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Dr. Bob is Robert Hsiung, MD,
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Posted by Phillipa on June 26, 2011, at 22:01:01
In reply to Re: Is anyone using Deplin still?, posted by mogger on June 26, 2011, at 19:48:24
Mogger so if I read it correctly as read fast it still works if you don't have the genetic factor for absorbing the folate or did I read it wrong. Copy and will paste and sent to me to read througly later. Thanks if in Fla all my grown kids also are. Stuart, Palm City, Palm Bay. Phillipa
Posted by mogger on June 26, 2011, at 22:25:53
In reply to Re: Is anyone using Deplin still? » mogger, posted by Phillipa on June 26, 2011, at 22:01:01
Yes Phillipa he says it can still work if you do or don't have the gene! Hope you are having fun in Florida! Joseph
Posted by Phillipa on June 27, 2011, at 0:18:31
In reply to Re: Is anyone using Deplin still?, posted by mogger on June 26, 2011, at 22:25:53
Mogger my grown kids are in Florida me in NC ick!!!! I do think I still have some Deplin and do have a script but for the 7.5mg pills wonder if they would do anything? Thanks again. You living down in Fla yourself? Phillipa
Posted by mogger on June 27, 2011, at 8:48:15
In reply to Re: Is anyone using Deplin still? » mogger, posted by Phillipa on June 27, 2011, at 0:18:31
Phillipa take two 7.5mg tablets a day and try it out for two weeks and see what you think. Can you get another script from your doc if you see improvements? I am in los Angeles! I have always wanted to go to NC and love Florida! :)
Posted by Phillipa on June 27, 2011, at 20:28:07
In reply to Re: Is anyone using Deplin still? » Phillipa, posted by mogger on June 27, 2011, at 8:48:15
Let me check my stock. Los Angeles? So you like Florida or North Carolina better? Florida maybe but NC no!!!! Displaced Fairfield county Ct Yankee here. Phillipa
Posted by mogger on June 27, 2011, at 20:37:43
In reply to Re: Is anyone using Deplin still? » mogger, posted by Phillipa on June 27, 2011, at 20:28:07
:)!
Posted by Phillipa on June 27, 2011, at 22:05:52
In reply to Re: Is anyone using Deplin still?, posted by mogger on June 27, 2011, at 20:37:43
Mogger do you take at night or am? I only have about 8 but do have a script. No sides right as doing some changing with meds. Phillipa
Posted by henryo on June 28, 2011, at 2:38:06
In reply to Is anyone using Deplin still?, posted by Laney on June 22, 2011, at 12:08:36
Yes I take it still. I love it. I get the 15's and break them cause they are the same cost as the 7.5's. That way I get twice as much for the same price. My insurance has it listed as "medical food" so it isn't covered. What a scam. I felt the effects in under 48 hours. I have many posts on this board about my experiences with Deplin. Use the search at he bottom of the page. I doesn't cause anemia but it can mask B12 deficiency so I just inject myself with B12 once a month to be sure. I find Deplin activating and I tell everybody to give it a try. I haven't seen very many other people on here who think it is as wonderful as I do. There is a lot of info on it all over the web. Try it.
Posted by Phillipa on June 28, 2011, at 19:09:25
In reply to Re: Is anyone using Deplin still?, posted by henryo on June 28, 2011, at 2:38:06
Henyro that doesn't seem right as if you need a RX for it how isn't it covered? Do you have that missing gene? Phillipa
Posted by mogger on June 28, 2011, at 19:22:27
In reply to Re: Is anyone using Deplin still? » henryo, posted by Phillipa on June 28, 2011, at 19:09:25
Henryo has the Deplin helped your anxiety at all if you had any to begin with or just depression? That is so annoying that it costs so much, i priced it at 60 for my insurance if i ask my doc to try it.
Posted by SusanWhelan on July 13, 2011, at 17:33:35
In reply to Re: Is anyone using Deplin still?, posted by mogger on June 28, 2011, at 19:22:27
Hi, I work with Deplin. Thanks for the testimonial, Henryo. I have previously answered questions for Phillipa, but maybe I can give all of you some additional information?
