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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 19 to 43 of 43. Go back in thread:
Posted by SusanWhelan on July 13, 2011, at 17:33:35
In reply to Re: Is anyone using Deplin still?, posted by mogger on June 28, 2011, at 19:22:27
Hi, I work with Deplin. Thanks for the testimonial, Henryo. I have previously answered questions for Phillipa, but maybe I can give all of you some additional information?
As you probably know, Deplin is l-methyfolate, the active form of folate and is prescribed to augment other treatment of depression. Deplin works to manage the monamines associated with mood. It is considered a medical food, not a drug.
A recent study of the 15 mg dose as adjunctive therapy showed a superior response- with 2x the patients responding- and an 84% reduction in depressive symptoms compared to antidepressant + placebo.
Some patients may need to take 4-6 weeks to see complete response.
You do not need to have MTHFR to see results from Deplin but it is estimated that 70% of depressed patients is affected by MTHFR polymorphism (compared to 50% of the general population).
You might find these articles helpful:
http://www.psychologytoday.com/blog/inner-source/201106/folic-acid-the-equalizing-b-vitaminhttp://dailywd.womansday.com/health/daily-dose/2011/antidepressants/
http://chipur.com/2011/05/19/update-l-methylfolate-and-depression-more-good-news/
For those of you that do not purchase through insurance, there is a savings program through Brand Direct Health, available on the Deplin website.
I hope this information helps.
Posted by mogger on July 13, 2011, at 18:17:46
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 13, 2011, at 17:33:35
Thanks so much for the reply. I just was at my General Practitioner yesterday who was supportive of Deplin and gave me plenty of samples to try. He has had great success with it but as you say he says it takes a while to work. He was nice enough to listen to me and was happy to order the MTHFR test which I am awaiting the results. Many thanks again,
Joseph
Posted by Phillipa on July 13, 2011, at 21:41:56
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 13, 2011, at 17:33:35
Susan thanks for the links. When another webcam comes up let us know? Phillipa
Posted by SusanWhelan on July 14, 2011, at 7:13:31
In reply to Re: Is anyone using Deplin still? » SusanWhelan, posted by Phillipa on July 13, 2011, at 21:41:56
Sure, I'll post when we host another webinar.
Posted by Phillipa on July 14, 2011, at 20:34:41
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 14, 2011, at 7:13:31
Susan I'm sure others would appreciate this. Since we started talking Deplin again have heard from other posters that their docs are having good success. Any comments or statistics? Phillipa
Posted by SusanWhelan on July 18, 2011, at 18:22:03
In reply to Re: Is anyone using Deplin still? » SusanWhelan, posted by Phillipa on July 14, 2011, at 20:34:41
I'm not sure what you mean. Do you want statistics from the study?
The clinical trials can be found here:
http://www.deplin.com/HealthcareProfessionals,TrialsThe most recent study is the first one on that web page, which is often referred to as the "Fava study." In that study, 32.2% of the participants responded to Deplin 15mg + antidepressant in 30 days. Of the patients that responded, they showed an 84% greater reduction in depressive symptoms.
Here is another article that may help:
http://www.foxnews.com/health/2011/06/02/vitamin-that-fights-depression/
Posted by Phillipa on July 18, 2011, at 21:54:33
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 18, 2011, at 18:22:03
Thanks Susan you are an asset to this medication board and speak for Others also when I say I do appreciate the links thanks again so much!!! Phillipa
Posted by sac on July 20, 2011, at 6:16:21
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 18, 2011, at 18:22:03
I was recently prescribed Deplin 15 mgs. to augment my AD's. I started with 7.5 mgs and never made it up to 15 mgs because I could not sleep at night. I was on this dose for a week when I developed numbness alternating with burning in my feet. I have never experienced this before. I discontinued the Deplin two weeks ago and the burning/numbness has improved but is not entirely gone. I am worried about this, is Deplin associated with nerve damage?
Posted by SusanWhelan on July 20, 2011, at 10:41:36
In reply to Re: Is anyone using Deplin still? My strange exp., posted by sac on July 20, 2011, at 6:16:21
Any new symptoms or side effects of any medication should be discussed with your doctor. You can find information on what to expect with Deplin here. http://www.deplin.com/DeplinFacts,WhatToExpect
Deplin has not been associated with weight gain, sexual dysfunction, nausea, or akathisia. Deplin may not be right for you if you have a hypersensitivity to folic acid.
