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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Zyprexa on September 23, 2011, at 1:36:06
This new combo with less bupropion sr and perphenazine. I think a lot of it has to do with the lower bupropion, I'm less anxious drink a lot less, fully given up the cigs for the last 5 days (was at 1 cig a day for a while), and I'm going to the gym more than once a week now. I think giving up the 4mg x3 perphenazine was just there to counter the bupropion. So my current combo is 15mg zyprexa split, 150 sertraline, 8mg x3 perphenazine and 100 bupropion sr. I feel a whole lot better and don't act as insensative as before, atleast it seems so, more down to earth. Probably from the decrease in perphenazine. I feel so good now that I'm uncertain if it would be good to decrease these 2 any further, or to just stick with it. It also took a bit of time to adjust to the change, where I was out of wack for a while, but now I feel better than before! I'm sure the doc is going to try and reduce more next time, but should I or go with this for a while longer?
Posted by Christ_empowered on September 23, 2011, at 2:04:34
In reply to I feel Great!, posted by Zyprexa on September 23, 2011, at 1:36:06
I'm glad you're feeling and doing so much better. I don't know what to tell you about the perphenazine. On the one hand, the lowest dose antipsychotic (and the fewest number of antipsychotics taken at one time) is usually what's recommended. On the other hand, you do what you have to do to get and stay well.
Is the perphenazine there to keep psychosis at bay, or is it more of an anti-anxiety thing? Could upping the zyprexa allow you to drop the perphenazine?
Posted by Zyprexa on September 23, 2011, at 2:53:18
In reply to That's awesome!, posted by Christ_empowered on September 23, 2011, at 2:04:34
Before the perphenazine I was taking 20-30mg zyprexa. And 300mg bupropion. At the time I was all messed up from 6 months on abilify and then 2 years of geodon. Before that I was taking low dose zyprexa, which didn't work well. They tried psycho therapy on me to get me to think straight and not worry or be anxious, but it didn't work. Before all of it I had realy good results from 10mg zyprexa for a number of years. So my hope is to eventualy get rid of perphenzine and wellbutrin, and maybe even get back down to 10mg zyprexa with sertraline. I think a lot of my problems came on when the doc added bupropion, but I'm not complaining because it got me to quit smoking. Even thought I very anxious from the bupropion, and messed up from all the med changes, Ie the APs. The origional hope for perphenazine was that it would replace the zyprexa. So I started the perphenazine and decreased the zyprexa to 5mg, then it was very obvious that I couldn't get off the zyprexa. So I took both for years. Seemed that it was helping something, probably anxiety from the bupropion. Finaly the doc clued in that I was anxious at my last visit and sleeping 12h a day and told me to make the reductions. But not at the same time. So first I reduced the perphenazine and my anxiety spiked, so I reduced the bupropion and now I'm better, even better that before.. So now I'm thinking get rid of bupropion. And probably won't need the perphenazine. Which would be good. The doc gave me 5mg zyprexa's to take for when the anziety is realy bad but the only time I took it was right after perphenazine reduction and not since the bupropion reduction.
Posted by SLS on September 23, 2011, at 5:28:14
In reply to I feel Great!, posted by Zyprexa on September 23, 2011, at 1:36:06
> I think giving up the 4mg x3 perphenazine was just there to counter the bupropion.
Good thought.
- Scott
Posted by jerseygal1 on September 23, 2011, at 10:21:01
In reply to Re: I feel Great! » Zyprexa, posted by SLS on September 23, 2011, at 5:28:14
That's great! I'm so glad for you. It's so nice to see happy news for a change.
Posted by Phillipa on September 23, 2011, at 10:32:30
In reply to I feel Great!, posted by Zyprexa on September 23, 2011, at 1:36:06
Zyprexa never knew you took more than the antipsychotics. Don't you need them though as don't you have a schizoaffective disorder or did diagnosis change? You sound wondeful. I think I'd leave it for now. This is truly marvelous!!! Phillipa
Posted by floatingbridge on September 23, 2011, at 16:32:50
In reply to Re: That's awesome!, posted by Zyprexa on September 23, 2011, at 2:53:18
It is awesome :-)
I love this, when meds and treatment seem to fall into place or make sense.
I'm glad to hear your good news! Thank you.
Posted by Zyprexa on September 24, 2011, at 4:36:06
In reply to Re: I feel Great! » Zyprexa, posted by Phillipa on September 23, 2011, at 10:32:30
Ya, I agree with you Phillipa. Decided today at work that a further reduction might not be such a good idea. I still like the current combo though! Think I will stick with it for a while. Yes I'm still schitzoaffective. I think the main pill fixing it is still the zyprexa. Its the one med that I have never been totaly off of for more than 5 days at a time in the last 11 years.
Posted by hyperfocus on September 25, 2011, at 14:30:28
In reply to I feel Great!, posted by Zyprexa on September 23, 2011, at 1:36:06
It's good to hear you're doing better Z. If I were you I'd stay at the current dosage. Meds in combination can have a therapeutic window or balance that you can only find through trial and error. Reducing or changing anything can upset this balance and more importantly you may not be able to achieve it when you restart.
Seriously I think it's really important you stay on your current meds at your current dosages - it's the one thing I always tell posters here. If you don't feel like you're close to 100% remember it can take a number of weeks or months to decide if your current combo has you on the path to remission. You should wait for a couple of weeks AT LEAST before trying to change things.
Good luck to you and I hope your success continues.
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