As you probably know, Deplin is l-methyfolate, the active form of folate and is prescribed to augment other treatment of depression. Deplin works to manage the monamines associated with mood. It is considered a medical food, not a drug.
A recent study of the 15 mg dose as adjunctive therapy showed a superior response- with 2x the patients responding- and an 84% reduction in depressive symptoms compared to antidepressant + placebo.
Some patients may need to take 4-6 weeks to see complete response.
You do not need to have MTHFR to see results from Deplin but it is estimated that 70% of depressed patients is affected by MTHFR polymorphism (compared to 50% of the general population).
You might find these articles helpful:
http://www.psychologytoday.com/blog/inner-source/201106/folic-acid-the-equalizing-b-vitaminhttp://dailywd.womansday.com/health/daily-dose/2011/antidepressants/
http://chipur.com/2011/05/19/update-l-methylfolate-and-depression-more-good-news/
For those of you that do not purchase through insurance, there is a savings program through Brand Direct Health, available on the Deplin website.
I hope this information helps.
Posted by mogger on July 13, 2011, at 18:17:46
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 13, 2011, at 17:33:35
Thanks so much for the reply. I just was at my General Practitioner yesterday who was supportive of Deplin and gave me plenty of samples to try. He has had great success with it but as you say he says it takes a while to work. He was nice enough to listen to me and was happy to order the MTHFR test which I am awaiting the results. Many thanks again,
Joseph
Posted by Phillipa on July 13, 2011, at 21:41:56
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 13, 2011, at 17:33:35
Susan thanks for the links. When another webcam comes up let us know? Phillipa
Posted by SusanWhelan on July 14, 2011, at 7:13:31
In reply to Re: Is anyone using Deplin still? » SusanWhelan, posted by Phillipa on July 13, 2011, at 21:41:56
Sure, I'll post when we host another webinar.
Posted by Phillipa on July 14, 2011, at 20:34:41
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 14, 2011, at 7:13:31
Susan I'm sure others would appreciate this. Since we started talking Deplin again have heard from other posters that their docs are having good success. Any comments or statistics? Phillipa
Posted by SusanWhelan on July 18, 2011, at 18:22:03
In reply to Re: Is anyone using Deplin still? » SusanWhelan, posted by Phillipa on July 14, 2011, at 20:34:41
I'm not sure what you mean. Do you want statistics from the study?
The clinical trials can be found here:
http://www.deplin.com/HealthcareProfessionals,TrialsThe most recent study is the first one on that web page, which is often referred to as the "Fava study." In that study, 32.2% of the participants responded to Deplin 15mg + antidepressant in 30 days. Of the patients that responded, they showed an 84% greater reduction in depressive symptoms.
Here is another article that may help:
http://www.foxnews.com/health/2011/06/02/vitamin-that-fights-depression/
Posted by Phillipa on July 18, 2011, at 21:54:33
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 18, 2011, at 18:22:03
Thanks Susan you are an asset to this medication board and speak for Others also when I say I do appreciate the links thanks again so much!!! Phillipa
Posted by sac on July 20, 2011, at 6:16:21
In reply to Re: Is anyone using Deplin still?, posted by SusanWhelan on July 18, 2011, at 18:22:03
I was recently prescribed Deplin 15 mgs. to augment my AD's. I started with 7.5 mgs and never made it up to 15 mgs because I could not sleep at night. I was on this dose for a week when I developed numbness alternating with burning in my feet. I have never experienced this before. I discontinued the Deplin two weeks ago and the burning/numbness has improved but is not entirely gone. I am worried about this, is Deplin associated with nerve damage?
Posted by SusanWhelan on July 20, 2011, at 10:41:36
In reply to Re: Is anyone using Deplin still? My strange exp., posted by sac on July 20, 2011, at 6:16:21
Any new symptoms or side effects of any medication should be discussed with your doctor. You can find information on what to expect with Deplin here. http://www.deplin.com/DeplinFacts,WhatToExpect
Deplin has not been associated with weight gain, sexual dysfunction, nausea, or akathisia. Deplin may not be right for you if you have a hypersensitivity to folic acid.