Please consult your physician regarding your symptoms.
Posted by mogger on August 5, 2011, at 20:13:09
In reply to Re: Is anyone using Deplin still? » SusanWhelan, posted by Phillipa on July 13, 2011, at 21:41:56
Hi there,
I went to my doctor and got an MTHFR test done to see if Deplin might help me but the results leave me completely lost.
I test "positive for one copy of the A1298C Mutation. I am "heterozygous for the A1298C mutation and negative (normal) for the C677T mutation in the MTHFR gene".
Does anyone know how to interpret these results? :) Many thanks,
Joseph
Posted by SLS on August 6, 2011, at 4:59:38
In reply to Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 5, 2011, at 20:13:09
> Hi there,
>
> I went to my doctor and got an MTHFR test done to see if Deplin might help me but the results leave me completely lost.
>
> I test "positive for one copy of the A1298C Mutation. I am "heterozygous for the A1298C mutation and negative (normal) for the C677T mutation in the MTHFR gene".
>
> Does anyone know how to interpret these results? :) Many thanks,
>
> Joseph
Apparently, the gene is autosomal dominant. That's like the brown eye allele predominating over the blue eye allele in humans. That you are heterozygous for this gene indicates that you have one normal allele and one mutated allele.You've got one mutated gene and one normal gene. The mutatated gene is stronger than the normal one, and will yield the mutated phenotype. In this case, the mutation will show up in both the homozygous A/A condition and the A/B heterozygous conditions, but not B/B homozygous.
Does this help? If not, feel free to reply to this post.
- Scott
Posted by mogger on August 6, 2011, at 9:04:07
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by SLS on August 6, 2011, at 4:59:38
Wow Scott thanks so much for replying and explaining it for me. I am blonde however and have no idea what you mean so would you mind explaining it in more simple terms? I am thinking about trying deplin but want to see if i metabolize folic acid properly or whether i should try it. I heard that this was the test to find out but i can't figure out my results. Many thanks,
Joseph :)
P.s.- how are you doing by the way?
Posted by Phillipa on August 6, 2011, at 18:28:39
In reply to Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 5, 2011, at 20:13:09
I wish I did might google Susan Whelan as works for Deplin? What does the doc say? Phillipa
Posted by SLS on August 6, 2011, at 21:05:58
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 6, 2011, at 9:04:07
> Wow Scott thanks so much for replying and explaining it for me. I am blonde however and have no idea what you mean so would you mind explaining it in more simple terms?
:-)
> I am thinking about trying deplin but want to see if i metabolize folic acid properly or whether i should try it. I heard that this was the test to find out but i can't figure out my results. Many thanks,
The gene being tested codes for an enzyme that manufactures folate from folic acid. The enzyme is ethylene-tetra-hydro-folate-reductase (MTHFR). With the mutation, less folic acid is converted to the biologically active form, L-methylfolate. If you have the mutation, the amount of MTHFR becomes too low and results in low L-methylfolate levels.
I have never heard of this test before. I imagine that a positive result for the mutated gene indicates a need for supplementation with Deplin.
> P.s.- how are you doing by the way?
Thanks for asking.
Today was a particularly good day. It represented a step forward towards attaining remission. I haven't felt this well in 24 years. However, progress is slow, and patience is a precious commodity. I added Nardil a year ago. To me, it feels like it will take at least another year to respond fully.
- Scott
Posted by mogger on August 6, 2011, at 21:57:01
In reply to Re: Can anyone interpret MTHFR Gene Test Results? » mogger, posted by SLS on August 6, 2011, at 21:05:58
Scott,
What great news to hear about your improvement. Patience is so key I agree as I started my recovery back in 1999 when lamictal was added and then slowly my doctor and I have been tweaking things to take me to the next level. I am still recovering and my doctor always says to me "you are making up for lost time" which is so true. I am genuinely thrilled to hear of your progress. Many thanks for you interpreting the test results for a dumb blonde. All the best,
Joseph
Posted by larryhoover on August 7, 2011, at 10:50:16
In reply to Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 5, 2011, at 20:13:09
> Hi there,
>
> I went to my doctor and got an MTHFR test done to see if Deplin might help me but the results leave me completely lost.
>
> I test "positive for one copy of the A1298C Mutation. I am "heterozygous for the A1298C mutation and negative (normal) for the C677T mutation in the MTHFR gene".
