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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Bob on February 16, 2014, at 14:10:54
I'm starting to lose faith in lurasidone (Latuda). I've been on it for about 6 weeks now and all the uplifting and energizing effects I had on startup are long gone and now it only seems to be producing a slight malaise. About 30-60 minutes after a dose I feel more depressed and tired. I wears off for the most part after that but any benefits seem to be gone. I was looking for an antidepressant/energizing effect but it has not persisted.-Bob
Posted by SLS on February 16, 2014, at 18:49:18
In reply to Lurasidone, posted by Bob on February 16, 2014, at 14:10:54
>
> I'm starting to lose faith in lurasidone (Latuda). I've been on it for about 6 weeks now and all the uplifting and energizing effects I had on startup are long gone and now it only seems to be producing a slight malaise. About 30-60 minutes after a dose I feel more depressed and tired. I wears off for the most part after that but any benefits seem to be gone. I was looking for an antidepressant/energizing effect but it has not persisted.
>
> -BobYou could try cutting back to 20 mg/day. I might do this myself as an experiment. Since the binding affinity of lurasidone for 5-HT7 receptors is higher than it is for NE alpha-2 receptors, I am hoping that at very low dosages, 5-HT7 blockade will occur with little or no NE alpha-2 blockade.
- Scott
Posted by b2chica on March 4, 2014, at 9:14:07
In reply to Lurasidone, posted by Bob on February 16, 2014, at 14:10:54
it seems this is more common that not.
i was hoping to try Latuda since my Insurance company won't cover zyprexa anymore.
but i choose to wait as everyone i've talked with, and even my T said that most folks she knows says everyone she knows that went on it, ended up getting off it, since it stopped working. or just never really worked.i wish you much luck.
Posted by Bob on March 6, 2014, at 13:54:26
In reply to Re: Lurasidone, posted by b2chica on March 4, 2014, at 9:14:07
> it seems this is more common that not.
> i was hoping to try Latuda since my Insurance company won't cover zyprexa anymore.
> but i choose to wait as everyone i've talked with, and even my T said that most folks she knows says everyone she knows that went on it, ended up getting off it, since it stopped working. or just never really worked.
>
> i wish you much luck.
As I look back I have to say that the first few days showed some definite promise. Old interests suddenly were coming back. That pretty much faded.
Posted by b2chica on March 6, 2014, at 14:00:02
In reply to Re: Lurasidone » b2chica, posted by Bob on March 6, 2014, at 13:54:26
Sorry to hear that... Best wishes
Posted by SLS on March 6, 2014, at 14:28:35
In reply to Re: Lurasidone » b2chica, posted by Bob on March 6, 2014, at 13:54:26
> As I look back I have to say that the first few days showed some definite promise. Old interests suddenly were coming back. That pretty much faded.
I'm sorry.
My experience with lurasidone was similar.
- Scott
This is the end of the thread.
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