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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Lamdage22 on July 19, 2014, at 13:07:42
They keep coming with orodispersible Lorazepam and Zyprexa.
Is there any scientific evidence that these two meds go through mucosa into the blood stream??
These annoy me. I want a regular tablet that you swallow.
Posted by Christ_empowered on July 19, 2014, at 14:40:05
In reply to Any scientific evidence for orodispersible tabs?, posted by Lamdage22 on July 19, 2014, at 13:07:42
they probably just wanna make some money by bringing back Ativan in dissolving form. might hit quicker.
ODT zyprexa might cause fewer metabolic issues. or not.
Posted by Lamdage22 on July 20, 2014, at 9:41:35
In reply to Re: Any scientific evidence for orodispersible tabs?, posted by Christ_empowered on July 19, 2014, at 14:40:05
Might.
There might also be wasted medication.
Posted by ed_uk2010 on July 21, 2014, at 14:01:37
In reply to Any scientific evidence for orodispersible tabs?, posted by Lamdage22 on July 19, 2014, at 13:07:42
> They keep coming with orodispersible Lorazepam and Zyprexa.
>
> Is there any scientific evidence that these two meds go through mucosa into the blood stream??Lorazepam and olanzapine (Zyprexa) are predominantly absorbed through the gastrointestinal tract, not the oral mucosa. The idea that these two particular meds have a more rapid onset of action when allowed to dissolve in the mouth is a myth. Standard tablets dissolve rapidly in the stomach and are absorbed from the intestine.
Orodispersible olanzapine tablets have two main uses:
1. They are used in inpatient psychiatry for patients with 'compliance issues' eg. spitting tablets out and hiding them.
2. They are useful for those with swallowing difficulties.
Some brands of standard lorazepam tablets dissolve fairly quickly in the mouth and are almost tasteless.
Orodispersible tabs can safety be swallowed whole if you swallow them straight away. Is it not necessary to allow them to disperse... although they normally do so rapidly.
It has been claimed that orodispersible olanzapine causes less weight gain. I find this highly unconvincing. The studies require replication.
Manufacturers are keen to bring out orodispersible tablets mainly as a way of increasing profits via maintenance of market share + charging higher prices.
Posted by Lamdage22 on July 22, 2014, at 9:41:27
In reply to Re: Any scientific evidence for orodispersible tabs?, posted by ed_uk2010 on July 21, 2014, at 14:01:37
I knew it. It sounds like BS to me that they go through oral mucosa. Yet still employees and nurses talk this BS about letting it dissolve in the mouth and that it "hits in 20 seconds".
How come such ignorance. I thought they are all scientific and what not.
> > They keep coming with orodispersible Lorazepam and Zyprexa.
> >
> > Is there any scientific evidence that these two meds go through mucosa into the blood stream??
>
> Lorazepam and olanzapine (Zyprexa) are predominantly absorbed through the gastrointestinal tract, not the oral mucosa. The idea that these two particular meds have a more rapid onset of action when allowed to dissolve in the mouth is a myth. Standard tablets dissolve rapidly in the stomach and are absorbed from the intestine.
>
> Orodispersible olanzapine tablets have two main uses:
>
> 1. They are used in inpatient psychiatry for patients with 'compliance issues' eg. spitting tablets out and hiding them.
>
> 2. They are useful for those with swallowing difficulties.
>
> Some brands of standard lorazepam tablets dissolve fairly quickly in the mouth and are almost tasteless.
>
> Orodispersible tabs can safety be swallowed whole if you swallow them straight away. Is it not necessary to allow them to disperse... although they normally do so rapidly.
>
> It has been claimed that orodispersible olanzapine causes less weight gain. I find this highly unconvincing. The studies require replication.
>
> Manufacturers are keen to bring out orodispersible tablets mainly as a way of increasing profits via maintenance of market share + charging higher prices.
Posted by Zyprexa on July 22, 2014, at 23:42:01
In reply to Re: Any scientific evidence for orodispersible tabs?, posted by ed_uk2010 on July 21, 2014, at 14:01:37
I found that splitting the dose of zyprexa to 2 times a day, makes weight loss easier. I take 10mg at 10pm and the other 5mg at 4am. I had lower appetite and lost a few pounds by the next day. When I took it all at 10pm, I was more hungry during the night and had gained a few pounds over 2 weeks, 5 to be exact.
This is the end of the thread.
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