Psycho-Babble Medication Thread 999726

Shown: posts 1 to 14 of 14. This is the beginning of the thread.

 

Do risperdal or seroquel block autoreceptors?

Posted by poser938 on October 14, 2011, at 18:47:54

I was wondering if seroquel or risperdal block the dopamine autoreceptors like they block the postsynaptic receptors. havent been able to really find any info on the web, so if anyone cann tell me, that would be great. and if you can give me a resource that would be even better.

oh and let me add, i know there is a med that blocks just the autreceptos at low doses (amisulpride) but im wondering if normal doses of reisperdal or seroquel block dopamine autoreceptors?

 

Re: Do risperdal or seroquel block autoreceptors? » poser938

Posted by SLS on October 14, 2011, at 19:41:02

In reply to Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 14, 2011, at 18:47:54

> I was wondering if seroquel or risperdal block the dopamine autoreceptors like they block the postsynaptic receptors. havent been able to really find any info on the web, so if anyone cann tell me, that would be great. and if you can give me a resource that would be even better.
>
> oh and let me add, i know there is a med that blocks just the autreceptos at low doses (amisulpride) but im wondering if normal doses of reisperdal or seroquel block dopamine autoreceptors?

You might consider that all neuroleptics *increase* dopamine turnover by increasing the synthesis and release of this neurotransmitter. This is facilitated by their antagonistic action on presynaptic autoreceptors. Look for literature that describes this.


- Scott

 

Re: Do risperdal or seroquel block autoreceptors?

Posted by poser938 on October 14, 2011, at 20:18:33

In reply to Re: Do risperdal or seroquel block autoreceptors? » poser938, posted by SLS on October 14, 2011, at 19:41:02

thanks, and uhmm.. do you know if postsynaptic antagonism has any different effects on dopamine release? does it decrease it?

 

Re: Do risperdal or seroquel block autoreceptors?

Posted by poser938 on October 14, 2011, at 20:24:39

In reply to Re: Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 14, 2011, at 20:18:33

or is the only reason why you cant feel this increase in dopamine because of the postsynaptic antagonism??

hope im making sense?

 

Re: Do risperdal or seroquel block autoreceptors?

Posted by poser938 on October 14, 2011, at 20:39:57

In reply to Re: Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 14, 2011, at 20:24:39

the thing is, im trying to treat my seemingly permanent mirapex induced anhedonia. i have tried risperdal and seroquel and with both of those it was like taking a sugar pill. (i guess because the dopamine activity in my brain is so low). and now im finally on amisulpride for the low dose effect on autoreceptors andddd i still feel nothing!!! like taking a sugar pill again.

 

Re: Do risperdal or seroquel block autoreceptors? » poser938

Posted by Chairman_MAO on October 14, 2011, at 22:43:24

In reply to Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 14, 2011, at 18:47:54

You want a drug more like this:

http://en.wikipedia.org/wiki/Roxindole

The neuroleptics are not going to do what you want.

 

Re: Do risperdal or seroquel block autoreceptors? » poser938

Posted by SLS on October 14, 2011, at 23:08:32

In reply to Re: Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 14, 2011, at 20:24:39

> or is the only reason why you cant feel this increase in dopamine because of the postsynaptic antagonism??

Yes.

:-)

> hope im making sense?

Yes. Perfect sense.


- Scott

 

Re: Do risperdal or seroquel block autoreceptors? » poser938

Posted by Chairman_MAO on October 14, 2011, at 23:12:18

In reply to Re: Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 14, 2011, at 20:39:57

You could give selegiline a shot or perhaps memantine.

How permanent is permanent? Permanent is a strong statement.

 

Re: Do risperdal or seroquel block autoreceptors?

