![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by linkadge on September 16, 2011, at 20:25:25
I've been reading up on h1 receptor antagonists. Apparently, h1 receptors are upregulated in depression, and, in animal models, h1 receptor antagonists produce antidepressant effects.
h1 receptor antagonists induce serotonin / norepinephrine release in certain brain regions.
Linkadge
Posted by Phillipa on September 16, 2011, at 23:29:51
In reply to antihistamines as antidepressants, posted by linkadge on September 16, 2011, at 20:25:25
Thanks so do SSRI's really work in your opinion? Phillipa
Posted by FrustratedMama on September 17, 2011, at 10:10:35
In reply to Re: antihistamines as antidepressants » linkadge, posted by Phillipa on September 16, 2011, at 23:29:51
In my experience....which is probably not typical.... antihistamines have made things worse....they relieve some of the congestion due to allergies but make me more unstable.....just my experience....
Posted by linkadge on September 17, 2011, at 13:17:45
In reply to Re: antihistamines as antidepressants, posted by FrustratedMama on September 17, 2011, at 10:10:35
The instability effect may be more due to the anticholinergic effect of antihistamines than the antihistamine effect.
Linkadge
Posted by FrustratedMama on September 17, 2011, at 14:11:27
In reply to Re: antihistamines as antidepressants, posted by linkadge on September 17, 2011, at 13:17:45
Is there a way to combat that?
Posted by linkadge on September 17, 2011, at 16:24:32
In reply to Re: antihistamines as antidepressants » linkadge, posted by FrustratedMama on September 17, 2011, at 14:11:27
We would need a selective h1 antagonist which we don't have.
Linkadge
Posted by bleauberry on September 17, 2011, at 18:15:02
In reply to antihistamines as antidepressants, posted by linkadge on September 16, 2011, at 20:25:25
Sounds good to me.
Hey if I remember correctly, I think Prozac was invented from a take-off of benadryl or something like that?
Anyway what you said makes sense to me. I guess the questions would be what substances, what doses, and how long?
Posted by linkadge on September 17, 2011, at 20:00:47
In reply to Re: antihistamines as antidepressants, posted by bleauberry on September 17, 2011, at 18:15:02
I don't know. You can do a google search for h1 or histamine + depression. Apparently histamine activity is high in some models of depression and low in models of schizophrenia.
Linkadge
Posted by SLS on September 17, 2011, at 23:41:31
In reply to Re: antihistamines as antidepressants, posted by linkadge on September 17, 2011, at 20:00:47
> I don't know. You can do a google search for h1 or histamine + depression. Apparently histamine activity is high in some models of depression and low in models of schizophrenia.
Intuitively, that makes sense. Thanks for the information.
- Scott
Posted by jono_in_adelaide on September 19, 2011, at 18:02:35
In reply to Re: antihistamines as antidepressants » linkadge, posted by FrustratedMama on September 17, 2011, at 14:11:27
Quiter a few antidepressants have antihistaminic activity.... amitriptyline, imipramine, doxepin, dothiepin, mirtazepine and many others, they are "multimodal" antidepressants, and produce more robust effects than single action agents.
Sometimes "dirty" drugs are better
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.