>
> Does anyone know how to interpret these results? :) Many thanks,
> JosephAccording to this website, your test results indicate that your MTHFR enzyme activity ought to be normal. The test should be interpreted with the results of a test for blood homocysteine levels. If you do not have hyperhomocysteinemia, then all is well (from a blood chemistry standpoint). You might still benefit from Deplin, but I think it is less likely than in someone who has both the mutations identified above. (The reason that you might still benefit is that there are probably other mutations in this gene that are not detected by this test.)
http://www.kimballgenetics.com/tests-mthfr.html
Lar
Posted by larryhoover on August 7, 2011, at 11:40:06
In reply to Re: Can anyone interpret MTHFR Gene Test Results? » mogger, posted by SLS on August 6, 2011, at 21:05:58
> I haven't felt this well in 24 years.
>
> - ScottScott, that is a very dramatic and powerful statement. I pray that you only move forward from here, my friend.
Lar
Posted by mogger on August 7, 2011, at 20:03:00
In reply to Re: Can anyone interpret MTHFR Gene Test Results? » mogger, posted by larryhoover on August 7, 2011, at 10:50:16
Lar,
I appreciate your interpretation! Many thanks,
Joseph
Posted by SusanWhelan on August 12, 2011, at 18:36:53
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 7, 2011, at 20:03:00
Hi, I think that you received the information that you need. I encourage you to discuss your results with your doctor.
I wanted to let everyone know that there may be someone else commenting on behalf of Deplin. He is very knowledgeable about the product (more so than myself). Hopefully he will be able to answer your questions.
Posted by mogger on August 12, 2011, at 23:29:41
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by SusanWhelan on August 12, 2011, at 18:36:53
Thanks Susan although I have three different interpretations of the results. If you wouldn't mind pointing the Deplin employee over to this post that would be awesome as perhaps he can confirm whether it would be effective or not. My General Practitioner actually doesn't really know how to interpret the results as he has never ran the blood test before until me. Many thanks,
Joseph
Posted by Phillipa on August 13, 2011, at 0:21:14
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 12, 2011, at 23:29:41
Joseph isn't Susan helpful and what a chance to really learn about Deplin. Phillipa Jan
Posted by mogger on August 13, 2011, at 0:24:03
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 12, 2011, at 23:29:41
Susan is so helpful Jan she always replies promptly which is great. I am a big fan of Deplin and would love to know whether it would work for me. My GP did say it takes 4-6 weeks to see improvement and 15mg is the effective dose.
Joseph
Posted by Phillipa on August 13, 2011, at 0:28:12
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 13, 2011, at 0:24:03
Joseph yes she is they also have webinars. I didn't continue with the Deplin. Will see what this rep has to say as still have script for it. And yes 15mg now they are saying. Hope it works well for you. Jan
Posted by mogger on August 13, 2011, at 0:30:35
In reply to Re: Can anyone interpret MTHFR Gene Test Results? » mogger, posted by Phillipa on August 13, 2011, at 0:28:12
Thanks Jan I am slowly going down on my zoloft and then will hopefully try Deplin once I get down to my targeted dose of zoloft. All the best to you,
Joseph
Posted by Zatar on August 14, 2011, at 22:56:58
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 13, 2011, at 0:24:03
>My GP did say it takes 4-6 weeks to see improvement and 15mg is the effective dose.
I tested homozygous for MTHFR C677T and heterozygous for A1298T but my homocysteine levels test consistently normal though my LDL is slightly elevated possibly secondary to fibromyalgia and possibly elevated inflammatory factors. I have started taking multivitamins from Thorne which contains 400mcg of 5-L-MTHFR without any perceivable benefit. My pdoc gave me some samples of Deplin but I'm wondering if I should wait to take it along with whatever new medication he might prescribe at my upcoming appointment because I've never heard of Deplin as mono therapy. I don't currently take anything for anxiety and depression because I cannot tolerate most AD due to side effects and my new pdoc is finally putting his thinking cap on to see what new ideas he can up with. The dose of 5-L-MTHFR in the multivit might be too low.
I don't think you can make generalizations about genetic polymorphisms because I never had difficulty getting pregnant taking prenatal vitamins which contained regular folic acid. There must be redundancies in folate metabolism in the human body.
What factors would suggest success using Deplin?
Zatar
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