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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Phillipa on May 13, 2014, at 12:25:13
Was talking to neighbor who is taking pristiq without any side effects. But when she had taken effexor she was wired and went right off it? I thought they basically were the same meds? Why one and not the other? She's not depressed given for what she thought could become depression after a death in her immediate family. Anxiety. Thanks Phillipa
Posted by poser938 on May 13, 2014, at 13:50:16
In reply to Effexor vs Pristiq????, posted by Phillipa on May 13, 2014, at 12:25:13
I never took Pristiq . but Effexor was nothing but hell for me. one of the worst meds I ever took. 75mgs wasn't bad. but 150mgs gave me extreme anxiety. hair loss. Involuntary muscle movements in my face and a weird emotion sensitivity to foods I ate.
and from what I read, Effexor is known for its side effects. maybe that's why they came out with Pristiq. I don't know anything about chemistry, but maybe they found it would be a more tolerable med.
Posted by Beckett on May 13, 2014, at 14:17:08
In reply to Re: Effexor vs Pristiq????, posted by poser938 on May 13, 2014, at 13:50:16
Hi Phillipa,
Are you thinking of trying either? Pristiq had much less side effects. It also helped with spinal pain oddly enough. It is sometimes advertised as helping women with menopausal symptoms. Like effexor, if I forgot my daily dose, I would start to get sick later in the day.
Posted by Phillipa on May 13, 2014, at 21:07:15
In reply to Re: Effexor vs Pristiq????, posted by Beckett on May 13, 2014, at 14:17:08
Beckett no not thinking of taking it. Just surprised to hear of this neighbor taking one with horrible side effects and none on this. Now I wonder of the chemistry differences. Could be the slow release? Phillipa
Posted by Beckett on May 13, 2014, at 22:11:54
In reply to Re: Effexor vs Pristiq???? » Beckett, posted by Phillipa on May 13, 2014, at 21:07:15
I think it's more that pristiq is some metabolite of effexor, though I could imagine that the slow release has some effect on the percieved side effects as well
Posted by LouisianaSportsman on May 13, 2014, at 22:23:37
In reply to Effexor vs Pristiq????, posted by Phillipa on May 13, 2014, at 12:25:13
Generally, with metabolized drugs such as desvenlafaxine (Pristiq)--> Effexor (venlafaxine) or paliperidone (Invega) --> risperidone (Risperdal); also, you have prodrugs such as Vyvanse, oxcarbamazepine (Trileptal) [that removes the epoxide away from the carbazepine for better side effects] or various pain management derivatives; their effects are going to mimic their master medicament and be clinically biased as such.
However, these medicines can be sneaky and alternative effects, some significant and some mild, have been observed from all that differentiate from the master medicament.
Desvenlafaxine is definitely one that once patients start-- they do not handle Effexor well at all. Anecdotal note: both my dad and I took Pristiq (both diagnosed with MDD, he was indicated for Pristiq, responded, and I took it due to indication of a genetic response) and we both decided to taper using Effexor XR-- well, we definitely got the F off of it.
With the changeover from Pristiq to Effexor XR during a titration off of it, I developed anorgasmia from it that I did not have with Pristiq as well as a "blunted effect", if that makes sense.
** disregard MY THEORY! When Pristiq users begin to start taking the Effexor they can only get their CYP2D6 enzymes to get about 3/4 of the venlafaxine converted into Pristiq. The other 1/4 venlafaxine BS, the alternative metabolites, might be causing different effects such as stronger SERT inhibition that cause these differentiated effects. **hypothesis**
She definitely needs to consult with her PDOC ASAP about this.
This is the end of the thread.
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