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Dr. Bob is Robert Hsiung, MD,
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Posted by TriedEveryMedication on October 12, 2013, at 21:47:09
Does anyone here follow new drug news or what's in the pipeline?
Over the years I've seen a lot of things make it to phase III trials and then just quietly disappear.
Right now, new drugs:
Metadoxine - going into phase 3 trials for ADHD and fragile X. - "a nonstimulant 5-hydroxytryptamine receptor antagonist"... I think maybe a 5-HT3 agonist?
Levomilnacipran/Fetzima - just approved - some kind of minacipran derivative - SNRI
ALKS 5461/ Samidorphan-Buprenorphine combo - fast tracked for MDD. Seems fairly novel, a combo of μ-opioid antagonist and mu agonist.
Tedatioxetine - last I heard it was in phase II - serotonin, norepi and dopamine reuptake inhibitor
vortioxetine - SNRI-ish with some other stuff going on. Just approved by the FDA, scored superior to effexor and sweat-balta err, I mean cymbalta with fewer sides.
various orexin antagonists - Merck's got denied by the FDA, there were others; a lot of buzz on this receptor seems to have faded.
Pozanicline - a nicotinic receptor agonist, I thought it was in clinical trials, but it seems to have fallen off the map. Another fizzle?
Anything new you know about?
Posted by Hugh on October 14, 2013, at 12:42:09
In reply to Promising drugs in the clinical trials pipeline?, posted by TriedEveryMedication on October 12, 2013, at 21:47:09
> various orexin antagonists - Merck's got denied by the FDA, there were others; a lot of buzz on this receptor seems to have faded.
The FDA rejected Merck's proposed dosages for Suvorexant. It looks like it will probably still be approved, just at lower dosages. And instead of being approved in the next few months, it might have to wait another year or so.
Way down the pipeline, and probably ten years or so away from being approved, is UCM765. It affects just the MT2 receptor, while melatonin affects both MT1 and MT2. UCM765 promises to be the best sleeping pill ever, as it significantly boosts stage 4 sleep. It may also be helpful for depression and anxiety.
The most promising treatment for unipolar and bipolar I know of in the pipeline is Low-Field Magnetic Stimulation (LFMS).
http://ajp.psychiatryonline.org/article.aspx?articleID=176587
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