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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by poser938 on January 10, 2013, at 11:04:19
I was looking at the side effects that were reported for minocycline on askapatient.com and more than a few of them reported Lupus-like side effects. What do you think about this.
I'm considering trying it, but this has me a bit nervous. I know you have to compare the risk to benefit posibility for everything. It may be worth the risk.
Posted by poser938 on January 10, 2013, at 11:37:45
In reply to SLS - minocycline, posted by poser938 on January 10, 2013, at 11:04:19
> I was looking at the side effects that were reported for minocycline on askapatient.com and more than a few of them reported Lupus-like side effects. What do you think about this.
>
> I'm considering trying it, but this has me a bit nervous. I know you have to compare the risk to benefit posibility for everything. It may be worth the risk.
And why not just take aspirin?
Posted by Phillipa on January 10, 2013, at 12:08:28
In reply to Re: SLS - minocycline, posted by poser938 on January 10, 2013, at 11:37:45
I know still have the minocycline and current but not taking it as lupus is a sided effect and takes up to a year to disappear if get it. Did you also see the black teeth and gums and nails I think? I wonder about motrin. I know it works at 800 a day as felt wonderful when had to take it 24 hours for a dental proceedure. I took three doses and had the dizziness and headache so the doc removed me from the med and gave me topicals was for perioral dermatitis. Phillipa
Posted by poser938 on January 10, 2013, at 12:58:44
In reply to Re: SLS - minocycline » poser938, posted by Phillipa on January 10, 2013, at 12:08:28
> I know still have the minocycline and current but not taking it as lupus is a sided effect and takes up to a year to disappear if get it. Did you also see the black teeth and gums and nails I think? I wonder about motrin. I know it works at 800 a day as felt wonderful when had to take it 24 hours for a dental proceedure. I took three doses and had the dizziness and headache so the doc removed me from the med and gave me topicals was for perioral dermatitis. Phillipa
I my try the lowest dose of it if my doc will let me. There s soooo much info about minocycline on the internet and its beneficial effects on the brain. Not as much for aspirin. That doesn't necesarily mean minocyclie is better. But minocycline seems to have a more profound effect on toe body nd brain, since it casn cause such intense side effects.
Posted by SLS on January 10, 2013, at 15:53:48
In reply to SLS - minocycline, posted by poser938 on January 10, 2013, at 11:04:19
> I was looking at the side effects that were reported for minocycline on askapatient.com and more than a few of them reported Lupus-like side effects. What do you think about this.
Lupus has been described as being a rare side effect in one article I found. I don't have any statistics handy.
Here are the side effects listed in the standard package label for minocycline (Minocin)
http://www.rxlist.com/minocin-capsules-drug/side-effects-interactions.htm
> I'm considering trying it, but this has me a bit nervous. I know you have to compare the risk to benefit posibility for everything. It may be worth the risk.
It is unfortunate that no statistics are provided with minocycline indicating the frequency with which the side effects occur. If you start to experience dysarthria, I would at that point consider stopping treatment. You can get a blood test for lupus, which would show positive if you were having the lupus reaction. Otherwise the joint pain would represent a more benign side effect.
"Lupus-like syndrome consisting of positive antinuclear antibody; arthralgia, arthritis, joint stiffness, or joint swelling; and one or more of the following: fever, myalgia, hepatitis, rash, and vasculitis."
I would probably stop taking minocyline if joint pain became moderate to severe.
As to your other insightful questions:
There is an ongoing investigation to study aspirin and minocycline as treatments for bipolar depression.
- placebo
- minocycline
- aspirin
- minocycline + aspirinhttp://bmjopen.bmj.com/content/2/1/e000643.full
NSAID or aspirin monotherapy cannot be considered equivalent to taking minocyline. Minocycline works at multiple and diverse sites. Below is a partial list.
-------------------------------------------------
Minocycline:
1. Is neuroprotective.
2. Reduces brain inflammation
3. Reduces the number of glutamate receptors.
4. Demonstrates antidepressant properties in mouse models of depression.
5. Is reported to act synergistically with noradrenergic antidepressants to treat depression - desipramine (but not fluoxetine).
6. Is reported to act synergistically with NMDA antagonists.
7. Reduces glutamate excitotoxicity by reducing the formation of quinolic acid, a NMDA agonist.
8. Reduces mitochondrial release of cytochrome C.
9. Modulates several signaling pathways.
10. Reduces microglial activation.
11. Has been reported anecdotally to successively treat depression.
12. Reduces the expression of lipopolysaccharide-induced pro-inflammation cytokines, an effect that acts as an antidepressant in animal models.
13. Increases neurite growth in response to nerve growth factor (NGF).
14. Inhibits high levels of PKC and GSK-3 alpha;
15. Decreases nitric oxide synthetase, thereby reducing free radicals which damage neurons and glia.
16. Reduces glutamate release.-------------------------------------------------
I am currently taking minocycline 200 mg/day along with a handful of other drugs to treat a very stubborn bipolar depression. It works. I purposely discontinued it a few weeks ago to see if it made a difference. After two weeks of deterioration, I rechallenged with minocycline and now I feel improved again. I found the results of this experimentation persuasive. It could have been an unrelated coincidence, but I am unwilling to repeat the experiment at this juncture.
I must emphasize that minocycline can take several months before a therapeutic response becomes robust and unmistakable. However, my response became recognizable within the first week. Just be prepared to feel somewhat flat and fatigued during the first few days. These side effects disappeared entirely.
- Scott
Posted by poser938 on January 11, 2013, at 10:32:40
In reply to Re: SLS - minocycline » poser938, posted by SLS on January 10, 2013, at 15:53:48
I can't wait for the day when we have medicine that cant cause the same problem it is meant to fix.
This is the end of the thread.
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