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Dr. Bob is Robert Hsiung, MD,
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Posted by europerep on June 8, 2014, at 14:09:23
In reply to CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 8, 2014, at 13:21:22
There are surely studies being done, but since a few months ago, CBD is also available in Germany on prescription. So you could have much easier access to it that way, if that's what you (and your doc) would like to try.
Posted by vbs on June 8, 2014, at 15:11:47
In reply to CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 8, 2014, at 13:21:22
Good luck. And interesting study. I enjoy marijuana but it can make my psychotic symptoms worse. I'd like to try CBD. Thanks for sharing.
Posted by Beckett on June 8, 2014, at 15:46:18
In reply to CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 8, 2014, at 13:21:22
Good luck, too. I tried CBD this year, but not for psychotic symptoms but for insomnia. Made me paranoid as heck and stoned (not in a good way) the next day. Here in California every other person has a prescription, and from what I understand, people react individually with no exact way to predict, so you could give it a try and have good results.
By the way, I slept like a log.
Posted by Phillipa on June 8, 2014, at 18:27:26
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Beckett on June 8, 2014, at 15:46:18
Beckett can you buy just this CBD by itself in CA or just the whole MJ? Phillipa
Posted by Beckett on June 9, 2014, at 1:31:14
In reply to Re: CBD cannabidiol very promising for schizophrenia » Beckett, posted by Phillipa on June 8, 2014, at 18:27:26
Yes, I was given a sample of CBD tincture. I think the CBD strain is available to smoke or to vaporize. Not sure how it's all done. The tincture was strong. First night ten drops knocked me out. I dialed it back to about six drops. Still, didn't work for me.
Posted by Lamdage22 on June 9, 2014, at 4:30:56
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Beckett on June 8, 2014, at 15:46:18
It made you paranoid? Its supposed to do the opposite!
Sure that there was no THC in it?
Posted by Lamdage22 on June 9, 2014, at 5:51:36
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 9, 2014, at 4:30:56
Those are the two major studies.
Brazil 2006: Cannabidiol compared to Haldol and Clozapine.
Cannabidiol seemed to have been equally effective.
http://www.scielo.br/pdf/bjmbr/v39n4/6164.pdfGermany, recently. Cannabidiol equally effective as Amisulpride.
http://www.nature.com/tp/journal/v2/n3/full/tp201215a.htmlThis is the Website of Prof. Dr. Markus Leweke from Germany:
https://translate.google.com/translate?hl=de&sl=de&tl=en&u=http%3A%2F%2Ftrip.cimh.de%2Fhtd%2Fforschung.htmlHe is conducting another study for Cannabidiol in Schizophrenia by autumn of this year for longer term Cannabidiol treatment.
Its very interesting.
Posted by Lamdage22 on June 9, 2014, at 8:22:32
In reply to MJ`s Cannabidiol for Schizophrenia Studies links, posted by Lamdage22 on June 9, 2014, at 5:51:36
http://www.leafscience.com/2014/03/18/drug-made-cannabis-treat-schizophrenia/
Can you believe it?
Get psyched, get the word out and support in any way you can.
Posted by Beckett on June 9, 2014, at 14:06:02
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 9, 2014, at 4:30:56
> It made you paranoid? Its supposed to do the opposite!
>
> Sure that there was no THC in it?Weird, huh? The THC content was like 0.1. I used to get super paranoid on cannabis, so I think I'm an anomaly. You might do very well, which would be great. Good luck to you :-)
Posted by Lamdage22 on June 10, 2014, at 4:21:15
In reply to Re: CBD cannabidiol very promising for schizophrenia » Lamdage22, posted by Beckett on June 9, 2014, at 14:06:02
> > It made you paranoid? Its supposed to do the opposite!
> >
> > Sure that there was no THC in it?
>
> Weird, huh? The THC content was like 0.1. I used to get super paranoid on cannabis, so I think I'm an anomaly. You might do very well, which would be great. Good luck to you :-)Me too.. not when i started it but later on. Thats why i thought CBD might help me since it is supposed to do the opposite.
Posted by Lamdage22 on June 10, 2014, at 11:54:46
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 10, 2014, at 4:21:15
I am surprised at how little interest there is for my thread...
Posted by Zyprexa on June 11, 2014, at 0:37:08
In reply to CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 8, 2014, at 13:21:22
I belive it. When I'm off meds, I usualy end up smoking MJ. Usually a version that is lower in THC.
Posted by Lamdage22 on June 11, 2014, at 7:40:18
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Zyprexa on June 11, 2014, at 0:37:08
> I belive it. When I'm off meds, I usualy end up smoking MJ. Usually a version that is lower in THC.
Id never do that.. a psychotic episode is just too painful for everyone involved and even for those that are only indirectly affected. No fun.
Im looking for the cheapest source of CBD possible though. I have contacted an attorney to inform me about Germanys rules and regulations. I hope that way i soon know what i am allowed to do and what not.
Then i can do more research.
Im throwing in those links again with new ones.
NEW
http://psychcentral.com/news/2012/06/07/marijuana-compound-may-beat-antipsychotics-at-treating-schizophrenia/39803.html
http://www.leafscience.com/2014/03/18/drug-made-cannabis-treat-schizophrenia/
http://marijuana.com/news/2014/03/can-cannabidiol-cbd-cure-schizophrenia-gw-pharmaceuticals-says-yes/
OLD
Study in Brazil and Study in Germany
http://www.scielo.br/pdf/bjmbr/v39n4/6164.pdfhttp://www.nature.com/tp/journal/v2/n3/full/tp201215a.htmlEnjoy.
