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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Michael Bell on November 3, 2009, at 21:10:13
Has anyone noticed that playing around with certain neurotransmitters makes them more humorous (appreciate jokes more, tell more jokes, etc.)? Picamilon had this effect on me. I've heard others say Aricept, which affects acetylcholine. And many people say Adderall and other stims take away their creativity and sense of humor. Any feedback on this?
Posted by jparsell82 on December 1, 2009, at 21:31:05
In reply to neurotransmitters and humor, posted by Michael Bell on November 3, 2009, at 21:10:13
A little late but yes definitely. I've noticed that stimulants kill most of my sense of humor unfortunately. It's very frustrating. You've heard that Aricept affects humor positively or negatively?? I have some laying around... I assumed it would make you less humorous and possibly depressed being that it affects acetylcholine.
Any other ideas on what I could augment a stimulant with to get my sense of humor back?
Posted by Sigismund on December 4, 2009, at 1:30:40
In reply to Re: neurotransmitters and humor, posted by jparsell82 on December 1, 2009, at 21:31:05
Stimulants would, and hallucinogens and cannabis wouldn't, which should be a clue.
Posted by maria3667 on February 9, 2015, at 11:32:12
In reply to neurotransmitters and humor, posted by Michael Bell on November 3, 2009, at 21:10:13
Yes, I noticed a profound increase in humor with Remeron (mirtazipine). Also made me much more sociable & sexual... If only the downside - horrendous weightgain - wasn't so strong!
Maria
> Has anyone noticed that playing around with certain neurotransmitters makes them more humorous (appreciate jokes more, tell more jokes, etc.)? Picamilon had this effect on me. I've heard others say Aricept, which affects acetylcholine. And many people say Adderall and other stims take away their creativity and sense of humor. Any feedback on this?
Posted by Louisiana Sportsman on February 9, 2015, at 12:21:04
In reply to Re: neurotransmitters and humor, posted by maria3667 on February 9, 2015, at 11:32:12
> Yes, I noticed a profound increase in humor with Remeron (mirtazipine). Also made me much more sociable & sexual... If only the downside - horrendous weightgain - wasn't so strong!
>
> MariaMaria, I have noticed this effect with mirtazapine 45mg. QHS. You hit the nail on the head; the weight gain is so bad off that I have an appointment with a consultant at The Wellness Center about how to mitigate the weight gain caused by mirtazapine (dietary changes, supplements, exercises, etc.) so I can manage my weight while continuing mirtazapine therapy. I've gained 50lbs. and I was in shape before Remeron. I hope that the life coach approach can allow me to lose weight and keep taking it, I really like mirtazapine now that the H1 antagonism no longer causes daytime sedation, only at night when I need it. It's the most effective antidepressant I take.
Posted by maria3667 on February 9, 2015, at 15:23:53
In reply to Re: neurotransmitters and humor, posted by Louisiana Sportsman on February 9, 2015, at 12:21:04
Hi Louisiana,
Wow, what a swift reply to such an old thread (2009)!
In the end I did find a way to stop the weight gain on Remeron by taking it together with an anti-acid medication called Ranitidine (Zantac/Pepcid). But I remember it was expensive to get to the required effective dose. I took 150mg of Ranitidine before bedtime & 150mg in the morning. That stopped the weight gain & munchies... or vice versa :) ..... But I couldn't get the gained pounds off... So in the end I quit the Remeron.
Too bad you gained so much weight, I know how you feel!
Hopefully together with the above info and your the Wellness Center you're more successful at it than I was.
Good luck!
Maria
> > Yes, I noticed a profound increase in humor with Remeron (mirtazipine). Also made me much more sociable & sexual... If only the downside - horrendous weightgain - wasn't so strong!
> >
> > Maria
>
> Maria, I have noticed this effect with mirtazapine 45mg. QHS. You hit the nail on the head; the weight gain is so bad off that I have an appointment with a consultant at The Wellness Center about how to mitigate the weight gain caused by mirtazapine (dietary changes, supplements, exercises, etc.) so I can manage my weight while continuing mirtazapine therapy. I've gained 50lbs. and I was in shape before Remeron. I hope that the life coach approach can allow me to lose weight and keep taking it, I really like mirtazapine now that the H1 antagonism no longer causes daytime sedation, only at night when I need it. It's the most effective antidepressant I take.
>
Posted by Lamdage22 on February 16, 2015, at 3:51:19
In reply to Re: neurotransmitters and humor, posted by maria3667 on February 9, 2015, at 11:32:12
You could try Metformin or Liraglutide for weight maintenance.
Antidiabetics.
Posted by Maria3667 on March 6, 2015, at 5:13:05
In reply to Re: neurotransmitters and humor, posted by Lamdage22 on February 16, 2015, at 3:51:19
Hi Lamdage,
I tried the Metformine before, but it causes severe dry mouth for me. I'm afflicted with Sjogren's syndrome and thus dry mouth is already a problem (causing painful gum sores, root canal problems, etc.).
Liraglutide side effects also mention 'dry mouth'.
Thanks for trying to find a solution though!
Maria
Posted by Lamdage22 on March 7, 2015, at 4:16:14
In reply to Re: neurotransmitters and humor, posted by Maria3667 on March 6, 2015, at 5:13:05
And liraglutide may not be as safe as metformin.
Posted by Maria3667 on May 22, 2015, at 10:46:10
In reply to Re: neurotransmitters and humor, posted by Lamdage22 on March 7, 2015, at 4:16:14
True!
That being said, has anyone found any medication / supplement to increase humor???
Sheesh!! It's so desperately needed in this crazed up world... News headlines making me more depressed & I work in media....
Maria
> And liraglutide may not be as safe as metformin.
This is the end of the thread.
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