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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Duva on July 27, 2011, at 16:56:13
Hello, I saw a post here from several years ago from a woman who had done a Parnate trial but had to go off of it within the first few days because of hypertension. This is pretty much what happened to me: I had no history of hypertension, was put on Parnate and taken off after three weeks because of severe hypertension (170/140 was the highest reading). Problem: Hypertension did not resolve after Parnate was stopped. That was a year ago. Anyone else have this experience? Any advice?
Posted by emmanuel98 on July 27, 2011, at 19:13:21
In reply to Parnate and unresolved hypertension, posted by Duva on July 27, 2011, at 16:56:13
It seems unlikely that three weeks on parnate with a year off have caused your hypertension, especially because parnate usually causes hypotension, not hypertension. Maybe it's just a coincidence that your hypertension manifested itself at the time you were taking parnate.
Posted by Duva on July 27, 2011, at 20:15:11
In reply to Re: Parnate and unresolved hypertension, posted by emmanuel98 on July 27, 2011, at 19:13:21
> It seems unlikely that three weeks on parnate with a year off have caused your hypertension, especially because parnate usually causes hypotension, not hypertension. Maybe it's just a coincidence that your hypertension manifested itself at the time you were taking parnate.
> I know it might seem strange because the med has been out of my system, but I went from no hypertension prior to parnate to severe (stage 2) hypetension 3 wks. later. Parnate is actually linked with hypertension - there is a lot on the web about people having hypertensive crises, some fatal, while on Parnate. It is why the drug is not used very often - because of this danger. Not sure if this is the proper posting etiquette, but here is a copy & paste of the post I was referring to. Same thing happened to me: "I've read several things here and elsewhere on Dr Bob's site about Parnate sometimes causing spontaneous hypertension. In January I started Parnate. The day prior my BP was 127/78. After three days on Parnate, my BP was 199/110. I was adhering to the strictest diet so I know it was not a tyramine reaction. I stopped Parnate. Here's the problem. My BP did not return to normal. The following week, my internist put me on Dyazide and then added Norvasc. It has dropped to 160/90. Did the BP of other people who experienced spontaneous hypertension from Parnate remain elevated? Is there a chance my BP could still return to normal or am I now stuck taking this nauseating med for life?"
Posted by Phillipa on July 28, 2011, at 0:23:07
In reply to Re: Parnate and unresolved hypertension, posted by Duva on July 27, 2011, at 20:15:11
So you have a diagnosis of hypertension? Phillipa
Posted by Duva on July 28, 2011, at 5:23:42
In reply to Re: Parnate and unresolved hypertension » Duva, posted by Phillipa on July 28, 2011, at 0:23:07
yes -- Stage 2 hypertension that did not respond to first two blood pressure meds (or did not respond enough). I have been in the ER with BP so high they said I could have a stroke. But then they say it is "aging" or "anxiety" (one EMT said "If you would stop making yourself hysterical..."). But I was only on the Parnate for three weeks and had no hypertension prior to Parnate (if I did, as my dr. said, he wouldn't have prescribed it). Also I've had anxiety all my life, but never BP's like this. Don't want to have to be on meds for this the rest of my life - can't afford copays, side effects. some cause depression, which is why I was on Parnate. I'm 46 and in good shape - exercise, eat vegetarian, low salt, not overweight, and don't smoke/drink.
Posted by desolationrower on July 30, 2011, at 21:31:48
In reply to Re: Parnate and unresolved hypertension, posted by Duva on July 28, 2011, at 5:23:42
I would also guess it is a coincidence. you are probably more aware of bp now?
They way parnate causes (acute) hypertensions is by attachign to all the MAO, tyramine from the diet can enter the body and it causes release of catecholamines (similar to injecting tyramine). mao regenerates so this wouldn't be the way, even if parnate was doing something.
-d/r
Posted by Duva on July 30, 2011, at 21:43:24
In reply to Re: Parnate and unresolved hypertension, posted by desolationrower on July 30, 2011, at 21:31:48
my dr. said he checked for hypertension history just prior to parnate trial, as they were contraindicated. I was on it for all of three weeks. Now, STAGE II hypertension. Never mind, guess I am just a crazy *ss borderline with crazy ideas. At least it's a way out. I hope it comes quick
Posted by brionk on August 1, 2011, at 23:23:56
In reply to Re: Parnate and unresolved hypertension, posted by Duva on July 30, 2011, at 21:43:24
Posted by brionk on August 2, 2011, at 10:05:31
In reply to Re: Parnate and unresolved hypertension (nm), posted by brionk on August 1, 2011, at 23:23:56
test post...
Posted by Aussie2 on February 25, 2012, at 3:31:52
In reply to Re: Parnate and unresolved hypertension, posted by Duva on July 30, 2011, at 21:43:24
Of course you would be aware of all the listed foods which possibly result in hypertensive attacks while on Parnate. The list packaged with the medication is incomplete I believe. Lots of info here: < http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20020709/msgs/112604.html >
But why your BP is still up - ??. If you are regularly eating one of the offending foods it may be possible that the remaining traces of Parnate could be causing a continuing interaction(?). A reduction in the diameter of the cardio vascular system members is the reaction.(The regular small dose aspirin method of guarding the BP may be useful. Always taken with food.)
I found chocolate in large quantity IS a possible danger with Parnate. It is not commonly known or acknowledged. It put me in the cardiac ward. Age and anxiety/stress also add to those factors. It is not recommended for over 65's. Me.
This is the end of the thread.
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