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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by idelle on August 6, 2012, at 23:08:02
What is the rationale for taking requip together with zyprexa?
Posted by SLS on August 7, 2012, at 7:36:36
In reply to requip with zyprexa, posted by idelle on August 6, 2012, at 23:08:02
> What is the rationale for taking requip together with zyprexa?
I didn't know there was one.
Interesting.
The combination might help to balance dopamine activity rather than push it too far in one direction or the other. Generally speaking, Requip and Zyprexa have opposite effects at the dopamine synapse. The Zyprexa might buffer the agonist activity of Requip to produce an effect similar to Abilify. Also, Zyprexa provides serotonin 5-HT2a antagonism, which might produce antidepressant effects downstream in the PFC. Requip does not do this. I never tried this combination.
Good luck.
- Scott
Posted by Phillipa on August 7, 2012, at 10:20:48
In reply to Re: requip with zyprexa » idelle, posted by SLS on August 7, 2012, at 7:36:36
Old poster here has been using requip and does take zyprexa at times. He was treatment resistant and now is fine. He's also taken desipramine just stopped and replaced with high dose niacin. Long story short requip took him from brink of suicide to again practicing law, marrying, having a baby. So requip dose work for severe depression. He'd been on all the maois and had ECT also. The zyprexa in the beginning was necessary. Also the desipramine. Phillipa
Posted by phidippus on August 7, 2012, at 21:20:52
In reply to requip with zyprexa, posted by idelle on August 6, 2012, at 23:08:02
To treat restless legs syndrome and psychosis.
Eric
Posted by Novelagent on August 10, 2012, at 20:33:39
In reply to Re: requip with zyprexa » idelle, posted by phidippus on August 7, 2012, at 21:20:52
If zyprexa is causing akathsia, a dopamine agonist can help allieviate it (akathisia is inner restlessness). But it sounds like there's other uses. Dopamine agonists for akathsia only work for a certain number of months, maybe a year or longer, even, and then run the risk of having tolerance to that effect and the akathsia coming back.
Zofran works for akathsia, according to one study. Rhodolia also works, but long-term use carries the risk or arterial fibrilation with rhodolia, so one has to be monitored for that.
Posted by Phillipa on August 11, 2012, at 20:03:22
In reply to Re: requip with zyprexa, posted by Novelagent on August 10, 2012, at 20:33:39
Zofran isn't that an antiemetic? Phillipa
Posted by Phillipa on August 11, 2012, at 20:11:43
In reply to Re: requip with zyprexa, posted by Novelagent on August 10, 2012, at 20:33:39
I don't get it as if it blocks serotonin what does this mean less of course but if depressed don't you need it? Serotonin that is? Phillipa
Posted by Novelagent on August 12, 2012, at 11:03:55
In reply to Re: requip with zyprexa » Novelagent, posted by Phillipa on August 11, 2012, at 20:11:43
> I don't get it as if it blocks serotonin what does this mean less of course but if depressed don't you need it? Serotonin that is? Phillipa
>
> http://www.drugs.com/zofran.htmlIt blocks 5-2HTA receptors, which are a type of serotonin receptors; SSRIs generally hit more than just 5-2HTA.
Also, it only modulates it somewhat-- I wouldn't say it "blocks serotonin" as in it depletes it or anything. Zofran is not associated with depression, and the idea of having too little serotonin being the cause of depression (imbalance hypothesis) has been disproven-- it turns out, people with plenty of serotonin get depressed all the time.
This is the end of the thread.
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