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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 6 to 30 of 30. Go back in thread:
Posted by markwell on November 5, 2011, at 11:21:20
In reply to Re: agomolatine » markwell, posted by jhj on November 5, 2011, at 7:31:33
I don't see where it is discontinued. The article said there is less discontinuation effects than other ads. I think its still under consideration.
Posted by linkadge on November 5, 2011, at 20:20:41
In reply to Re: agomolatine » Franz, posted by Phidippus on November 4, 2011, at 20:03:12
Its efficacy as an antidepressant is often called into qquestion. (by who?)
Posted by linkadge on November 5, 2011, at 20:22:19
In reply to Re: agomolatine » markwell, posted by jhj on November 5, 2011, at 7:31:33
that sucks
Posted by jhj on November 6, 2011, at 23:15:05
In reply to Re: agomolatine, posted by markwell on November 5, 2011, at 11:21:20
Excuse me? It is clearly written in the last paragraph of "history" section:"However, the development for the US market was discontinued in October 2011, when the results from the last of those trials became available.[9]
You can also see the same in following link:
http://www.scripintelligence.com/home/Novartis-drops-future-blockbuster-agomelatine-322880
Posted by markwell on November 7, 2011, at 8:45:52
In reply to Re: agomolatine » markwell, posted by jhj on November 6, 2011, at 23:15:05
I'm sorry. I didnt read the history tab. I'm very dissapointed.
Mark
Posted by avenarius on November 7, 2011, at 22:39:38
In reply to agomolatine, posted by markwell on November 4, 2011, at 12:42:18
no reason to be disappointed. i took it for a year and it was no better than paxil or any of the others.
Posted by ed_uk2010 on November 8, 2011, at 10:06:39
In reply to agomolatine, posted by markwell on November 4, 2011, at 12:42:18
We have it here... but no one takes it. Well, very few indeed. Perhaps it wasn't marketed effectively.
Posted by Phillipa on November 8, 2011, at 18:04:57
In reply to Re: agomolatine, posted by ed_uk2010 on November 8, 2011, at 10:06:39
Hi stranger miss you. So ago isn't the best med? Love PJxxxx
Posted by ed_uk2010 on November 9, 2011, at 5:50:33
In reply to Re: agomolatine » ed_uk2010, posted by Phillipa on November 8, 2011, at 18:04:57
> Hi stranger miss you. So ago isn't the best med? Love PJxxxx
Hi PJ,
Yeah, I decided to visit Dr. Bob's :)
I wouldn't say that lack of use means it's bad. I don't think it's been effectively promoted.
Posted by Franz on November 9, 2011, at 11:33:30
In reply to Re: agomolatine, posted by linkadge on November 5, 2011, at 20:20:41
> Its efficacy as an antidepressant is often called into qquestion. (by who?)
http://www.ncbi.nlm.nih.gov/pubmed/20020562
also see the wikipedia article
I don´t mean it does not work, also I am not the original poster, but I read several articles on ago.
Posted by Phillipa on November 9, 2011, at 18:00:40
In reply to Re: agomolatine » Phillipa, posted by ed_uk2010 on November 9, 2011, at 5:50:33
Ed anyone you know take it or report if it works for them or not? Glad you are on babble. So many have missed you. PJ
Posted by ed_uk2010 on November 10, 2011, at 5:31:59
In reply to Re: agomolatine » ed_uk2010, posted by Phillipa on November 9, 2011, at 18:00:40
> Ed anyone you know take it or report if it works for them or not? Glad you are on babble. So many have missed you. PJ
Thanks PJ. I've never known anyone who takes it, it's really rarely used.
Posted by Tepi on November 10, 2011, at 20:02:59
In reply to agomolatine, posted by markwell on November 4, 2011, at 12:42:18
> Any word on when this drug will be approved in the US? Haven't heard anything about the drug in a long time. Is it supposed to be effective for anxiety? I'd appreciate any updates.