Please consult your physician regarding your symptoms.
Posted by mogger on August 5, 2011, at 20:13:09
In reply to Re: Is anyone using Deplin still? » SusanWhelan, posted by Phillipa on July 13, 2011, at 21:41:56
Hi there,
I went to my doctor and got an MTHFR test done to see if Deplin might help me but the results leave me completely lost.
I test "positive for one copy of the A1298C Mutation. I am "heterozygous for the A1298C mutation and negative (normal) for the C677T mutation in the MTHFR gene".
Does anyone know how to interpret these results? :) Many thanks,
Joseph
Posted by SLS on August 6, 2011, at 4:59:38
In reply to Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 5, 2011, at 20:13:09
> Hi there,
>
> I went to my doctor and got an MTHFR test done to see if Deplin might help me but the results leave me completely lost.
>
> I test "positive for one copy of the A1298C Mutation. I am "heterozygous for the A1298C mutation and negative (normal) for the C677T mutation in the MTHFR gene".
>
> Does anyone know how to interpret these results? :) Many thanks,
>
> Joseph
Apparently, the gene is autosomal dominant. That's like the brown eye allele predominating over the blue eye allele in humans. That you are heterozygous for this gene indicates that you have one normal allele and one mutated allele.You've got one mutated gene and one normal gene. The mutatated gene is stronger than the normal one, and will yield the mutated phenotype. In this case, the mutation will show up in both the homozygous A/A condition and the A/B heterozygous conditions, but not B/B homozygous.
Does this help? If not, feel free to reply to this post.
- Scott
Posted by mogger on August 6, 2011, at 9:04:07
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by SLS on August 6, 2011, at 4:59:38
Wow Scott thanks so much for replying and explaining it for me. I am blonde however and have no idea what you mean so would you mind explaining it in more simple terms? I am thinking about trying deplin but want to see if i metabolize folic acid properly or whether i should try it. I heard that this was the test to find out but i can't figure out my results. Many thanks,
Joseph :)
P.s.- how are you doing by the way?
Posted by Phillipa on August 6, 2011, at 18:28:39
In reply to Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 5, 2011, at 20:13:09
I wish I did might google Susan Whelan as works for Deplin? What does the doc say? Phillipa
Posted by SLS on August 6, 2011, at 21:05:58
In reply to Re: Can anyone interpret MTHFR Gene Test Results?, posted by mogger on August 6, 2011, at 9:04:07
> Wow Scott thanks so much for replying and explaining it for me. I am blonde however and have no idea what you mean so would you mind explaining it in more simple terms?
:-)
> I am thinking about trying deplin but want to see if i metabolize folic acid properly or whether i should try it. I heard that this was the test to find out but i can't figure out my results. Many thanks,
The gene being tested codes for an enzyme that manufactures folate from folic acid. The enzyme is ethylene-tetra-hydro-folate-reductase (MTHFR). With the mutation, less folic acid is converted to the biologically active form, L-methylfolate. If you have the mutation, the amount of MTHFR becomes too low and results in low L-methylfolate levels.
I have never heard of this test before. I imagine that a positive result for the mutated gene indicates a need for supplementation with Deplin.
> P.s.- how are you doing by the way?
Thanks for asking.
Today was a particularly good day. It represented a step forward towards attaining remission. I haven't felt this well in 24 years. However, progress is slow, and patience is a precious commodity. I added Nardil a year ago. To me, it feels like it will take at least another year to respond fully.
- Scott
Posted by mogger on August 6, 2011, at 21:57:01
In reply to Re: Can anyone interpret MTHFR Gene Test Results? » mogger, posted by SLS on August 6, 2011, at 21:05:58
Scott,
What great news to hear about your improvement. Patience is so key I agree as I started my recovery back in 1999 when lamictal was added and then slowly my doctor and I have been tweaking things to take me to the next level. I am still recovering and my doctor always says to me "you are making up for lost time" which is so true. I am genuinely thrilled to hear of your progress. Many thanks for you interpreting the test results for a dumb blonde. All the best,
Joseph
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