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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by tecknohed on June 13, 2013, at 18:41:51
Hi all. I was wondering if there existed sustained-release version of amitriptyline. Well I found a product called SAROTEN RETARD (yea for real!).
It was printed in 2000 and also doesn't say which countries it is/was available in.
There are quite a few studies done using slow-release amitriptyline.
So can anyone fill me in? I would love to try SR amitriptyline as I can actually handle the drug during the day and take half my dose in the morning.
Cheers!http://home.intekom.com/pharm/lundbeck/saroten.html
Posted by SLS on June 13, 2013, at 23:02:33
In reply to SAROTEN?, posted by tecknohed on June 13, 2013, at 18:41:51
I take nortriptyline 3 times a day. It is often recommended to take it all at night. I like the idea of establishing a more uniform blood level throughout the day, although I have no evidence that this confers any advantages clinically.
- Scott
Posted by europerep on June 14, 2013, at 1:29:40
In reply to SAROTEN?, posted by tecknohed on June 13, 2013, at 18:41:51
Saroten Retard (amitriptyline) is a product by Bayer Pharmaceuticals, available in Germany and possibly other countries. Depending on where you live, it may be easier to "simulate" a slow-release formula by taking regular amitriptyline two or three times a day, but I totally understand the idea of wanting to try a SR formula. I'm surprised it isn't available where you're at.
The link you posted is a South African package insert, but it's already relatively old, so I'm not sure how up to date it is. But I can confirm that the German version is still on sale as of two weeks ago ;)
Hope this helps!
ER
P.S.: The German word 'Retard' and the English word 'retard' share a common root, but they're not identical. 'Retard' simply means slow-release.
Posted by jono_in_adelaide on June 16, 2013, at 20:10:03
In reply to Re: SAROTEN? » tecknohed, posted by europerep on June 14, 2013, at 1:29:40
Amitriptyline has an intrinsicly long half life, so I'm not sure that a slow release product would confer much advantage over taking the whole days dose at night
Posted by europerep on June 17, 2013, at 9:09:06
In reply to Re: SAROTEN?, posted by jono_in_adelaide on June 16, 2013, at 20:10:03
Mhm, 15-20 hours is not that much. But I generally prefer extended-release formulations, I would probably even take fluoxetine XR if that existed and if I was taking fluoxetine.
Posted by tecknohed on June 17, 2013, at 14:42:48
In reply to Re: SAROTEN? » jono_in_adelaide, posted by europerep on June 17, 2013, at 9:09:06
I take quetiapine XR, 100mg. I know that if I took 50mg IR quetiapine in the morning I would fall asleep, or at least feel groggy. But with the XR version I take the full dose 100mg in the morning & my head stays clear & focussed. As for amitriptyline I awake feeling like I've slept well, and start the day in a positive mood. But I can feel it wearing off by early evening. I did try twice daily but the 50mg amitriptyline knocked me sideways. Perhapse if I got smaller dose pills, say 25mg, I could 'drip feed' it. Of course an XR version would mean not having to remember to take 4 pills at different times and getting confused with all my other meds.
This is the end of the thread.
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