I love that it says it is doing the Opposite of THC. Because when i smoked i always became EXTREMELY self conscious. Maybe this will kick that social anxiety in the butt as well.
I am exited and i hope i can do this both legally and financially.
My father has declared his support first time i told him about it.
Posted by Lamdage22 on June 11, 2014, at 7:43:59
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 11, 2014, at 7:40:18
I forgot this one:
Posted by Zyprexa on June 12, 2014, at 0:45:25
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 11, 2014, at 7:40:18
Whats the difference, I'm already psychotic from being off the meds. Plus it keeps me from going nuts. I would rather the meds.
Posted by Lamdage22 on June 12, 2014, at 11:11:23
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Zyprexa on June 12, 2014, at 0:45:25
> Whats the difference, I'm already psychotic from being off the meds. Plus it keeps me from going nuts. I would rather the meds.
You can always go back to taking them
Posted by Lamdage22 on June 13, 2014, at 5:26:29
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 12, 2014, at 11:11:23
The only thing i am worried about is wether Cannabidiol is very sedating. I may have to use an antidote for that...
Thoughts?
Posted by Zyprexa on June 14, 2014, at 3:42:27
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 12, 2014, at 11:11:23
My doc wanted me to try getting off of meds. I'm back on them now. 2 years I was in a bad state.
Posted by Lamdage22 on June 14, 2014, at 8:24:35
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Zyprexa on June 14, 2014, at 3:42:27
Wow they usually recommend that everybody stays on them.
Posted by Lamdage22 on June 14, 2014, at 8:46:54
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 14, 2014, at 8:24:35
I think CBD sounds amazing.. i have heard that low doses are stimulating and high doses are (innitially) sedating.
That may explain why some got paranoid from a low dose.
And the side effects are stuff like inhibition of cancer cell growth. Thats what i call a good treatment. No diabetes, weight gain and movement disorders!
I found Dr, pharmacy and financial help for CBD treatment. Now i only have to wait until my Psychiatrist from Rehab comes back from his Vacation. Since i am in rehab he needs to be on board as well.
Posted by Lamdage22 on June 14, 2014, at 10:23:11
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 14, 2014, at 8:46:54
http://www.ncbi.nlm.nih.gov/m/pubmed/22083592/
This sounds crappy. Although i am told that animal findings do often not translate into humans.
Posted by Lamdage22 on June 14, 2014, at 11:25:28
In reply to Ok maybe the news is not all positive, posted by Lamdage22 on June 14, 2014, at 10:23:11
RATIONALE: Several pre-clinical and human-based studies have shown that acutely administered cannabidiol (CBD) can produce anxiolytic-like effects
OBJECTIVES: The present study investigated the effects of chronic administration of CBD on rat behaviour and on the expression of brain proteins.
METHODS: Male Lister-hooded rats (150-200 g, n = 8 per group) received daily injections of CBD (10 mg/kg, i.p.) for 14 days. The rats were subjected to two behavioural tests: locomotor activity and conditioned emotional response (CER). The expression of brain-derived neurotrophic factor (BDNF), its receptor tyrosine kinase B (Trk B), extracellular signal-regulated kinases (ERK1/2) and phospho-ERK1/2 and the transcription factor cyclic AMP response element binding protein activation (CREB) and phospho-CREB were determined in brain regions such as the frontal cortex and hippocampus using Western immunoblotting.
RESULTS: CBD significantly increased the time spent freezing in the CER test with no effect on locomotor activity. CBD significantly reduced BDNF expression in the hippocampus and frontal cortex with no change in the striatum. In addition, CBD significantly reduced TrkB expression in the hippocampus with a strong trend towards reduction in the striatum but had no effect in the frontal cortex. In the hippocampus, CBD had no effect on ERK1/2 or phospho-ERK2, but in the frontal cortex, CBD significantly reduced phospho-ERK1/2 expression without affecting total ERK.
CONCLUSION: Chronic administration of CBD produced an anxiogenic-like effect in clear opposition to the acute anxiolytic profile previously reported. In addition, CBD decreased the expression of proteins that have been shown to be enhanced by chronic treatment with antidepressant/anxiolytic drugs.
Posted by Zyprexa on June 16, 2014, at 11:03:18
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 14, 2014, at 8:24:35
Luckly I was not totaly off my meds, just reduced. I told doc it was a bad idea, she was origionly talking about total wash out.I freaked at the idea and managed to just get greatly reduced. I don't know where docs get these crazy ideas from.
Posted by Lamdage22 on June 27, 2014, at 11:14:35
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Zyprexa on June 16, 2014, at 11:03:18
Yeah.. if you do reduce APs you got to take an extremly slow taper. Anything else will throw you back and you end up worse and with more APs than you had in the first place.
Posted by Lamdage22 on July 5, 2014, at 13:42:46
In reply to Re: CBD cannabidiol very promising for schizophrenia, posted by Lamdage22 on June 27, 2014, at 11:14:35
http://files.iowamedicalmarijuana.org/petition/2012/Bergamaschi_2011.pdf
Sorry if anyone got their hopes up, i have to smash them.
Liver metabolism, Cortisone and immune system issues. Potentially.
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Dr. Bob is Robert Hsiung, MD,
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