> MarkI took it for a month at nigths but it was soo strong that in the morning I couldnt get awake from bed and I used to drive my car almost sleeping ,closing my eyes all the time. I hate that drug
Posted by ed_uk2010 on November 11, 2011, at 5:37:12
In reply to Re: agomolatine, posted by Tepi on November 10, 2011, at 20:02:59
> > Any word on when this drug will be approved in the US? Haven't heard anything about the drug in a long time. Is it supposed to be effective for anxiety? I'd appreciate any updates.
> > Mark
>
> I took it for a month at nigths but it was soo strong that in the morning I couldnt get awake from bed and I used to drive my car almost sleeping ,closing my eyes all the time. I hate that drug
>
>That's a shame Tepi. How are you feeling at the moment anyway? Nice to see your name.
Posted by sigismund on November 12, 2011, at 1:56:10
In reply to Re: agomolatine, posted by ed_uk2010 on November 8, 2011, at 10:06:39
>We have it here... but no one takes it.
I take it, but then I asked for it, after importing it for years. My psych has no drug company connections which helps.
Posted by Phillipa on November 12, 2011, at 19:01:02
In reply to Re: agomolatine » ed_uk2010, posted by sigismund on November 12, 2011, at 1:56:10
Sigi you do? Since the board opened? PJ
Posted by psychobot5000 on November 14, 2011, at 12:59:40
In reply to Re: agomolatine » ed_uk2010, posted by sigismund on November 12, 2011, at 1:56:10
I took it for some weeks. It helped a bit initially--5HT-2c blockade, woo-hoo--but then exacerbated my OCD--5HT-2C blockade, woo-hoo!--and seriously increased my depression--MT receptor agonism, woo-hoo!
My guess is that MT receptor action is also what prevents it from getting good numbers as an antidepressant, but it could just be that 5HT-2C isn't enough on its own. In any case, it was just another disappointment for me. Hard to say whether it would have been useful to anyone in the long term.
Posted by sigismund on November 15, 2011, at 4:00:00
In reply to Re: agomolatine, posted by psychobot5000 on November 14, 2011, at 12:59:40
>Hard to say whether it would have been useful to anyone in the long term.
It is vaguely pleasant (for me) though there's not much competition that I can easily get.
I take 12.5 mostly but sometimes 25.
Posted by Phillipa on November 15, 2011, at 18:17:31
In reply to Re: agomolatine, posted by sigismund on November 15, 2011, at 4:00:00
Is the board still up and running? M around? PJ
Posted by ed_uk2010 on November 16, 2011, at 6:54:45
In reply to Re: agomolatine » sigismund, posted by Phillipa on November 15, 2011, at 18:17:31
>Is the board still up and running? M around? PJ
What board PJ?
Posted by sigismund on November 17, 2011, at 21:48:35
In reply to Re: agomolatine » Phillipa, posted by ed_uk2010 on November 16, 2011, at 6:54:45
Agomelatine psychonauts.
Yeah, it's still up, but not much has been happening lately.
Posted by Phillipa on November 17, 2011, at 23:52:43
In reply to Re: agomolatine » ed_uk2010, posted by sigismund on November 17, 2011, at 21:48:35
Hardly ever get any post from there. Where is Marty? PJx
Posted by ed_uk2010 on November 18, 2011, at 12:00:02
In reply to Re: agomolatine » ed_uk2010, posted by sigismund on November 17, 2011, at 21:48:35
>psychonauts...
Psychonauts? Sounds more like a website about a hallucinogen.
Posted by sigismund on November 18, 2011, at 16:24:08
In reply to Re: agomolatine » sigismund, posted by ed_uk2010 on November 18, 2011, at 12:00:02
Not everyone finds it dysphoric. I guess that might be why.
Posted by ed_uk2010 on November 19, 2011, at 7:13:16
In reply to Re: agomolatine » ed_uk2010, posted by sigismund on November 18, 2011, at 16:24:08
> Not everyone finds it dysphoric.
That could apply to a lot of meds though Sigi.
This is the end of the thread.
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