion. The Hallucinogen Rating Scale was administered at 8 hours, and vital signs were recorded at 0, 1, 4, 8, and 24 hours after ingestion. The study was conducted from November 2001 to November 2004.
RESULTS:Nine subjects were administered a total of 29 psilocybin doses. One subject experienced transient hypertension without relation to anxiety or somatic symptoms, but no other significant adverse effects were observed. Marked decreases in OCD symptoms of variable degrees were observed in all subjects during 1 or more of the testing sessions (23%-100% decrease in YBOCS score). Repeated-measures analysis of variance for all YBOCS values revealed a significant main effect of time on Wilks lambda (F = 9.86, df = 3,3; p = .046), but no significant effect of dose (F = 2.25, df = 3,3; p = .261) or interaction of time and dose (F = 0.923, df = 9,45; p = .515). Improvement generally lasted past the 24-hour timepoint.
CONCLUSIONS:In a controlled clinical environment, psilocybin was safely used in subjects with OCD and was associated with acute reductions in core OCD symptoms in several subjects.
Posted by Bill82 on March 13, 2015, at 19:37:02
In reply to psilocybin for OCD, posted by phidippus on March 13, 2015, at 13:27:56
Many people before this study have reported similar findings on an individual basis. The theorized key to psylocibins effect is it's overload of the 5ht2a receptor(which pure seritonin or other objects can't replicate because of seritonin syndrom) which causes a dramatic rather than slow downregulation of 5ht2a receptors. This ultimately causes an anti ocd and antidepressant response that can last a while. Personal reports suggest it can last for a few weeks. Problems arise however in that those who are predisposed to psychosis can have their symptoms present at the time of administration, and the possibility of post halucinigen perception disorder, which is seemingly benign but can bother a lot of people, potentially adding to long term stress. Sadly, higher doses(much higher than this study) have been reported to have better effects, meaning a more intense trip. People have had success with low dose administration daily(as you quickly become immune to hallucinatory effects) but anecdotal reports state this causes similar effects as an ssri(impotence, insomnia). Psychologically, people also report high doses provide their effect due to ego death that can occur, meaning the user perceives the entire universe from a inhumanly unbiased view point seeing everything as is. This can render the user to see their obsession as is, potentially putting it to rest, almost in a manner as instantaneous(but very intense) exposure and response prevention therapy. As a sufferer of rather bad and extreme ocd I have often thought of trying shrooms, but the lack true scientific studies on psylocibin has honestly made me hesitant, and reluctant to pull the trigger so to speak, and personally I advise anyone who wants to attempt this to take caution and use common sense. Also make sure to identify the right mushroom haha, some can kill
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