Posted by poser938 on October 14, 2011, at 23:52:54

In reply to Re: Do risperdal or seroquel block autoreceptors? » poser938, posted by Chairman_MAO on October 14, 2011, at 23:12:18

I took Mirapex for a month in october 2009. i took the mirapex to treat some slight numbing of emotions and a decreased libido that were still left over from past use of effexor, even though i had been off effexor for 2 years. for the 1st month on mirapex it increased my sensitivity to sexual stimulation with no effect on my mood. after that month the effects of it reversed and anhedonia hit me... and it wasnt going away after stopping so next i tried tianeptine. it made me worse. then i took 1 dose of ritalin and it made me worse... then i tried cyproheptadine after reading alot about 5ht2c antagonism,and it helped me for a few months and then it just stopped working after i got to a much too high dose. so more recently i thought, whi dont i just try meds that work the opposite of mirapex to see if they will help. i tried risperdal 1st for about 7 weeks with no effect at all. and then i was a mental inpatient a month and a half ago and the doc there gave me an 8day supply of seroquel, starting out at 50mgs and i got up to 150 mgs by the 4th day, and and i felt no effects from it.

so now im on amisulpride. i have tried 25mgs and once again felt NOTHING! but i've only been on it for a few days.. although most people experience stimulation during the 1st days of taking amisulpride, it has been a sugar pill so far. i'm going to give the amisulpride at least a full 6 weeks though. but i am just worried. i have considered selegiline, but i am afraid it could just make me worse like the tianeptine and ritalin did. i have also been taking N-Acetylcysteine for 11 days now after someone mentioned a good experience from it in their mirapex induced anhedonia, but so far i have felt no effects form it. i am just not sure what else to do.

 

Re: Do risperdal or seroquel block autoreceptors? » poser938

Posted by Chairman_MAO on October 15, 2011, at 11:21:08

In reply to Re: Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 14, 2011, at 23:52:54

Please excuse me if I asked this already--I'm in a fog for a while--but have you tried any of the irreversible, non-selective MAO inhibitors (Nardil, Parnate, Marplan)?

 

Re: Do risperdal or seroquel block autoreceptors?

Posted by poser938 on October 15, 2011, at 13:07:25

In reply to Re: Do risperdal or seroquel block autoreceptors? » poser938, posted by Chairman_MAO on October 15, 2011, at 11:21:08

haha it's cool if your in a fog, im in a fog too. but, not i havent tried any irreversible MAO inhibitors. after my experiences with tianeptine and ritalin i am afraid of dopamine increasing meds. before i mirapex messed up my brain i could easily tolerate a stimulant. but now, like i said after 1 dose of ritalin, my anhedonia was made worse. i'm just confused and am not sure what to do, i'm just trying to be very careful about what meds i take. i may go back to the same inpatient hospital i went to last month, the psychiatrist there seemed to have knowledge far ahead of any other psychiatrist i have been to.

 

Re: Do risperdal or seroquel block autoreceptors? » poser938

Posted by Chairman_MAO on October 15, 2011, at 18:00:14

In reply to Re: Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 15, 2011, at 13:07:25

Dopaminergic drugs have many mechanisms of action. "Dopamine increasing" is not a very descriptive term.

If you have treatment-resistant depression, it makes sense to try an MAOI. From there, you can augment it with something else if necessary.

 

Re: Do risperdal or seroquel block autoreceptors?

Posted by poser938 on October 16, 2011, at 17:58:35

In reply to Re: Do risperdal or seroquel block autoreceptors? » poser938, posted by Chairman_MAO on October 15, 2011, at 18:00:14

yah im just scared of meds, most seem to have permanent effects on me.. which is why im in the situation i am in right now.

 

Re: Do risperdal or seroquel block autoreceptors? » poser938

Posted by Chairman_MAO on October 18, 2011, at 20:48:17

In reply to Re: Do risperdal or seroquel block autoreceptors?, posted by poser938 on October 16, 2011, at 17:58:35

> yah im just scared of meds, most seem to have permanent effects on me.. which is why im in the situation i am in right now.

Well, unfortunately it's either try medication or do not try medication. Perhaps you need to consult with a neurologist if you feel that medication has had such untoward long-term effects? It is possible, but this sort of thing is very complex and you'd need a consult with an expert.

If you're going to try medication, given your concerns it makes sense to try the drugs that have been in clinical use the longest that are most effective. MAOIs fall into that category.


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