Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by vbs on July 24, 2013, at 13:57:06
I now take the following meds:
Cymbalta 60 mg
buspirone 15 mg bid
trazodone 150-300 mg at bedtime for insomnia
Zyprexa 20 mg
Invega SustennaI'm wondering if this combo is okay. Should I worry about serotonin syndrome?
Posted by vbs on July 25, 2013, at 9:43:40
In reply to Buspirone added, posted by vbs on July 24, 2013, at 13:57:06
I think I'll be okay. So far I feel fine. I'm a little more relaxed. I know it takes several weeks to get the full anti-anxiety benefits though. It's not immediate anxiety relief like the benzos. I feel optimistic that this med combo will work.
Posted by Hugh on July 25, 2013, at 11:44:19
In reply to Buspirone added, posted by vbs on July 24, 2013, at 13:57:06
I can't answer your question about the serotonin syndrome, but you might want to add sustained-release melatonin to your combo. This study combined 15 mg of buspirone with 3 mg of sustained-release melatonin. Alone, neither had any antidepressant-like action, but combined, they were very effective.
http://www.ncbi.nlm.nih.gov/pubmed/22998742
This single case study used 5 mg of buspirone combined with 3 mg of melatonin on a woman who had bipolar 1 and treatment-resistant depression.
http://www.alphagalileo.org/viewitem.aspx?itemid=62284&culturecode=en
Posted by vbs on July 25, 2013, at 13:03:22
In reply to Re: Buspirone added, posted by Hugh on July 25, 2013, at 11:44:19
Interesting study. Thanks. I just bought some melatonin. We'll see what happens.
Posted by SLS on July 25, 2013, at 16:20:43
In reply to Re: Buspirone added, posted by Hugh on July 25, 2013, at 11:44:19
> I can't answer your question about the serotonin syndrome, but you might want to add sustained-release melatonin to your combo. This study combined 15 mg of buspirone with 3 mg of sustained-release melatonin. Alone, neither had any antidepressant-like action, but combined, they were very effective.
That's a great idea. It was nice of you to provide the studies.
The effectiveness of melatonin in treating insomnia is dependent upon how it is dosed (dosage and timing). It might be this way for depression and anxiety as well. As an example, some people with insomnia do best when melatonin is given early in the day rather than late in the day. With melatonin, timing is everything. There are several biological clocks. They need to be aligned properly for things to work properly.
- Scott
Posted by Hugh on July 26, 2013, at 10:00:20
In reply to Re: Buspirone added, posted by SLS on July 25, 2013, at 16:20:43
Melatonin acts on both the MT1 and MT2 receptors. An experimental drug, UCM765, binds to just the MT2 receptor, and may turn out to be the best sleeping pill ever developed. Only we'll have to wait years for it.
http://muhc.ca/newsroom/news/tireless-research-reveals-secrets-%E2%80%9Csleep-hormone%E2%80%9D
This is the end of the thread.
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