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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Phillipa on January 27, 2013, at 12:29:48
I thought his was old news what's with Pristique now was it not appoved for Major Depression? And Thought already time release? Phillipa
Medscape Medical News > PsychiatryTopline Phase 4 Results for SNRI Released
Deborah Brauser
Jan 24, 2013
Pfizer has announced positive topline results from a phase 4 efficacy study of the selective serotonin and norepinephrine reuptake inhibitor (SNRI) desvenlafaxine (Pristiq) extended-release tablets for the treatment of major depressive disorder (MDD) in adults.
The multicenter, randomized controlled trial included 924 patients with MDD. Those who received for 8 weeks 50 mg/day of desvenlafaxine and those who received 100 mg/day of the medication showed a significant change from baseline on the 17-item Hamilton Rating Scale for Depression (HAM-D17) total score compared with the participants who received matching placebo.
The HAM-D17 was the study's primary efficacy measure. In addition, the company reports that the most common treatment-related adverse events "were consistent with the known safety and tolerability profile of Pristiq."
Previous research has shown that these effects can include nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, and specific male sexual function disorders.
Steven J. Romano, MD, senior vice president and head of the Medicines Development Group for Pfizer, said in a release that these results add to the growing body of evidence that supports desvenlafaxine as a treatment option for those suffering with MDD.
"We know how challenging it can be to treat and manage major depressive disorder. We continue to study Pristiq in order to provide clinicians with more information that can better guide their treatment decisions," said Dr. Romano.
The investigators note that all of the study results will soon be submitted for publication and for presentation at upcoming scientific meetings.
Posted by prefect on January 27, 2013, at 14:36:39
In reply to Topline Phase 4 Results Released For SNRI, posted by Phillipa on January 27, 2013, at 12:29:48
I still don't understand if this class of meds are supposed to gradually upregulate or downregulate the amount of norepinepherin in the brain. If they upregulate it, then it makes sense they help with depression, but no sense at all why they also are supposed to help with anxiety, since norepinepherin is an anxiety hormone.
Posted by Phillipa on January 27, 2013, at 21:10:32
In reply to Re: Topline Phase 4 Results Released For SNRI, posted by prefect on January 27, 2013, at 14:36:39
I guess so a benzo can then be added. Makes no sense to me to take an anxious person say take this med which will make you anxious for awhile and then when the brain adapts you technically feel the same as before you took the first pill. But it's such a relief you don't realize it's back to baseline for you. So why not avoid it all go for the anxiety with an anti anxiety med in the first place. Phillipa
Posted by g_g_g_unit on January 28, 2013, at 7:58:16
In reply to Re: Topline Phase 4 Results Released For SNRI, posted by prefect on January 27, 2013, at 14:36:39
> I still don't understand if this class of meds are supposed to gradually upregulate or downregulate the amount of norepinepherin in the brain. If they upregulate it, then it makes sense they help with depression, but no sense at all why they also are supposed to help with anxiety, since norepinepherin is an anxiety hormone.
Location, location, location, as I've read. NE-type stuff increases certain aspects of anxiety for me (maybe a bit more vigilant), but stimulants (coffee, Dexedrine etc.) can also help a lot with stress and confidence and make me feel more "in control" when it comes to challenging my anxious thoughts.
Posted by SLS on January 28, 2013, at 8:55:02
In reply to Re: Topline Phase 4 Results Released For SNRI » prefect, posted by g_g_g_unit on January 28, 2013, at 7:58:16
> > I still don't understand if this class of meds are supposed to gradually upregulate or downregulate the amount of norepinepherin in the brain. If they upregulate it, then it makes sense they help with depression, but no sense at all why they also are supposed to help with anxiety, since norepinepherin is an anxiety hormone.
>
> Location, location, location, as I've read. NE-type stuff increases certain aspects of anxiety for me (maybe a bit more vigilant), but stimulants (coffee, Dexedrine etc.) can also help a lot with stress and confidence and make me feel more "in control" when it comes to challenging my anxious thoughts.Dexedrine, but not necessarily Ritalin, can reduce anxiety in some people.
- Scott
Posted by prefect on January 28, 2013, at 22:39:20
In reply to Re: Topline Phase 4 Results Released For SNRI » g_g_g_unit, posted by SLS on January 28, 2013, at 8:55:02
Okay now, this is interesting. During anxious states, there used to be a moment I finally felt very strong and centered. It's the point at which I go over the edge and my heart pounds insanely and I feel a rush of something, my legs feel a strange numbness, and my mind finally accepts the situation. It's like the right lense was shifted into focus at the optometrist's office. Some people call this a panic attack.
Ever since I've dozed up Luvox, I can't get this to happen. So I'm constantly in a state of anxious purgatory, with no release. It's driving me nuts!! I need to know what hormone release is being dampened by the Luvox, because I'm convinced it's the very thing that I need to feel to get over my agoraphobia and experience fear extinction.
Norepinepherine? Cortisol? Epinepherine?
I'm stuck in limbo with this feable reaction I'm having these days and I can't stand it!
Could an SNRI help bring this back?
I cured my agoraphobia the last time through panic attacks, and now I can't have them, so I'm just mildly anxious for long periods.
This is the end of the thread.
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