![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by Reggie BoStar on December 1, 2011, at 12:42:53
Hey Everyone,
I was wondering if anyone has been taking the new SSRI Viibryd (Vilazodone).The spin: Merck claims that it doesn't cause sexual dysfunction as with most of the other SSRIs.
The catches:
1. The FDA is now questioning the claims about sexual dysfunction, suggesting that Viibryd really doesn't do anything unique compared to other SSRIs.
2. My pdoc (and the Wiki article linked below) reports that new users of Viibryd are having problems with chronic nausea and drowsiness. He also said that it's been too soon to know whether or not sexual dysfunction is a problem.
3. It's an SSRI. If you're used to taking SNRI's like Pristiq (that's me), Cymbalta, etc, you won't get the benefit of whatever a mixed Serotonin/Norepinephrine reuptake inhibitor has been giving you - you'll be taking the Serotonin reuptake inhibitor component only, as in Prozac and the other older SSRIs.
I've been taking SNRIs for so long now that I have no idea what the "NRI" component is contributing to the overall effect, if anything.
Yesterday my pdoc advised me to wait until more information on Viibryd's pros and cons becomes available.
Here's a link to the Wiki article on Viibryd (spelled with two ii's, just to mess up search engines). It has good references that can be checked for accuracy:
http://en.wikipedia.org/wiki/Viibryd
Has anyone had any experience with Viibryd pro/con, thus far? Anything to report on nausea, sexual dysfunction?
Happy Holidays,
Reggie BoStar
Posted by Phillipa on December 1, 2011, at 15:43:35
In reply to Anyone taking Viibryd?, posted by Reggie BoStar on December 1, 2011, at 12:42:53
Reggie there recently have been a few on viibryd. Maybe some still on this page? Happy Holidays to you also. Phillipa
Posted by Reggie BoStar on December 1, 2011, at 17:55:29
In reply to Re: Anyone taking Viibryd? » Reggie BoStar, posted by Phillipa on December 1, 2011, at 15:43:35
Hi Phillipa,
I didn't find any on this page but I was lazy and didn't give the entire site a try.Thanx and happy holidays to you!
Reggie BoStar
Posted by Reggie BoStar on December 1, 2011, at 18:25:42
In reply to Re: Anyone taking Viibryd? » Reggie BoStar, posted by Phillipa on December 1, 2011, at 15:43:35
Hey Phillipa,
Argh! I see the other thread now. I fell victim to the very mistake I warned about in my first message - searched on Vibryd instead of Viibryd.Anyway, here's a copy of some of the link info I posted on that other thread. I wanted to add it to this one eventually too.
My pdoc suggested that I keep an eye on the websites below. From what I've seen, Daniel Carlat is a consumer advocate of sorts who provides useful info on pharmaceuticals. His take on Viibryd, and the issue of sexual dysfunction side effects in general, is worth a read.
The article about Viibryd and a few more of the newer meds is on the report website, entitled "Four 'New' Antidepressants".
Report
http://thecarlatreport.com/Blog
http://carlatpsychiatry.blogspot.com/One thing he points out is that the 5-HT reuptake
mechanism is very similar to what BusPar does.The GI side effects (nausea, diarrhea) were pretty significant in the study by the mfg, Forest Labs. They say that 23% of the subjects reported problems with diarrhea, and 28% with nausea. That's vs 5% and 9% respectively for the placebo group.
Anyone else have something to report on Viibryd?
Reggie BoStar
Posted by Phillipa on December 1, 2011, at 20:24:26
In reply to Re: Anyone taking Viibryd? » Phillipa, posted by Reggie BoStar on December 1, 2011, at 18:25:42
Oh I did google it on patient reviews and some were good. Phillipa
Posted by Phidippus on December 4, 2011, at 21:18:19
In reply to Anyone taking Viibryd?, posted by Reggie BoStar on December 1, 2011, at 12:42:53
I have experienced no sexual dysfunction since being on Viibryd for 2 months now. In fact, it reduced the side effect of anorgasmia imparted by another drug I take, Clomipramine.
I have not experienced any nausea or drowsiness.
The NRI in SNRI stands for norepinephrine reuptake inhibition. More norepinephrine=less anxiety and depression.
Eric
Posted by Phillipa on December 4, 2011, at 22:58:31
In reply to Re: Anyone taking Viibryd? » Reggie BoStar, posted by Phidippus on December 4, 2011, at 21:18:19
Eric if more epinephrine equates less anxiety then wouldn't that make the SNRI's better for anxiety than SSRI's? Phillipa
Posted by Reggie BoStar on December 4, 2011, at 23:46:14
In reply to Re: Anyone taking Viibryd? » Reggie BoStar, posted by Phidippus on December 4, 2011, at 21:18:19
I take this to mean that I'd experience more anxiety on Viibryd (SSRI) than I do on Pristiq (SNRI)?
Even with the "NRI" effect of the Pristiq on anxiety, I still have to take Buspar to keep myself off the ceiling!
Reggie BoStar
Posted by iforgotmypassword on December 5, 2011, at 14:55:01
In reply to Re: Anyone taking Viibryd? » Phidippus, posted by Reggie BoStar on December 4, 2011, at 23:46:14
it's a 5-ht1a agonist that increases serotonin. i'm not sure this makes a lot of sense. it's really worth questioning whether its an in vivo 5-ht1a agonist at all
Posted by Phidippus on December 5, 2011, at 16:48:14
In reply to Re: Anyone taking Viibryd? » Phidippus, posted by Reggie BoStar on December 4, 2011, at 23:46:14
Not necessarily. Viibryd is a 5ht1a partial agonist which helps with anxiety and depression. Its a pretty potent mechanism.
Eric
Posted by Phidippus on December 5, 2011, at 17:02:01
In reply to Re: Anyone taking Viibryd? » Phidippus, posted by Phillipa on December 4, 2011, at 22:58:31
The effects are alertness and arousal, and influences on the reward system. Differences in the norepinephrine system are implicated in depression. Serotonin-norepinephrine reuptake inhibitors are antidepressants that treat depression by increasing the amount of serotonin and norepinephrine available to postsynaptic cells in the brain. There is some recent evidence implying that SNRIs may also increase dopamine transmission.
Elevation of norepinephrine levels can sometimes cause anxiety, mildly elevated pulse, and elevated blood pressure. People at risk for hypertension and heart disease should have their blood pressure monitored.
Eric
Posted by Phillipa on December 5, 2011, at 18:15:57
In reply to Re: Anyone taking Viibryd? » Phillipa, posted by Phidippus on December 5, 2011, at 17:02:01
Cymbalta at 60mg with benzo on board didn't bother me at all. Phillipa
Posted by Phidippus on December 7, 2011, at 15:03:54
In reply to Re: Anyone taking Viibryd? » Phidippus, posted by Phillipa on December 5, 2011, at 18:15:57
You love your benzos!
Eric
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.